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Mirzaei A, Shahrestanaki E, Daneshzad E, et al. Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis. J Diabetes Metab Disord. 2021;20(2):1327-1336doi: 10.1007/s40200-021-00861-9.
Mirzaei, A., Shahrestanaki, E., Daneshzad, E., Heshmati, J., Djalalinia, S., Asayesh, H., Mahdavi-Gorabi, A., Heshmat, R., & Qorbani, M. (2021). Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis. Journal of diabetes and metabolic disorders, 20(2), 1327-1336. https://doi.org/10.1007/s40200-021-00861-9
Mirzaei, Ahmadreza, et al. "Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis." Journal of diabetes and metabolic disorders vol. 20,2 (2021): 1327-1336. doi: https://doi.org/10.1007/s40200-021-00861-9
Mirzaei A, Shahrestanaki E, Daneshzad E, Heshmati J, Djalalinia S, Asayesh H, Mahdavi-Gorabi A, Heshmat R, Qorbani M. Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis. J Diabetes Metab Disord. 2021 Aug 11;20(2):1327-1336. doi: 10.1007/s40200-021-00861-9. eCollection 2021 Dec. PMID: 34900784; PMCID: PMC8630338.
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J Diabetes Metab Disord. 2021 Aug 11;20(2):1327-1336. doi: 10.1007/s40200-021-00861-9. eCollection 2021 Dec.

Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis.

Journal of diabetes and metabolic disorders

Ahmadreza Mirzaei, Ehsan Shahrestanaki, Elnaz Daneshzad, Javad Heshmati, Shirin Djalalinia, Hamid Asayesh, Armita Mahdavi-Gorabi, Ramin Heshmat, Mostafa Qorbani

Affiliations

  1. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
  2. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
  3. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
  4. Songhor Healthcare Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  5. Development of Research & Technology Center, Ministry of Health and Medical Education, Tehran, Iran.
  6. Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran.
  7. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  8. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 34900784 PMCID: PMC8630338 DOI: 10.1007/s40200-021-00861-9

Abstract

PURPOSE: The aim of this updated systematic review and meta-analysis was the association between hyperglycemia and periodontitis.

METHODS: We searched PubMed/MEDLINE, Web of Science, and Scopus until March 2021. The key search words were based on "periodontitis" and "hyperglycemia." We included cohort, case-control, and cross-sectional studies, restricted to publications in English. The quality assessment of included studies and data extraction were done by two independent reviewers. Meta-analysis was performed for cross-sectional studies using the random-effects model.

RESULTS: The literature search yielded 340 studies, and finally, 19 and 11 studies were included in systematic review and meta-analysis, respectively. The total sample size of the eligible studies in the meta-analysis was 38,896 participants, of whom 33% were male with a mean age of 51.20 ± 14.0 years. According to a random-effect meta-analysis in cross-sectional studies, the pooled odds ratio (OR) for the association between hyperglycemia and periodontal indices was statistically significant (OR: 1.50, 95%CI: 1.11, 1.90). There was evidence of publication bias (coefficient: - 3.53, p-value = 0.014) which, after imputing missing studies, the pooled OR of the association between hyperglycemia and periodontitis change to 1.55 (95%CI: 1.20, 1.90).

CONCLUSION: Results of the present study show that hyperglycemia was positively associated with periodontitis. However, more cohort and prospective longitudinal studies should be conducted to find the exact association. Overall, it seems the management of hyperglycemia could be considered as a preventive strategy for periodontitis.

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40200-021-00861-9.

© Springer Nature Switzerland AG 2021.

Keywords: Hyperglycemic; Meta-Analysis; Metabolic Syndrome; Periodontitis; Systematic Review

Conflict of interest statement

Conflict of interestNot applicable.

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