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Showing 1 to 9 of 9 entries
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Withdrawal: .

The Journal of biological chemistry

Llano E, Pendás AM, Aza-Blanc P, Kornberg TB, López-Otín C.
PMID: 30807999
J Biol Chem. 2019 Jan 25;294(4):1428. doi: 10.1074/jbc.W118.007322.

No abstract available.

Cite
Llano E, Pendás AM, Aza-Blanc P, et al. Withdrawal: . J Biol Chem. 2019;294(4):1428doi: 10.1074/jbc.W118.007322.
Llano, E., Pendás, A. M., Aza-Blanc, P., Kornberg, T. B., & López-Otín, C. (2019). Withdrawal: . The Journal of biological chemistry, 294(4), 1428. https://doi.org/10.1074/jbc.W118.007322
Llano, Elena, et al. "Withdrawal: ." The Journal of biological chemistry vol. 294,4 (2019): 1428. doi: https://doi.org/10.1074/jbc.W118.007322
Llano E, Pendás AM, Aza-Blanc P, Kornberg TB, López-Otín C. Withdrawal: . J Biol Chem. 2019 Jan 25;294(4):1428. doi: 10.1074/jbc.W118.007322. PMID: 30807999; PMCID: PMC6349128.
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Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology.

eLife

Errington TM, Denis A, Allison AB, Araiza R, Aza-Blanc P, Bower LR, Campos J, Chu H, Denson S, Donham C, Harr K, Haven B, Iorns E, Kwok J, McDonald E, Pelech S, Perfito N, Pike A, Sampey D, Settles M, Scott DA, Sharma V, Tolentino T, Trinh A, Tsui R, Willis B, Wood J, Young L.
PMID: 34874009
Elife. 2021 Dec 07;10. doi: 10.7554/eLife.73430.

As part of the Reproducibility Project: Cancer Biology, we published Registered Reports that described how we intended to replicate selected experiments from 29 high-impact preclinical cancer biology papers published between 2010 and 2012. Replication experiments were completed and Replication...

Cite
Errington TM, Denis A, Allison AB, et al. Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology. Elife. 2021;10doi: 10.7554/eLife.73430.
Errington, T. M., Denis, A., Allison, A. B., Araiza, R., Aza-Blanc, P., Bower, L. R., Campos, J., Chu, H., Denson, S., Donham, C., Harr, K., Haven, B., Iorns, E., Kwok, J., McDonald, E., Pelech, S., Perfito, N., Pike, A., Sampey, D., Settles, M., Scott, D. A., Sharma, V., Tolentino, T., Trinh, A., Tsui, R., Willis, B., Wood, J., & Young, L. (2021). Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology. eLife, 10. https://doi.org/10.7554/eLife.73430
Errington, Timothy M, et al. "Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.73430
Errington TM, Denis A, Allison AB, Araiza R, Aza-Blanc P, Bower LR, Campos J, Chu H, Denson S, Donham C, Harr K, Haven B, Iorns E, Kwok J, McDonald E, Pelech S, Perfito N, Pike A, Sampey D, Settles M, Scott DA, Sharma V, Tolentino T, Trinh A, Tsui R, Willis B, Wood J, Young L. Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology. Elife. 2021 Dec 07;10. doi: 10.7554/eLife.73430. PMID: 34874009; PMCID: PMC8651290.
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Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress.

iScience

Sanchez M, Lin Y, Yang CC, McQuary P, Rosa Campos A, Aza Blanc P, Wolf DA.
PMID: 31627132
iScience. 2019 Oct 25;20:466-480. doi: 10.1016/j.isci.2019.09.031. Epub 2019 Sep 26.

The cellular stress response triggers a cascade of events leading to transcriptional reprogramming and a transient inhibition of global protein synthesis, which is thought to be mediated by phosphorylation of eukaryotic initiation factor-2α (eIF2α). Using mouse embryonic fibroblasts (MEFs)...

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Sanchez M, Lin Y, Yang CC, et al. Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress. iScience. 2019;20:466-480doi: 10.1016/j.isci.2019.09.031.
Sanchez, M., Lin, Y., Yang, C. C., McQuary, P., Rosa Campos, A., Aza Blanc, P., & Wolf, D. A. (2019). Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress. iScience, 20466-480. https://doi.org/10.1016/j.isci.2019.09.031
Sanchez, Marisa, et al. "Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress." iScience vol. 20 (2019): 466-480. doi: https://doi.org/10.1016/j.isci.2019.09.031
Sanchez M, Lin Y, Yang CC, McQuary P, Rosa Campos A, Aza Blanc P, Wolf DA. Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress. iScience. 2019 Oct 25;20:466-480. doi: 10.1016/j.isci.2019.09.031. Epub 2019 Sep 26. PMID: 31627132; PMCID: PMC6823656.
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Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ.

Cell reports

Llado V, Nakanishi Y, Duran A, Reina-Campos M, Shelton PM, Linares JF, Yajima T, Campos A, Aza-Blanc P, Leitges M, Diaz-Meco MT, Moscat J.
PMID: 25660024
Cell Rep. 2015 Feb 10;10(5):740-754. doi: 10.1016/j.celrep.2015.01.007. Epub 2015 Feb 05.

Intestinal epithelial homeostasis requires continuous renewal supported by stem cells located in the base of the crypt. Disruption of this balance results in failure to regenerate and initiates tumorigenesis. The β-catenin and Yap pathways in Lgr5

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Llado V, Nakanishi Y, Duran A, et al. Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ. Cell Rep. 2015;10(5):740-754doi: 10.1016/j.celrep.2015.01.007.
Llado, V., Nakanishi, Y., Duran, A., Reina-Campos, M., Shelton, P. M., Linares, J. F., Yajima, T., Campos, A., Aza-Blanc, P., Leitges, M., Diaz-Meco, M. T., & Moscat, J. (2015). Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ. Cell reports, 10(5), 740-754. https://doi.org/10.1016/j.celrep.2015.01.007
Llado, Victoria, et al. "Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ." Cell reports vol. 10,5 (2015): 740-754. doi: https://doi.org/10.1016/j.celrep.2015.01.007
Llado V, Nakanishi Y, Duran A, Reina-Campos M, Shelton PM, Linares JF, Yajima T, Campos A, Aza-Blanc P, Leitges M, Diaz-Meco MT, Moscat J. Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ. Cell Rep. 2015 Feb 10;10(5):740-754. doi: 10.1016/j.celrep.2015.01.007. Epub 2015 Feb 05. PMID: 25660024; PMCID: PMC4524805.
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Targeting USP13-mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non-small cell lung cancer.

International journal of cancer

Giron P, Eggermont C, Noeparast A, Vandenplas H, Teugels E, Forsyth R, De Wever O, Aza-Blanc P, Gutierrez GJ, De Grève J.
PMID: 33210294
Int J Cancer. 2020 Nov 19; doi: 10.1002/ijc.33404. Epub 2020 Nov 19.

In non-small cell lung cancer (NSCLC), activating mutations in the epidermal growth factor receptor (EGFR) induce sensitivity to EGFR tyrosine kinase inhibitors. Despite impressive clinical responses, patients ultimately relapse as a reservoir of drug-tolerant cells persist, which ultimately leads...

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Giron P, Eggermont C, Noeparast A, et al. Targeting USP13-mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non-small cell lung cancer. Int J Cancer. 2020;doi: 10.1002/ijc.33404.
Giron, P., Eggermont, C., Noeparast, A., Vandenplas, H., Teugels, E., Forsyth, R., De Wever, O., Aza-Blanc, P., Gutierrez, G. J., & De Grève, J. (2020). Targeting USP13-mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non-small cell lung cancer. International journal of cancer, . https://doi.org/10.1002/ijc.33404
Giron, Philippe, et al. "Targeting USP13-mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non-small cell lung cancer." International journal of cancer vol. (2020). doi: https://doi.org/10.1002/ijc.33404
Giron P, Eggermont C, Noeparast A, Vandenplas H, Teugels E, Forsyth R, De Wever O, Aza-Blanc P, Gutierrez GJ, De Grève J. Targeting USP13-mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non-small cell lung cancer. Int J Cancer. 2020 Nov 19; doi: 10.1002/ijc.33404. Epub 2020 Nov 19. PMID: 33210294; PMCID: PMC8048518.
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Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance.

Cancer research

Liu J, Rebecca VW, Kossenkov AV, Connelly T, Liu Q, Gutierrez A, Xiao M, Li L, Zhang G, Samarkina A, Zayasbazan D, Zhang J, Cheng C, Wei Z, Alicea GM, Fukunaga-Kalabis M, Krepler C, Aza-Blanc P, Yang CC, Delvadia B, Tong C, Huang Y, Delvadia M, Morias AS, Sproesser K, Brafford P, Wang JX, Beqiri M, Somasundaram R, Vultur A, Hristova DM, Wu LW, Lu Y, Mills GB, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Amaravadi RK, Kwong LN, Frederick DT, Boland GM, Salvino JM, Speicher DW, Flaherty KT, Ronai ZA, Herlyn M.
PMID: 34462276
Cancer Res. 2021 Oct 15;81(20):5230-5241. doi: 10.1158/0008-5472.CAN-20-1496. Epub 2021 Aug 30.

Metastatic melanoma is challenging to clinically address. Although standard-of-care targeted therapy has high response rates in patients with BRAF-mutant melanoma, therapy relapse occurs in most cases. Intrinsically resistant melanoma cells drive therapy resistance and display molecular and biologic properties...

Cite
Liu J, Rebecca VW, Kossenkov AV, et al. Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance. Cancer Res. 2021;81(20):5230-5241doi: 10.1158/0008-5472.CAN-20-1496.
Liu, J., Rebecca, V. W., Kossenkov, A. V., Connelly, T., Liu, Q., Gutierrez, A., Xiao, M., Li, L., Zhang, G., Samarkina, A., Zayasbazan, D., Zhang, J., Cheng, C., Wei, Z., Alicea, G. M., Fukunaga-Kalabis, M., Krepler, C., Aza-Blanc, P., Yang, C. C., Delvadia, B., Tong, C., Huang, Y., Delvadia, M., Morias, A. S., Sproesser, K., Brafford, P., Wang, J. X., Beqiri, M., Somasundaram, R., Vultur, A., Hristova, D. M., Wu, L. W., Lu, Y., Mills, G. B., Xu, W., Karakousis, G. C., Xu, X., Schuchter, L. M., Mitchell, T. C., Amaravadi, R. K., Kwong, L. N., Frederick, D. T., Boland, G. M., Salvino, J. M., Speicher, D. W., Flaherty, K. T., Ronai, Z. A., & Herlyn, M. (2021). Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance. Cancer research, 81(20), 5230-5241. https://doi.org/10.1158/0008-5472.CAN-20-1496
Liu, Jianglan, et al. "Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance." Cancer research vol. 81,20 (2021): 5230-5241. doi: https://doi.org/10.1158/0008-5472.CAN-20-1496
Liu J, Rebecca VW, Kossenkov AV, Connelly T, Liu Q, Gutierrez A, Xiao M, Li L, Zhang G, Samarkina A, Zayasbazan D, Zhang J, Cheng C, Wei Z, Alicea GM, Fukunaga-Kalabis M, Krepler C, Aza-Blanc P, Yang CC, Delvadia B, Tong C, Huang Y, Delvadia M, Morias AS, Sproesser K, Brafford P, Wang JX, Beqiri M, Somasundaram R, Vultur A, Hristova DM, Wu LW, Lu Y, Mills GB, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Amaravadi RK, Kwong LN, Frederick DT, Boland GM, Salvino JM, Speicher DW, Flaherty KT, Ronai ZA, Herlyn M. Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance. Cancer Res. 2021 Oct 15;81(20):5230-5241. doi: 10.1158/0008-5472.CAN-20-1496. Epub 2021 Aug 30. PMID: 34462276; PMCID: PMC8530965.
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Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology.

eLife

Errington TM, Denis A, Allison AB, Araiza R, Aza-Blanc P, Bower LR, Campos J, Chu H, Denson S, Donham C, Harr K, Haven B, Iorns E, Kwok J, McDonald E, Pelech S, Perfito N, Pike A, Sampey D, Settles M, Scott DA, Sharma V, Tolentino T, Trinh A, Tsui R, Willis B, Wood J, Young L.
PMID: 34874009
Elife. 2021 Dec 07;10. doi: 10.7554/eLife.73430.

As part of the Reproducibility Project: Cancer Biology, we published Registered Reports that described how we intended to replicate selected experiments from 29 high-impact preclinical cancer biology papers published between 2010 and 2012. Replication experiments were completed and Replication...

Cite
Errington TM, Denis A, Allison AB, et al. Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology. Elife. 2021;10doi: 10.7554/eLife.73430.
Errington, T. M., Denis, A., Allison, A. B., Araiza, R., Aza-Blanc, P., Bower, L. R., Campos, J., Chu, H., Denson, S., Donham, C., Harr, K., Haven, B., Iorns, E., Kwok, J., McDonald, E., Pelech, S., Perfito, N., Pike, A., Sampey, D., Settles, M., Scott, D. A., Sharma, V., Tolentino, T., Trinh, A., Tsui, R., Willis, B., Wood, J., & Young, L. (2021). Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology. eLife, 10. https://doi.org/10.7554/eLife.73430
Errington, Timothy M, et al. "Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.73430
Errington TM, Denis A, Allison AB, Araiza R, Aza-Blanc P, Bower LR, Campos J, Chu H, Denson S, Donham C, Harr K, Haven B, Iorns E, Kwok J, McDonald E, Pelech S, Perfito N, Pike A, Sampey D, Settles M, Scott DA, Sharma V, Tolentino T, Trinh A, Tsui R, Willis B, Wood J, Young L. Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology. Elife. 2021 Dec 07;10. doi: 10.7554/eLife.73430. PMID: 34874009; PMCID: PMC8651290.
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Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance.

Cancer research

Liu J, Rebecca VW, Kossenkov AV, Connelly T, Liu Q, Gutierrez A, Xiao M, Li L, Zhang G, Samarkina A, Zayasbazan D, Zhang J, Cheng C, Wei Z, Alicea GM, Fukunaga-Kalabis M, Krepler C, Aza-Blanc P, Yang CC, Delvadia B, Tong C, Huang Y, Delvadia M, Morias AS, Sproesser K, Brafford P, Wang JX, Beqiri M, Somasundaram R, Vultur A, Hristova DM, Wu LW, Lu Y, Mills GB, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Amaravadi RK, Kwong LN, Frederick DT, Boland GM, Salvino JM, Speicher DW, Flaherty KT, Ronai ZA, Herlyn M.
PMID: 34462276
Cancer Res. 2021 Oct 15;81(20):5230-5241. doi: 10.1158/0008-5472.CAN-20-1496. Epub 2021 Aug 30.

Metastatic melanoma is challenging to clinically address. Although standard-of-care targeted therapy has high response rates in patients with BRAF-mutant melanoma, therapy relapse occurs in most cases. Intrinsically resistant melanoma cells drive therapy resistance and display molecular and biologic properties...

Cite
Liu J, Rebecca VW, Kossenkov AV, et al. Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance. Cancer Res. 2021;81(20):5230-5241doi: 10.1158/0008-5472.CAN-20-1496.
Liu, J., Rebecca, V. W., Kossenkov, A. V., Connelly, T., Liu, Q., Gutierrez, A., Xiao, M., Li, L., Zhang, G., Samarkina, A., Zayasbazan, D., Zhang, J., Cheng, C., Wei, Z., Alicea, G. M., Fukunaga-Kalabis, M., Krepler, C., Aza-Blanc, P., Yang, C. C., Delvadia, B., Tong, C., Huang, Y., Delvadia, M., Morias, A. S., Sproesser, K., Brafford, P., Wang, J. X., Beqiri, M., Somasundaram, R., Vultur, A., Hristova, D. M., Wu, L. W., Lu, Y., Mills, G. B., Xu, W., Karakousis, G. C., Xu, X., Schuchter, L. M., Mitchell, T. C., Amaravadi, R. K., Kwong, L. N., Frederick, D. T., Boland, G. M., Salvino, J. M., Speicher, D. W., Flaherty, K. T., Ronai, Z. A., & Herlyn, M. (2021). Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance. Cancer research, 81(20), 5230-5241. https://doi.org/10.1158/0008-5472.CAN-20-1496
Liu, Jianglan, et al. "Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance." Cancer research vol. 81,20 (2021): 5230-5241. doi: https://doi.org/10.1158/0008-5472.CAN-20-1496
Liu J, Rebecca VW, Kossenkov AV, Connelly T, Liu Q, Gutierrez A, Xiao M, Li L, Zhang G, Samarkina A, Zayasbazan D, Zhang J, Cheng C, Wei Z, Alicea GM, Fukunaga-Kalabis M, Krepler C, Aza-Blanc P, Yang CC, Delvadia B, Tong C, Huang Y, Delvadia M, Morias AS, Sproesser K, Brafford P, Wang JX, Beqiri M, Somasundaram R, Vultur A, Hristova DM, Wu LW, Lu Y, Mills GB, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Amaravadi RK, Kwong LN, Frederick DT, Boland GM, Salvino JM, Speicher DW, Flaherty KT, Ronai ZA, Herlyn M. Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance. Cancer Res. 2021 Oct 15;81(20):5230-5241. doi: 10.1158/0008-5472.CAN-20-1496. Epub 2021 Aug 30. PMID: 34462276; PMCID: PMC8530965.
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TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.

Cell death & disease

Woznicki JA, Saini N, Flood P, Rajaram S, Lee CM, Stamou P, Skowyra A, Bustamante-Garrido M, Regazzoni K, Crawford N, McDade SS, Longley DB, Aza-Blanc P, Shanahan F, Zulquernain SA, McCarthy J, Melgar S, McRae BL, Nally K.
PMID: 34556638
Cell Death Dis. 2021 Sep 23;12(10):864. doi: 10.1038/s41419-021-04151-3.

Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn's disease (CD). Th1-type cytokines-IFN-γ and TNF-α-occupy critical nodes within these networks and both are associated with disruption of gut epithelial barrier function....

Cite
Woznicki JA, Saini N, Flood P, et al. TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells. Cell Death Dis. 2021;12(10):864doi: 10.1038/s41419-021-04151-3.
Woznicki, J. A., Saini, N., Flood, P., Rajaram, S., Lee, C. M., Stamou, P., Skowyra, A., Bustamante-Garrido, M., Regazzoni, K., Crawford, N., McDade, S. S., Longley, D. B., Aza-Blanc, P., Shanahan, F., Zulquernain, S. A., McCarthy, J., Melgar, S., McRae, B. L., & Nally, K. (2021). TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells. Cell death & disease, 12(10), 864. https://doi.org/10.1038/s41419-021-04151-3
Woznicki, Jerzy A, et al. "TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells." Cell death & disease vol. 12,10 (2021): 864. doi: https://doi.org/10.1038/s41419-021-04151-3
Woznicki JA, Saini N, Flood P, Rajaram S, Lee CM, Stamou P, Skowyra A, Bustamante-Garrido M, Regazzoni K, Crawford N, McDade SS, Longley DB, Aza-Blanc P, Shanahan F, Zulquernain SA, McCarthy J, Melgar S, McRae BL, Nally K. TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells. Cell Death Dis. 2021 Sep 23;12(10):864. doi: 10.1038/s41419-021-04151-3. PMID: 34556638; PMCID: PMC8459343.
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