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Song X, Li N, Liu Y, et al. CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer. Transl Oncol. 2021;15(1):101306doi: 10.1016/j.tranon.2021.101306.
Song, X., Li, N., Liu, Y., Wang, Z., Wang, T., Tan, S., Li, C., Qiu, C., Gao, L., Asano, K., Tanaka, M., Liang, X., Liu, X., & Ma, C. (2022). CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer. Translational oncology, 15(1), 101306. https://doi.org/10.1016/j.tranon.2021.101306
Song, Xiaojia, et al. "CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer." Translational oncology vol. 15,1 (2022): 101306. doi: https://doi.org/10.1016/j.tranon.2021.101306
Song X, Li N, Liu Y, Wang Z, Wang T, Tan S, Li C, Qiu C, Gao L, Asano K, Tanaka M, Liang X, Liu X, Ma C. CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer. Transl Oncol. 2022 Jan;15(1):101306. doi: 10.1016/j.tranon.2021.101306. Epub 2021 Dec 06. PMID: 34883446.
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Transl Oncol. 2022 Jan;15(1):101306. doi: 10.1016/j.tranon.2021.101306. Epub 2021 Dec 06.

CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer.

Translational oncology

Xiaojia Song, Na Li, Yuan Liu, Zehua Wang, Tixiao Wang, Siyu Tan, Chunyang Li, Chunhong Qiu, Lifen Gao, Kenichi Asano, Masato Tanaka, Xiaohong Liang, Xinyong Liu, Chunhong Ma

Affiliations

  1. Department of Medicinal Chemistry and Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China; Key Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province, and Department of Immunology, School of Basic Medical Sciences, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012, China.
  2. Key Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province, and Department of Immunology, School of Basic Medical Sciences, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012, China.
  3. Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  4. Department of Clinical Laboratory, Qilu Hospital of Shandong University, Qingdao, Shandong, China.
  5. Laboratory of Immune Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Science, Tokyo, Japan.
  6. Department of Medicinal Chemistry and Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
  7. Key Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province, and Department of Immunology, School of Basic Medical Sciences, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012, China. Electronic address: [email protected].

PMID: 34883446 DOI: 10.1016/j.tranon.2021.101306

Abstract

Radiofrequency ablation (RFA) is a widely used and effective treatment for primary or metastatic liver cancer with small-size lesions. However, the therapeutic effectiveness of RFA in controlling metastatic lesion or recurrence is still limited. As the major cell population in tumor microenvironment (TME), macrophages have been reported to be recruited to RFA-treated lesion, but their roles are still unclear. Herein, we successfully established the mouse model mimicking RFA-induced abscopal effect, in which RFA eliminated the local orthotopic liver tumor but failed to control growth of distant tumor. Correspondently, RFA suppressed protumoral activation of local tumor-associated macrophages (TAMs), but failed to reprogram TAMs in distance. Importantly, although RFA led to reduced proportion of hepatic CD169

Copyright © 2021. Published by Elsevier Inc.

Keywords: Abscopal effect; CD169(+) macrophages; Cell transfer; Liver cancer; Radiofrequency ablation

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