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Front Immunol. 2021 Nov 05;12:716314. doi: 10.3389/fimmu.2021.716314. eCollection 2021.

Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest.

Frontiers in immunology

Caroline Vilas Boas de Melo, Felipe Guimarães Torres, Micely D'El-Rei Hermida, Jonathan L M Fontes, Bianca Ramos Mesquita, Reginaldo Brito, Pablo Ivan P Ramos, Gabriel R Fernandes, Luiz Antônio Rodrigues Freitas, Ricardo Khouri, Carlos Henrique Nery Costa, Washington L C Dos-Santos

Affiliations

  1. Laboratório de Patologia Estrutural e Molecular (LAPEM), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  2. Laboratório de Enfermidades Infecciosas Transmitidas por Vetores (LEITV), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  3. Centro de Integração de Dados e Conhecimentos para Saúde (CIDACS), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  4. Informática de Biossistemas, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazil.
  5. Departamento de Medicina Comunitária, Instituto de Doenças Tropicais Natan Portella, Universidade Federal do Piauí, Teresina, Brazil.

PMID: 34804009 PMCID: PMC8602831 DOI: 10.3389/fimmu.2021.716314

Abstract

Structural changes in the spleen have been reported in several infectious diseases. In visceral leishmaniasis (VL), a severe parasitic disease caused by

Copyright © 2021 de Melo, Guimarães Torres, Hermida, Fontes, Mesquita, Brito, Ramos, Fernandes, Freitas, Khouri, Costa and dos-Santos.

Keywords: hamster; spleen disorganization; spleen pathology; transcriptomic (RNA-Seq); visceral leishmanaisis; white pulp remodeling

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Bioinformatics. 2015 Jan 15;31(2):166-9 - PubMed
  2. BMC Infect Dis. 2014 Sep 09;14:491 - PubMed
  3. J Immunol. 1997 Apr 15;158(8):3813-21 - PubMed
  4. Br J Exp Pathol. 1983 Oct;64(5):505-14 - PubMed
  5. Leukemia. 2005 Aug;19(8):1404-10 - PubMed
  6. Front Immunol. 2020 Apr 15;11:653 - PubMed
  7. Am J Pathol. 2011 Jul;179(1):23-9 - PubMed
  8. PLoS One. 2014 Feb 03;9(2):e87742 - PubMed
  9. Toxicol Pathol. 2006;34(5):455-65 - PubMed
  10. Infect Immun. 2005 Apr;73(4):1986-94 - PubMed
  11. Stem Cells Dev. 2008 Jun;17(3):495-507 - PubMed
  12. Vet Parasitol. 2012 Mar 23;184(2-4):147-53 - PubMed
  13. Tuberculosis (Edinb). 2013 May;93(3):343-56 - PubMed
  14. Nat Protoc. 2009;4(8):1184-91 - PubMed
  15. PLoS One. 2016 May 31;11(5):e0156733 - PubMed
  16. J Gastroenterol Hepatol. 2018 Apr;33(4):887-893 - PubMed
  17. PLoS One. 2017 Jan 19;12(1):e0169496 - PubMed
  18. PLoS One. 2015 Apr 13;10(4):e0123009 - PubMed
  19. Parasite Immunol. 2012 Oct;34(10):464-72 - PubMed
  20. Cell. 2020 Oct 1;183(1):143-157.e13 - PubMed
  21. Immunol Rev. 2011 Jul;242(1):161-77 - PubMed
  22. J Infect Dis. 2011 Mar 1;203(5):715-25 - PubMed
  23. Indian J Hematol Blood Transfus. 2010 Sep;26(3):78-82 - PubMed
  24. J Transl Med. 2019 Jul 12;17(1):222 - PubMed
  25. J Immunol. 2001 Feb 1;166(3):1912-20 - PubMed
  26. Parasitology. 2019 Sep;146(11):1467-1476 - PubMed
  27. Rev Soc Bras Med Trop. 2010 Jul-Aug;43(4):386-92 - PubMed
  28. IUBMB Life. 2007 Jul;59(7):419-26 - PubMed
  29. Sci Rep. 2019 Sep 10;9(1):12962 - PubMed
  30. Curr Protoc Immunol. 2015 Feb 02;108:19.2.1-19.2.24 - PubMed
  31. Bioinformatics. 2016 Oct 1;32(19):3047-8 - PubMed
  32. Bioinformatics. 2010 Jan 1;26(1):139-40 - PubMed
  33. Immunology. 1977 Nov;33(5):605-10 - PubMed
  34. Front Cell Infect Microbiol. 2018 Nov 13;8:394 - PubMed
  35. J Immunol. 2006 May 1;176(9):5486-93 - PubMed
  36. Wellcome Open Res. 2018 Oct 29;3:135 - PubMed
  37. Nat Rev Immunol. 2005 Aug;5(8):606-16 - PubMed
  38. J Immunol. 2006 May 1;176(9):5519-28 - PubMed
  39. Bioinformatics. 2013 Jan 1;29(1):15-21 - PubMed
  40. Nat Immunol. 2002 Dec;3(12):1185-91 - PubMed
  41. Trends Parasitol. 2004 Nov;20(11):524-30 - PubMed
  42. Parasite Immunol. 2008 Oct;30(10):515-24 - PubMed
  43. Am J Pathol. 2002 Aug;161(2):429-37 - PubMed
  44. Parasite Immunol. 2006 May;28(5):173-83 - PubMed
  45. PLoS One. 2012;7(1):e29103 - PubMed
  46. PLoS Pathog. 2017 Jan 31;13(1):e1006165 - PubMed
  47. Biochim Biophys Acta. 2012 Jun;1822(6):988-95 - PubMed
  48. Histopathology. 2020 Aug;77(2):186-197 - PubMed
  49. PLoS One. 2012;7(10):e47907 - PubMed
  50. J Immunol. 2007 Dec 15;179(12):8446-53 - PubMed

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