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Prevalence of cardio-metabolic risk factors in a nationally representative sample of Iranian adolescents: The CASPIAN-III Study.

Journal of cardiovascular and thoracic research

Kelishadi R, Heshmat R, Farzadfar F, Esmaeil Motlag M, Bahreynian M, Safiri S, Ardalan G, Rezaei Darzi E, Asayesh H, Rezaei F, Qorbani M.
PMID: 28451083
J Cardiovasc Thorac Res. 2017;9(1):12-20. doi: 10.15171/jcvtr.2017.02. Epub 2017 Mar 13.

No abstract available.

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Kelishadi R, Heshmat R, Farzadfar F, et al. Prevalence of cardio-metabolic risk factors in a nationally representative sample of Iranian adolescents: The CASPIAN-III Study. J Cardiovasc Thorac Res. 2017;9(1):12-20doi: 10.15171/jcvtr.2017.02.
Kelishadi, R., Heshmat, R., Farzadfar, F., Esmaeil Motlag, M., Bahreynian, M., Safiri, S., Ardalan, G., Rezaei Darzi, E., Asayesh, H., Rezaei, F., & Qorbani, M. (2017). Prevalence of cardio-metabolic risk factors in a nationally representative sample of Iranian adolescents: The CASPIAN-III Study. Journal of cardiovascular and thoracic research, 9(1), 12-20. https://doi.org/10.15171/jcvtr.2017.02
Kelishadi, Roya, et al. "Prevalence of cardio-metabolic risk factors in a nationally representative sample of Iranian adolescents: The CASPIAN-III Study." Journal of cardiovascular and thoracic research vol. 9,1 (2017): 12-20. doi: https://doi.org/10.15171/jcvtr.2017.02
Kelishadi R, Heshmat R, Farzadfar F, Esmaeil Motlag M, Bahreynian M, Safiri S, Ardalan G, Rezaei Darzi E, Asayesh H, Rezaei F, Qorbani M. Prevalence of cardio-metabolic risk factors in a nationally representative sample of Iranian adolescents: The CASPIAN-III Study. J Cardiovasc Thorac Res. 2017;9(1):12-20. doi: 10.15171/jcvtr.2017.02. Epub 2017 Mar 13. PMID: 28451083; PMCID: PMC5402022.
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Association of some psychosocial factors with anthropometric measures in nationally representative sample of Iranian adolescents: the CASPIAN-III study.

Journal of diabetes and metabolic disorders

Baygi F, Kelishadi R, Qorbani M, Mohammadi F, Motlagh ME, Ardalan G, Mansourian M, Arzaghi SM, Asayesh H, Heshmat R.
PMID: 27252934
J Diabetes Metab Disord. 2016 Jun 01;15:15. doi: 10.1186/s40200-016-0237-7. eCollection 2015.

BACKGROUND: During the last two decades, adolescent obesity has increased in western countries. In Iran-as a developing country- the prevalence of obesity is raised among youngsters as well. This study conducted to identify an association of adolescents' loneliness, self-confidence...

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Baygi F, Kelishadi R, Qorbani M, et al. Association of some psychosocial factors with anthropometric measures in nationally representative sample of Iranian adolescents: the CASPIAN-III study. J Diabetes Metab Disord. 2016;15:15doi: 10.1186/s40200-016-0237-7.
Baygi, F., Kelishadi, R., Qorbani, M., Mohammadi, F., Motlagh, M. E., Ardalan, G., Mansourian, M., Arzaghi, S. M., Asayesh, H., & Heshmat, R. (2015). Association of some psychosocial factors with anthropometric measures in nationally representative sample of Iranian adolescents: the CASPIAN-III study. Journal of diabetes and metabolic disorders, 1515. https://doi.org/10.1186/s40200-016-0237-7
Baygi, Fereshteh, et al. "Association of some psychosocial factors with anthropometric measures in nationally representative sample of Iranian adolescents: the CASPIAN-III study." Journal of diabetes and metabolic disorders vol. 15 (2015): 15. doi: https://doi.org/10.1186/s40200-016-0237-7
Baygi F, Kelishadi R, Qorbani M, Mohammadi F, Motlagh ME, Ardalan G, Mansourian M, Arzaghi SM, Asayesh H, Heshmat R. Association of some psychosocial factors with anthropometric measures in nationally representative sample of Iranian adolescents: the CASPIAN-III study. J Diabetes Metab Disord. 2016 Jun 01;15:15. doi: 10.1186/s40200-016-0237-7. eCollection 2015. PMID: 27252934; PMCID: PMC4888475.
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Collaboration in research and the influential factors in Golestan University of Medical Sciences research projects (2005-2007): an academic sample from Iran.

Medical journal of the Islamic Republic of Iran

Borghei A, Qorbani M, Rezapour A, Majdzadeh R, Nedjat S, Asayesh H, Mansourian M, Noroozi M, Jahahgir F.
PMID: 24791118
Med J Islam Repub Iran. 2013 Aug;27(3):101-8.

BACKGROUND: Number of Iranian articles published in ISI journals has increased significantly in recent years.Despite the quantitative progress, studies performed in Iran represent low collaboration in research; therefore,we decided to evaluate collaboration in Golestan University of Medical Sciences (GOUMS)...

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Borghei A, Qorbani M, Rezapour A, et al. Collaboration in research and the influential factors in Golestan University of Medical Sciences research projects (2005-2007): an academic sample from Iran. Med J Islam Repub Iran. 2013;27(3):101-8
Borghei, A., Qorbani, M., Rezapour, A., Majdzadeh, R., Nedjat, S., Asayesh, H., Mansourian, M., Noroozi, M., & Jahahgir, F. (2013). Collaboration in research and the influential factors in Golestan University of Medical Sciences research projects (2005-2007): an academic sample from Iran. Medical journal of the Islamic Republic of Iran, 27(3), 101-8.
Borghei, Afsaneh, et al. "Collaboration in research and the influential factors in Golestan University of Medical Sciences research projects (2005-2007): an academic sample from Iran." Medical journal of the Islamic Republic of Iran vol. 27,3 (2013): 101-8.
Borghei A, Qorbani M, Rezapour A, Majdzadeh R, Nedjat S, Asayesh H, Mansourian M, Noroozi M, Jahahgir F. Collaboration in research and the influential factors in Golestan University of Medical Sciences research projects (2005-2007): an academic sample from Iran. Med J Islam Repub Iran. 2013 Aug;27(3):101-8. PMID: 24791118; PMCID: PMC3917486.
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Effect of nanocrystalline hydroxyapatite socket preservation on orthodontically induced inflammatory root resorption.

Cell journal

Seifi M, Arayesh A, Shamloo N, Hamedi R.
PMID: 25685742
Cell J. 2015;16(4):514-27. doi: 10.22074/cellj.2015.496. Epub 2015 Jan 13.

OBJECTIVE: Orthodontically induced inflammatory root resorption (OIIRR) is considered to be an important sequel associated with orthodontic tooth movement (OTM). OTM after Socket preservation enhances the periodontal condition before orthodontic space closure. The purpose of this study is to...

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Seifi M, Arayesh A, Shamloo N, et al. Effect of nanocrystalline hydroxyapatite socket preservation on orthodontically induced inflammatory root resorption. Cell J. 2015;16(4):514-27doi: 10.22074/cellj.2015.496.
Seifi, M., Arayesh, A., Shamloo, N., & Hamedi, R. (2015). Effect of nanocrystalline hydroxyapatite socket preservation on orthodontically induced inflammatory root resorption. Cell journal, 16(4), 514-27. https://doi.org/10.22074/cellj.2015.496
Seifi, Massoud, et al. "Effect of nanocrystalline hydroxyapatite socket preservation on orthodontically induced inflammatory root resorption." Cell journal vol. 16,4 (2015): 514-27. doi: https://doi.org/10.22074/cellj.2015.496
Seifi M, Arayesh A, Shamloo N, Hamedi R. Effect of nanocrystalline hydroxyapatite socket preservation on orthodontically induced inflammatory root resorption. Cell J. 2015;16(4):514-27. doi: 10.22074/cellj.2015.496. Epub 2015 Jan 13. PMID: 25685742; PMCID: PMC4297490.
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A nationwide report on blood pressure of children and adolescents according to socioeconomic status: The CASPIAN-IV study.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Fallah Z, Kelishadi R, Heshmat R, Motlagh ME, Ardalan G, Kasaeian A, Asayesh H, Qorbani M.
PMID: 26622253
J Res Med Sci. 2015 Jul;20(7):646-55. doi: 10.4103/1735-1995.166210.

BACKGROUND: Hypertension is a major leading factor for global burden of diseases. Blood pressure (BP) tracks from childhood to adulthood. So, it is important to investigate its aff ecting factors. In this study we aimed to compare the BP...

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Fallah Z, Kelishadi R, Heshmat R, et al. A nationwide report on blood pressure of children and adolescents according to socioeconomic status: The CASPIAN-IV study. J Res Med Sci. 2015;20(7):646-55doi: 10.4103/1735-1995.166210.
Fallah, Z., Kelishadi, R., Heshmat, R., Motlagh, M. E., Ardalan, G., Kasaeian, A., Asayesh, H., & Qorbani, M. (2015). A nationwide report on blood pressure of children and adolescents according to socioeconomic status: The CASPIAN-IV study. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 20(7), 646-55. https://doi.org/10.4103/1735-1995.166210
Fallah, Zahra, et al. "A nationwide report on blood pressure of children and adolescents according to socioeconomic status: The CASPIAN-IV study." Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences vol. 20,7 (2015): 646-55. doi: https://doi.org/10.4103/1735-1995.166210
Fallah Z, Kelishadi R, Heshmat R, Motlagh ME, Ardalan G, Kasaeian A, Asayesh H, Qorbani M. A nationwide report on blood pressure of children and adolescents according to socioeconomic status: The CASPIAN-IV study. J Res Med Sci. 2015 Jul;20(7):646-55. doi: 10.4103/1735-1995.166210. PMID: 26622253; PMCID: PMC4638066.
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Is the association of continuous metabolic syndrome risk score with body mass index independent of physical activity? The CASPIAN-III study.

Nutrition research and practice

Heshmat R, Shafiee G, Kelishadi R, Babaki AE, Motlagh ME, Arefirad T, Ardalan G, Ataie-Jafari A, Asayesh H, Mohammadi R, Qorbani M.
PMID: 26244080
Nutr Res Pract. 2015 Aug;9(4):404-10. doi: 10.4162/nrp.2015.9.4.404. Epub 2015 Jul 27.

BACKGROUND/OBJECTIVES: Although the association of body mass index (BMI) with metabolic syndrome (MetS) is well documented, there is little knowledge on the independent and joint associations of BMI and physical activity with MetS risk based on a continuous scoring...

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Heshmat R, Shafiee G, Kelishadi R, et al. Is the association of continuous metabolic syndrome risk score with body mass index independent of physical activity? The CASPIAN-III study. Nutr Res Pract. 2015;9(4):404-10doi: 10.4162/nrp.2015.9.4.404.
Heshmat, R., Shafiee, G., Kelishadi, R., Babaki, A. E., Motlagh, M. E., Arefirad, T., Ardalan, G., Ataie-Jafari, A., Asayesh, H., Mohammadi, R., & Qorbani, M. (2015). Is the association of continuous metabolic syndrome risk score with body mass index independent of physical activity? The CASPIAN-III study. Nutrition research and practice, 9(4), 404-10. https://doi.org/10.4162/nrp.2015.9.4.404
Heshmat, Ramin, et al. "Is the association of continuous metabolic syndrome risk score with body mass index independent of physical activity? The CASPIAN-III study." Nutrition research and practice vol. 9,4 (2015): 404-10. doi: https://doi.org/10.4162/nrp.2015.9.4.404
Heshmat R, Shafiee G, Kelishadi R, Babaki AE, Motlagh ME, Arefirad T, Ardalan G, Ataie-Jafari A, Asayesh H, Mohammadi R, Qorbani M. Is the association of continuous metabolic syndrome risk score with body mass index independent of physical activity? The CASPIAN-III study. Nutr Res Pract. 2015 Aug;9(4):404-10. doi: 10.4162/nrp.2015.9.4.404. Epub 2015 Jul 27. PMID: 26244080; PMCID: PMC4523485.
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Diabetes mellitus, thyroid dysfunctions and osteoporosis: is there an association?.

Journal of diabetes and metabolic disorders

Qorbani M, Bazrafshan HR, Aghaei M, Dashti HS, Rezapour A, Asayesh H, Mohammadi R, Mohammadi Y, Ansari H, Mansourian M.
PMID: 23834744
J Diabetes Metab Disord. 2013 Jul 08;12(1):38. doi: 10.1186/2251-6581-12-38.

BACKGROUND: Osteoporosis is the most common metabolic bone disease with complicated, multifactorial and heterogenic nature that has no known pathological cause. As the role of Diabetes Mellitus (DM) and thyroid dysfunctions in the prevalence of osteoporosis is not exactly...

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Qorbani M, Bazrafshan HR, Aghaei M, et al. Diabetes mellitus, thyroid dysfunctions and osteoporosis: is there an association?. J Diabetes Metab Disord. 2013;12(1):38doi: 10.1186/2251-6581-12-38.
Qorbani, M., Bazrafshan, H. R., Aghaei, M., Dashti, H. S., Rezapour, A., Asayesh, H., Mohammadi, R., Mohammadi, Y., Ansari, H., & Mansourian, M. (2013). Diabetes mellitus, thyroid dysfunctions and osteoporosis: is there an association?. Journal of diabetes and metabolic disorders, 12(1), 38. https://doi.org/10.1186/2251-6581-12-38
Qorbani, Mostafa, et al. "Diabetes mellitus, thyroid dysfunctions and osteoporosis: is there an association?." Journal of diabetes and metabolic disorders vol. 12,1 (2013): 38. doi: https://doi.org/10.1186/2251-6581-12-38
Qorbani M, Bazrafshan HR, Aghaei M, Dashti HS, Rezapour A, Asayesh H, Mohammadi R, Mohammadi Y, Ansari H, Mansourian M. Diabetes mellitus, thyroid dysfunctions and osteoporosis: is there an association?. J Diabetes Metab Disord. 2013 Jul 08;12(1):38. doi: 10.1186/2251-6581-12-38. PMID: 23834744; PMCID: PMC7983611.
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Association between psychosocial distress with cardio metabolic risk factors and liver enzymes in a nationally-representative sample of Iranian children and adolescents: the CASPIAN-III study.

Journal of diabetes and metabolic disorders

Qorbani M, Kelishadi R, Taheri E, Motlagh ME, Arzaghi SM, Ardalan G, Chinian M, Mahmoudarabi M, Rezapoor A, Asayesh H, Larijani B, Amini MR, Heshmat R.
PMID: 24602504
J Diabetes Metab Disord. 2014 Mar 06;13(1):44. doi: 10.1186/2251-6581-13-44.

BACKGROUND: The present study was designed to evaluate association of psychosocial distress with cardio metabolic risk factors and liver enzymes in Iranian children and adolescents.METHOD: This nationwide study was conducted as the third survey of the school-based surveillance system...

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Qorbani M, Kelishadi R, Taheri E, et al. Association between psychosocial distress with cardio metabolic risk factors and liver enzymes in a nationally-representative sample of Iranian children and adolescents: the CASPIAN-III study. J Diabetes Metab Disord. 2014;13(1):44doi: 10.1186/2251-6581-13-44.
Qorbani, M., Kelishadi, R., Taheri, E., Motlagh, M. E., Arzaghi, S. M., Ardalan, G., Chinian, M., Mahmoudarabi, M., Rezapoor, A., Asayesh, H., Larijani, B., Amini, M. R., & Heshmat, R. (2014). Association between psychosocial distress with cardio metabolic risk factors and liver enzymes in a nationally-representative sample of Iranian children and adolescents: the CASPIAN-III study. Journal of diabetes and metabolic disorders, 13(1), 44. https://doi.org/10.1186/2251-6581-13-44
Qorbani, Mostafa, et al. "Association between psychosocial distress with cardio metabolic risk factors and liver enzymes in a nationally-representative sample of Iranian children and adolescents: the CASPIAN-III study." Journal of diabetes and metabolic disorders vol. 13,1 (2014): 44. doi: https://doi.org/10.1186/2251-6581-13-44
Qorbani M, Kelishadi R, Taheri E, Motlagh ME, Arzaghi SM, Ardalan G, Chinian M, Mahmoudarabi M, Rezapoor A, Asayesh H, Larijani B, Amini MR, Heshmat R. Association between psychosocial distress with cardio metabolic risk factors and liver enzymes in a nationally-representative sample of Iranian children and adolescents: the CASPIAN-III study. J Diabetes Metab Disord. 2014 Mar 06;13(1):44. doi: 10.1186/2251-6581-13-44. PMID: 24602504; PMCID: PMC3975638.
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Wirksamkeit von topischem Koffein bei androgenetischer Alopezie des Mannes.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

Dressler C, Blumeyer A, Rosumeck S, Arayesh A, Nast A.
PMID: 28677184
J Dtsch Dermatol Ges. 2017 Jul;15(7):734-741. doi: 10.1111/ddg.13271_g.

No abstract available.

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Dressler C, Blumeyer A, Rosumeck S, et al. Wirksamkeit von topischem Koffein bei androgenetischer Alopezie des Mannes. J Dtsch Dermatol Ges. 2017;15(7):734-741doi: 10.1111/ddg.13271_g.
Dressler, C., Blumeyer, A., Rosumeck, S., Arayesh, A., & Nast, A. (2017). Wirksamkeit von topischem Koffein bei androgenetischer Alopezie des Mannes. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 15(7), 734-741. https://doi.org/10.1111/ddg.13271_g
Dressler, Corinna, et al. "Wirksamkeit von topischem Koffein bei androgenetischer Alopezie des Mannes." Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG vol. 15,7 (2017): 734-741. doi: https://doi.org/10.1111/ddg.13271_g
Dressler C, Blumeyer A, Rosumeck S, Arayesh A, Nast A. Wirksamkeit von topischem Koffein bei androgenetischer Alopezie des Mannes. J Dtsch Dermatol Ges. 2017 Jul;15(7):734-741. doi: 10.1111/ddg.13271_g. PMID: 28677184.
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Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis.

Journal of diabetes and metabolic disorders

Mirzaei A, Shahrestanaki E, Daneshzad E, Heshmati J, Djalalinia S, Asayesh H, Mahdavi-Gorabi A, Heshmat R, Qorbani M.
PMID: 34900784
J Diabetes Metab Disord. 2021 Aug 11;20(2):1327-1336. doi: 10.1007/s40200-021-00861-9. eCollection 2021 Dec.

PURPOSE: The aim of this updated systematic review and meta-analysis was the association between hyperglycemia and periodontitis.METHODS: We searched PubMed/MEDLINE, Web of Science, and Scopus until March 2021. The key search words were based on "periodontitis" and "hyperglycemia." We...

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Mirzaei A, Shahrestanaki E, Daneshzad E, et al. Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis. J Diabetes Metab Disord. 2021;20(2):1327-1336doi: 10.1007/s40200-021-00861-9.
Mirzaei, A., Shahrestanaki, E., Daneshzad, E., Heshmati, J., Djalalinia, S., Asayesh, H., Mahdavi-Gorabi, A., Heshmat, R., & Qorbani, M. (2021). Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis. Journal of diabetes and metabolic disorders, 20(2), 1327-1336. https://doi.org/10.1007/s40200-021-00861-9
Mirzaei, Ahmadreza, et al. "Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis." Journal of diabetes and metabolic disorders vol. 20,2 (2021): 1327-1336. doi: https://doi.org/10.1007/s40200-021-00861-9
Mirzaei A, Shahrestanaki E, Daneshzad E, Heshmati J, Djalalinia S, Asayesh H, Mahdavi-Gorabi A, Heshmat R, Qorbani M. Association of hyperglycaemia and periodontitis: an updated systematic review and meta-analysis. J Diabetes Metab Disord. 2021 Aug 11;20(2):1327-1336. doi: 10.1007/s40200-021-00861-9. eCollection 2021 Dec. PMID: 34900784; PMCID: PMC8630338.
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Colchicine Treatment in SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis.

American journal of therapeutics

Beran A, Mhanna M, Wahood W, Ghazaleh S, Sajdeya O, Kalifa M, Ayesh H, Srour O, Mhanna AS, Altorok N, Assaly R.
PMID: 34117141
Am J Ther. 2021 Dec 23;29(1):e95-e98. doi: 10.1097/MJT.0000000000001397.

No abstract available.

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Beran A, Mhanna M, Wahood W, et al. Colchicine Treatment in SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis. Am J Ther. 2021;29(1):e95-e98doi: 10.1097/MJT.0000000000001397.
Beran, A., Mhanna, M., Wahood, W., Ghazaleh, S., Sajdeya, O., Kalifa, M., Ayesh, H., Srour, O., Mhanna, A. S., Altorok, N., & Assaly, R. (2021). Colchicine Treatment in SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis. American journal of therapeutics, 29(1), e95-e98. https://doi.org/10.1097/MJT.0000000000001397
Beran, Azizullah, et al. "Colchicine Treatment in SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis." American journal of therapeutics vol. 29,1 (2021): e95-e98. doi: https://doi.org/10.1097/MJT.0000000000001397
Beran A, Mhanna M, Wahood W, Ghazaleh S, Sajdeya O, Kalifa M, Ayesh H, Srour O, Mhanna AS, Altorok N, Assaly R. Colchicine Treatment in SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis. Am J Ther. 2021 Dec 23;29(1):e95-e98. doi: 10.1097/MJT.0000000000001397. PMID: 34117141.
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Hybrid convergent ablation versus endocardial catheter ablation for atrial fibrillation: A systematic review and meta-analysis.

Journal of arrhythmia

Mhanna M, Beran A, Al-Abdouh A, Ayesh H, Sajdeya O, Srour O, Alsaiqali M, Alhasanat OH, Burmeister C, Abumoawad AM, Chacko P.
PMID: 34887950
J Arrhythm. 2021 Nov 02;37(6):1459-1467. doi: 10.1002/joa3.12653. eCollection 2021 Dec.

INTRODUCTION: Endocardial catheter ablation (ECA) for atrial fibrillation (AF) has limited efficacy. Hybrid convergent procedure (HCP) with both epicardial and endocardial ablation is a novel strategy for AF treatment. In this meta-analysis, we aimed to evaluate the efficacy and...

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Mhanna M, Beran A, Al-Abdouh A, et al. Hybrid convergent ablation versus endocardial catheter ablation for atrial fibrillation: A systematic review and meta-analysis. J Arrhythm. 2021;37(6):1459-1467doi: 10.1002/joa3.12653.
Mhanna, M., Beran, A., Al-Abdouh, A., Ayesh, H., Sajdeya, O., Srour, O., Alsaiqali, M., Alhasanat, O. H., Burmeister, C., Abumoawad, A. M., & Chacko, P. (2021). Hybrid convergent ablation versus endocardial catheter ablation for atrial fibrillation: A systematic review and meta-analysis. Journal of arrhythmia, 37(6), 1459-1467. https://doi.org/10.1002/joa3.12653
Mhanna, Mohammed, et al. "Hybrid convergent ablation versus endocardial catheter ablation for atrial fibrillation: A systematic review and meta-analysis." Journal of arrhythmia vol. 37,6 (2021): 1459-1467. doi: https://doi.org/10.1002/joa3.12653
Mhanna M, Beran A, Al-Abdouh A, Ayesh H, Sajdeya O, Srour O, Alsaiqali M, Alhasanat OH, Burmeister C, Abumoawad AM, Chacko P. Hybrid convergent ablation versus endocardial catheter ablation for atrial fibrillation: A systematic review and meta-analysis. J Arrhythm. 2021 Nov 02;37(6):1459-1467. doi: 10.1002/joa3.12653. eCollection 2021 Dec. PMID: 34887950; PMCID: PMC8637076.
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