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Batsis M, Kochilas L, Chin AJ, et al. Association of Digoxin With Preserved Echocardiographic Indices in the Interstage Period: A Possible Mechanism to Explain Improved Survival?. J Am Heart Assoc. 2021;10(23):e021443doi: 10.1161/JAHA.121.021443.
Batsis, M., Kochilas, L., Chin, A. J., Kelleman, M., Ferguson, E., & Oster, M. E. (2021). Association of Digoxin With Preserved Echocardiographic Indices in the Interstage Period: A Possible Mechanism to Explain Improved Survival?. Journal of the American Heart Association, 10(23), e021443. https://doi.org/10.1161/JAHA.121.021443
Batsis, Maria, et al. "Association of Digoxin With Preserved Echocardiographic Indices in the Interstage Period: A Possible Mechanism to Explain Improved Survival?." Journal of the American Heart Association vol. 10,23 (2021): e021443. doi: https://doi.org/10.1161/JAHA.121.021443
Batsis M, Kochilas L, Chin AJ, Kelleman M, Ferguson E, Oster ME. Association of Digoxin With Preserved Echocardiographic Indices in the Interstage Period: A Possible Mechanism to Explain Improved Survival?. J Am Heart Assoc. 2021 Dec 07;10(23):e021443. doi: 10.1161/JAHA.121.021443. Epub 2021 Dec 02. PMID: 34854311.
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J Am Heart Assoc. 2021 Dec 07;10(23):e021443. doi: 10.1161/JAHA.121.021443. Epub 2021 Dec 02.

Association of Digoxin With Preserved Echocardiographic Indices in the Interstage Period: A Possible Mechanism to Explain Improved Survival?.

Journal of the American Heart Association

Maria Batsis, Lazaros Kochilas, Alvin J Chin, Michael Kelleman, Eric Ferguson, Matthew E Oster

Affiliations

  1. Sibley Heart Center Cardiology Children's Healthcare of Atlanta Atlanta GA.
  2. Department of Pediatrics Emory University School of Medicine Atlanta GA.
  3. Department of Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia PA.

PMID: 34854311 DOI: 10.1161/JAHA.121.021443

Abstract

Background For patients with hypoplastic left heart syndrome, digoxin has been associated with reduced interstage mortality after the Norwood operation, but the mechanism of this benefit remains unclear. Preservation of right ventricular (RV) echocardiographic indices has been associated with better outcomes in hypoplastic left heart syndrome. Therefore, we sought to determine whether digoxin use is associated with preservation of the RV indices in the interstage period. Methods and Results We conducted a retrospective cohort study of prospectively collected data using the public use data set from the Pediatric Heart Network Single Ventricle Reconstruction trial, conducted in 15 North American centers between 2005 and 2008. We included all patients who survived the interstage period and had echocardiographic data post-Norwood and pre-Glenn operations. We used multivariable linear regression to compare changes in RV parameters, adjusting for relevant covariates. Of 289 patients, 94 received digoxin at discharge post-Norwood. There were no significant differences in baseline clinical characteristics or post-Norwood echocardiographic RV indices (RV end-diastolic volume indexed, RV end-systolic volume indexed, ejection fraction) in the digoxin versus no-digoxin groups. At the end of the interstage period and after adjustment for relevant covariates, patients on digoxin had better preserved RV indices compared with those not on digoxin for the ΔRV end-diastolic volume (11 versus 15 mL,

Keywords: congenital heart disease; digoxin; hypoplastic left heart syndrome; interstage; right ventricular echocardiography; right ventricular volume; single ventricle

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