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Goldberg A, Garcia-Arroyo F, Sasai F, et al. Mini Review: Reappraisal of Uric Acid in Chronic Kidney Disease. Am J Nephrol. 2021;52(10):837-844doi: 10.1159/000519491.
Goldberg, A., Garcia-Arroyo, F., Sasai, F., Rodriguez-Iturbe, B., Sanchez-Lozada, L. G., Lanaspa, M. A., & Johnson, R. J. (2021). Mini Review: Reappraisal of Uric Acid in Chronic Kidney Disease. American journal of nephrology, 52(10), 837-844. https://doi.org/10.1159/000519491
Goldberg, Avi, et al. "Mini Review: Reappraisal of Uric Acid in Chronic Kidney Disease." American journal of nephrology vol. 52,10 (2021): 837-844. doi: https://doi.org/10.1159/000519491
Goldberg A, Garcia-Arroyo F, Sasai F, Rodriguez-Iturbe B, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Mini Review: Reappraisal of Uric Acid in Chronic Kidney Disease. Am J Nephrol. 2021;52(10):837-844. doi: 10.1159/000519491. Epub 2021 Oct 21. PMID: 34673651; PMCID: PMC8665019.
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Am J Nephrol. 2021;52(10):837-844. doi: 10.1159/000519491. Epub 2021 Oct 21.

Mini Review: Reappraisal of Uric Acid in Chronic Kidney Disease.

American journal of nephrology

Avi Goldberg, Fernando Garcia-Arroyo, Fumihiko Sasai, Bernardo Rodriguez-Iturbe, Laura Gabriela Sanchez-Lozada, Miguel A Lanaspa, Richard J Johnson

Affiliations

  1. Clalit Health Services, Hebrew University of Jerusalem, Jerusalem, Israel.
  2. Department of Cardio-Renal Physiopathology, INC Ignacio Chávez, Mexico City, Mexico.
  3. Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  4. Rocky Mountain VA Medical Center, Aurora, Colorado, USA.

PMID: 34673651 PMCID: PMC8665019 DOI: 10.1159/000519491

Abstract

Hyperuricemia predicts the development of chronic kidney disease (CKD) and metabolic complications, but whether it has a causal role has been controversial. This is especially true given the 2 recently conducted randomized controlled trials that failed to show a benefit of lowering uric acid in type 1 diabetes-associated CKD and subjects with stage 3-4 CKD. While these studies suggest that use of urate-lowering drugs in unselected patients is unlikely to slow the progression of CKD, there are subsets of subjects with CKD where reducing uric acid synthesis may be beneficial. This may be the case in patients with gout, hyperuricemia (especially associated with increased production), and urate crystalluria. Here, we discuss the evidence and propose that future clinical trials targeting these specific subgroups should be performed.

© 2021 S. Karger AG, Basel.

Keywords: Gout; Hyperuricemia; Mendelian randomization; Metabolic syndrome

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