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Li N, Gong YC, Chen J. A meta-analysis of the therapeutic effect of intranasal salmon calcitonin on osteoporosis. Eur J Med Res. 2021;26(1):140doi: 10.1186/s40001-021-00610-x.
Li, N., Gong, Y. C., & Chen, J. (2021). A meta-analysis of the therapeutic effect of intranasal salmon calcitonin on osteoporosis. European journal of medical research, 26(1), 140. https://doi.org/10.1186/s40001-021-00610-x
Li, Ning, et al. "A meta-analysis of the therapeutic effect of intranasal salmon calcitonin on osteoporosis." European journal of medical research vol. 26,1 (2021): 140. doi: https://doi.org/10.1186/s40001-021-00610-x
Li N, Gong YC, Chen J. A meta-analysis of the therapeutic effect of intranasal salmon calcitonin on osteoporosis. Eur J Med Res. 2021 Dec 08;26(1):140. doi: 10.1186/s40001-021-00610-x. PMID: 34879875; PMCID: PMC8653544.
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Eur J Med Res. 2021 Dec 08;26(1):140. doi: 10.1186/s40001-021-00610-x.

A meta-analysis of the therapeutic effect of intranasal salmon calcitonin on osteoporosis.

European journal of medical research

Ning Li, Yi Chen Gong, Jianer Chen

Affiliations

  1. Zhejiang Rehabilitation Medical Center (Rehabilitation Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine), Zhejiang, China. [email protected].
  2. Zhejiang Rehabilitation Medical Center (Rehabilitation Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine), Zhejiang, China.

PMID: 34879875 PMCID: PMC8653544 DOI: 10.1186/s40001-021-00610-x

Abstract

OBJECTIVE: To evaluate the efficacy and safety of intranasal salmon calcitonin in the treatment of osteoporosis.

METHODS: Eight Chinese and English databases were searched by electronic search (from the establishment of the database to October 2019). The literature was screened according to the inclusion criteria and exclusion criteria, the quality was evaluated according to Cochrane software, and the Review Manager 5.2 software was used for statistical analysis.

RESULTS: A total of 374 documents were retrieved and 12 (12 original studies) were included after the screening, with a total sample capacity of 1068 cases. Meta-analysis showed that the intranasal salmon calcitonin had obvious advantages in reducing blood calcium, improving the ratio of serum creatinine and alkaline phosphatase. In addition, the intranasal salmon calcitonin had no obvious advantages in other indicators. It cannot be illustrated that the combination of intranasal salmon calcitonin and other conventional drugs is more effective than the simple use of conventional drugs.

CONCLUSION: The intranasal salmon calcitonin is superior to conventional drugs in reducing blood calcium, increasing creatinine ratio, and alkaline phosphatase, but its advantages in other indicators such as improving the bone mineral density (BMD) of lumbar vertebrae and hip have not been confirmed, and it is not clear that the combination of intranasal salmon calcitonin and other conventional drugs is better than the simple conventional drugs.

© 2021. The Author(s).

Keywords: Intranasal salmon calcitonin; Meta-analysis; Osteoporosis

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