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Bruijn LE, van Stroe Gómez CG, Curci JA, et al. A histopathological classification scheme for abdominal aortic aneurysm disease. JVS Vasc Sci. 2021;2:260-273doi: 10.1016/j.jvssci.2021.09.001.
Bruijn, L. E., van Stroe Gómez, C. G., Curci, J. A., Golledge, J., Hamming, J. F., Jones, G. T., Lee, R., Matic, L., van Rhijn, C., Vriens, P. W., Wågsäter, D., Xu, B., Yamanouchi, D., & Lindeman, J. H. (2021). A histopathological classification scheme for abdominal aortic aneurysm disease. JVS-vascular science, 2260-273. https://doi.org/10.1016/j.jvssci.2021.09.001
Bruijn, Laura E, et al. "A histopathological classification scheme for abdominal aortic aneurysm disease." JVS-vascular science vol. 2 (2021): 260-273. doi: https://doi.org/10.1016/j.jvssci.2021.09.001
Bruijn LE, van Stroe Gómez CG, Curci JA, Golledge J, Hamming JF, Jones GT, Lee R, Matic L, van Rhijn C, Vriens PW, Wågsäter D, Xu B, Yamanouchi D, Lindeman JH. A histopathological classification scheme for abdominal aortic aneurysm disease. JVS Vasc Sci. 2021 Oct 07;2:260-273. doi: 10.1016/j.jvssci.2021.09.001. eCollection 2021. PMID: 34825232; PMCID: PMC8605212.
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JVS Vasc Sci. 2021 Oct 07;2:260-273. doi: 10.1016/j.jvssci.2021.09.001. eCollection 2021.

A histopathological classification scheme for abdominal aortic aneurysm disease.

JVS-vascular science

Laura E Bruijn, Charid G van Stroe Gómez, John A Curci, Jonathan Golledge, Jaap F Hamming, Greg T Jones, Regent Lee, Ljubica Matic, Connie van Rhijn, Patrick W Vriens, Dick Wågsäter, Baohui Xu, Dai Yamanouchi, Jan H Lindeman

Affiliations

  1. Division of Vascular Surgery, Department of Surgery, Leiden University Medical Center (LUMC), Leiden, the Netherlands.
  2. Section of Surgical Sciences, Department of Vascular Surgery, Vanderbilt University Medical Center, Nashville, Tenn.
  3. Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.
  4. Department of Vascular and Endovascular Surgery, The Townsville University Hospital, Townsville, Queensland, Australia.
  5. Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia.
  6. Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
  7. Nuffield Dept. of Surgical Sciences, University of Oxford, Headington, United Kingdom.
  8. Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
  9. Department of Surgery, Elisabeth-TweeSteden Ziekenhuis, Tilburg, the Netherlands.
  10. Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
  11. Department of Surgery, Division of Vascular Surgery, Stanford University School of Medicine, Stanford, Calif.
  12. Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, Wisc.

PMID: 34825232 PMCID: PMC8605212 DOI: 10.1016/j.jvssci.2021.09.001

Abstract

OBJECTIVE: Two consensus histopathological classifications for thoracic aortic aneurysms (TAAs) and inflammatory aortic diseases have been issued to facilitate clinical decision-making and inter-study comparison. However, these consensus classifications do not specifically encompass abdominal aortic aneurysms (AAAs). Given its high prevalence and the existing profound pathophysiologic knowledge gaps, extension of the consensus classification scheme to AAAs would be highly instrumental. The aim of this study was to test the applicability of, and if necessary to adapt, the issued consensus classification schemes for AAAs.

METHODS: Seventy-two AAA anterolateral wall samples were collected during elective and emergency open aneurysm repair performed between 2002 and 2013. Histologic analysis (hematoxylin and eosin and Movat Pentachrome) and (semi-quantitative and qualitative) grading were performed in order to map the histological aspects of AAA. Immunohistochemistry was performed for visualization of aspects of the adaptive and innate immune system, and for a more detailed analysis of atherosclerotic lesions in AAA.

RESULTS: Because the existing consensus classification schemes do not adequately capture the aspects of AAA disease, an AAA-specific 11-point histopathological consensus classification was devised. Systematic application of this classification indicated several universal features for AAA (eg, [almost] complete elastolysis), but considerable variation for other aspects (eg, inflammation and atherosclerotic lesions).

CONCLUSIONS: This first multiparameter histopathological AAA consensus classification illustrates the sharp histological contrasts between thoracic and abdominal aneurysms. The value of the proposed scoring system for AAA disease is illustrated by its discriminatory capacity to identify samples from patients with a nonclassical (genetic) variant of AAA disease.

© 2021 by the Society for Vascular Surgery. Published by Elsevier Inc.

Keywords: Abdominal aortic aneurysm; Classification; Histology; Thoracic aortic aneurysm; Vascular remodeling

References

  1. Cardiovasc Res. 2011 Apr 1;90(1):18-27 - PubMed
  2. Int J Cardiol. 2016 Dec 1;224:328-334 - PubMed
  3. J Am Heart Assoc. 2015 Mar 26;4(4): - PubMed
  4. J Vasc Surg. 2018 Jun;67(6):1891-1900.e4 - PubMed
  5. Oncotarget. 2015 May 30;6(15):12984-96 - PubMed
  6. J Clin Invest. 1998 Dec 1;102(11):1900-10 - PubMed
  7. N Engl J Med. 2003 Dec 11;349(24):2316-25 - PubMed
  8. Cardiovasc Res. 2011 Jul 15;91(2):358-67 - PubMed
  9. Atherosclerosis. 2010 May;210(1):100-6 - PubMed
  10. Cardiovasc Pathol. 2016 May-Jun;25(3):247-257 - PubMed
  11. Nat Rev Cardiol. 2016 Feb;13(2):79-98 - PubMed
  12. J Vasc Surg. 2001 Aug;34(2):291-9 - PubMed
  13. Circ Res. 2019 Feb 15;124(4):588-606 - PubMed
  14. Front Surg. 2016 Jan 25;3:1 - PubMed
  15. Circ Res. 2014 May 23;114(11):1772-87 - PubMed
  16. Clin Sci (Lond). 2008 Jun;114(11):687-97 - PubMed
  17. Cardiovasc Pathol. 2015 Sep-Oct;24(5):267-78 - PubMed
  18. J Am Heart Assoc. 2017 Nov 30;6(12): - PubMed
  19. Crit Care. 2016 Oct 21;20(1):319 - PubMed
  20. Springerplus. 2015 May 16;4:231 - PubMed
  21. Exp Mol Med. 2019 Dec 19;51(12):1-15 - PubMed
  22. Cardiovasc Pathol. 2017 Mar - Apr;27:71-75 - PubMed
  23. BJS Open. 2021 Jan 8;5(1): - PubMed
  24. Cardiovasc Res. 2021 Apr 23;117(5):1402-1416 - PubMed
  25. Cytokine. 2018 Aug;108:96-104 - PubMed
  26. Expert Rev Cardiovasc Ther. 2015;13(9):975-87 - PubMed
  27. Eur J Vasc Endovasc Surg. 2020 Mar;59(3):494 - PubMed
  28. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1075-7 - PubMed
  29. Oncoimmunology. 2017 Dec 18;7(2):e1378844 - PubMed
  30. Arterioscler Thromb Vasc Biol. 2006 May;26(5):987-94 - PubMed
  31. Circulation. 2014 Jun 17;129(24):2557-66 - PubMed
  32. J Thorac Cardiovasc Surg. 2008 Nov;136(5):1123-30 - PubMed
  33. Nat Rev Cardiol. 2019 Jul;16(7):389-406 - PubMed

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