Display options
Share it on

Elife. 2021 Dec 07;10. doi: 10.7554/eLife.73430.

Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology.

eLife

Timothy M Errington, Alexandria Denis, Anne B Allison, Renee Araiza, Pedro Aza-Blanc, Lynette R Bower, Jessica Campos, Heidi Chu, Sarah Denson, Cristine Donham, Kaitlyn Harr, Babette Haven, Elizabeth Iorns, Jennie Kwok, Elysia McDonald, Steven Pelech, Nicole Perfito, Amanda Pike, Darryl Sampey, Michael Settles, David A Scott, Vidhu Sharma, Todd Tolentino, Angela Trinh, Rachel Tsui, Brandon Willis, Joshua Wood, Lisa Young

Affiliations

  1. Center for Open Science, Charlottesville, United States.
  2. Piedmont Virginia Community College, Charlottesville, United States.
  3. University of California, Davis, Davis, United States.
  4. Independent consultant, San Diego, United States.
  5. Applied Biological Materials, Richmond, Canada.
  6. University of Georgia, Athens, United States.
  7. University of Virginia, Charlottesville, United States.
  8. Absorption Systems, Exton, United States.
  9. Science Exchange, Palo Alto, United States.
  10. Drexel University College of Medicine, Philadelphia, United States.
  11. Kinexus Bioinformatics, Vancouver, Canada.
  12. University of British Columbia, Vancouver, United States.
  13. BioFactura, Frederick, United States.
  14. Independent consultant, Naples, United States.
  15. Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States.

PMID: 34874009 PMCID: PMC8651290 DOI: 10.7554/eLife.73430

Abstract

As part of the Reproducibility Project: Cancer Biology, we published Registered Reports that described how we intended to replicate selected experiments from 29 high-impact preclinical cancer biology papers published between 2010 and 2012. Replication experiments were completed and Replication Studies reporting the results were submitted for 18 papers, of which 17 were accepted and published by

© 2021, Errington et al.

Keywords: cancer biology; human; methodology; mouse; null results; open science; replication; reproducibility; transparency

Conflict of interest statement

TE Employed by the nonprofit Center for Open Science that has a mission to increase openness, integrity, and reproducibility of research, AD Was employed by the nonprofit Center for Open Science that

References

  1. PLoS One. 2017 Mar 28;12(3):e0174461 - PubMed
  2. Elife. 2015 Jan 26;4: - PubMed
  3. N Engl J Med. 2005 Feb 24;352(8):786-92 - PubMed
  4. Cell. 2010 Jan 22;140(2):209-21 - PubMed
  5. Hum Mol Genet. 2011 Apr 15;20(R1):R14-20 - PubMed
  6. Nat Methods. 2012 Jul;9(7):671-5 - PubMed
  7. Elife. 2016 Mar 11;5:e10860 - PubMed
  8. Elife. 2014 Dec 10;3: - PubMed
  9. Nature. 2011 Nov 09;479(7374):547-51 - PubMed
  10. Cell. 2010 Apr 2;141(1):69-80 - PubMed
  11. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14903-8 - PubMed
  12. Pigment Cell Melanoma Res. 2010 Apr;23(2):190-200 - PubMed
  13. Nature. 2010 Aug 12;466(7308):869-73 - PubMed
  14. Elife. 2016 Feb 16;5: - PubMed
  15. Trends Cancer. 2019 Mar;5(3):170-182 - PubMed
  16. Cancer Cell. 2013 May 13;23(5):594-602 - PubMed
  17. Eur Neuropsychopharmacol. 2019 Dec;29(12):1312-1320 - PubMed
  18. Nat Commun. 2016 Feb 19;7:10690 - PubMed
  19. PLoS Biol. 2019 Feb 21;17(2):e3000151 - PubMed
  20. Nature. 2010 Dec 9;468(7325):829-33 - PubMed
  21. Front Oncol. 2019 Mar 29;9:194 - PubMed
  22. PLoS Med. 2005 Jan;2(1):e17 - PubMed
  23. Nature. 2010 Dec 9;468(7325):824-8 - PubMed
  24. Elife. 2016 Feb 19;5: - PubMed
  25. Elife. 2015 Feb 25;4: - PubMed
  26. Elife. 2015 Jun 18;4:e06938 - PubMed
  27. PLoS One. 2017 Oct 5;12(10):e0185862 - PubMed
  28. Cancer Cell. 2018 Aug 13;34(2):186-195 - PubMed
  29. Gene. 2018 Jul 30;665:67-73 - PubMed
  30. Elife. 2016 Feb 17;5: - PubMed
  31. Pharm Stat. 2011 Mar-Apr;10(2):128-34 - PubMed
  32. Medicine (Baltimore). 2017 Nov;96(47):e8487 - PubMed
  33. Nature. 2010 Mar 18;464(7287):427-30 - PubMed
  34. BMC Cancer. 2018 May 8;18(1):542 - PubMed
  35. Nature. 2010 Dec 16;468(7326):968-72 - PubMed
  36. Mol Cancer Ther. 2015 Dec;14(12):2700-11 - PubMed
  37. Cell. 2013 Mar 28;153(1):139-52 - PubMed
  38. Cell Prolif. 2017 Jun;50(3): - PubMed
  39. Elife. 2016 Feb 23;5: - PubMed
  40. Nature. 2010 Mar 18;464(7287):431-5 - PubMed
  41. Elife. 2014 Dec 10;3: - PubMed
  42. Elife. 2016 Mar 21;5: - PubMed
  43. Nat Chem Biol. 2013 Jul;9(7):428-36 - PubMed
  44. Front Immunol. 2019 May 07;10:990 - PubMed
  45. Mod Pathol. 2017 Jul;30(7):952-963 - PubMed
  46. BMC Med Genomics. 2019 Apr 15;12(1):54 - PubMed
  47. Oncol Lett. 2017 Mar;13(3):1665-1671 - PubMed
  48. Biochem Pharmacol. 2019 Apr;162:169-176 - PubMed
  49. Elife. 2015 Jul 31;4:e07420 - PubMed
  50. Database (Oxford). 2016 Jul 03;2016: - PubMed
  51. Elife. 2014 Dec 10;3: - PubMed
  52. Cell Rep. 2016 Nov 22;17(9):2234-2246 - PubMed
  53. Elife. 2020 May 22;9: - PubMed
  54. Cancer Res. 2004 Dec 15;64(24):9101-4 - PubMed
  55. Nature. 2017 Aug 10;548(7666):239-243 - PubMed
  56. Science. 2014 Sep 19;345(6203):1502-5 - PubMed
  57. J Pathol Transl Med. 2016 Nov;50(6):411-418 - PubMed
  58. Nature. 2012 Feb 15;483(7390):474-8 - PubMed
  59. Oncotarget. 2017 Feb 7;8(6):9251-9266 - PubMed
  60. Int J Biochem Cell Biol. 2016 Oct;79:249-260 - PubMed
  61. Nature. 2017 Aug 10;548(7666):234-238 - PubMed
  62. Cancer Discov. 2019 May;9(5):587-604 - PubMed

Publication Types