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Rice MT, von Borstel A, Chevour P, et al. Recognition of the antigen-presenting molecule MR1 by a Vδ3. Proc Natl Acad Sci U S A. 2021;118(49)doi: 10.1073/pnas.2110288118.
Rice, M. T., von Borstel, A., Chevour, P., Awad, W., Howson, L. J., Littler, D. R., Gherardin, N. A., Le Nours, J., Giles, E. M., Berry, R., Godfrey, D. I., Davey, M. S., Rossjohn, J., & Gully, B. S. (2021). Recognition of the antigen-presenting molecule MR1 by a Vδ3. Proceedings of the National Academy of Sciences of the United States of America, 118(49), . https://doi.org/10.1073/pnas.2110288118
Rice, Michael T, et al. "Recognition of the antigen-presenting molecule MR1 by a Vδ3." Proceedings of the National Academy of Sciences of the United States of America vol. 118,49 (2021). doi: https://doi.org/10.1073/pnas.2110288118
Rice MT, von Borstel A, Chevour P, Awad W, Howson LJ, Littler DR, Gherardin NA, Le Nours J, Giles EM, Berry R, Godfrey DI, Davey MS, Rossjohn J, Gully BS. Recognition of the antigen-presenting molecule MR1 by a Vδ3. Proc Natl Acad Sci U S A. 2021 Dec 07;118(49). doi: 10.1073/pnas.2110288118. PMID: 34845016.
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Proc Natl Acad Sci U S A. 2021 Dec 07;118(49). doi: 10.1073/pnas.2110288118.

Recognition of the antigen-presenting molecule MR1 by a Vδ3.

Proceedings of the National Academy of Sciences of the United States of America

Michael T Rice, Anouk von Borstel, Priyanka Chevour, Wael Awad, Lauren J Howson, Dene R Littler, Nicholas A Gherardin, Jérôme Le Nours, Edward M Giles, Richard Berry, Dale I Godfrey, Martin S Davey, Jamie Rossjohn, Benjamin S Gully

Affiliations

  1. Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
  2. Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
  3. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.
  4. Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.
  5. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC 3010, Australia.
  6. Department of Paediatrics, Monash University, Clayton, VIC 3168, Australia.
  7. Centre for Innate Immunity and Infectious Disease, Hudson Institute of Medicine, Clayton, VIC 3168, Australia.
  8. Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; [email protected] [email protected] [email protected].
  9. Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.

PMID: 34845016 DOI: 10.1073/pnas.2110288118

Abstract

Unlike conventional αβ T cells, γδ T cells typically recognize nonpeptide ligands independently of major histocompatibility complex (MHC) restriction. Accordingly, the γδ T cell receptor (TCR) can potentially recognize a wide array of ligands; however, few ligands have been described to date. While there is a growing appreciation of the molecular bases underpinning variable (V)δ1

Keywords: MR1; structural immunology; γδTCR

Conflict of interest statement

Competing interest statement: J.R. is an inventor on patents describing MR1 tetramers and MR1 ligands.

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