Display options
Cite
Wang SS, Zhong C, Epeldegui M, et al. Host characteristics associated with serologic inflammatory biomarkers in women. Cytokine. 2021;149:155726doi: 10.1016/j.cyto.2021.155726.
Wang, S. S., Zhong, C., Epeldegui, M., Nunes, S., Magpantay, L., DeHart, J. C., Hurley, S., Goldberg, D., Martinez, E., Lacey, J. V., Martinez-Maza, O., & Reynolds, P. (2022). Host characteristics associated with serologic inflammatory biomarkers in women. Cytokine, 149155726. https://doi.org/10.1016/j.cyto.2021.155726
Wang, Sophia S, et al. "Host characteristics associated with serologic inflammatory biomarkers in women." Cytokine vol. 149 (2022): 155726. doi: https://doi.org/10.1016/j.cyto.2021.155726
Wang SS, Zhong C, Epeldegui M, Nunes S, Magpantay L, DeHart JC, Hurley S, Goldberg D, Martinez E, Lacey JV, Martinez-Maza O, Reynolds P. Host characteristics associated with serologic inflammatory biomarkers in women. Cytokine. 2022 Jan;149:155726. doi: 10.1016/j.cyto.2021.155726. Epub 2021 Oct 16. PMID: 34666235; PMCID: PMC8680201.
Copy Download .nbib Format: NLM
Share it on

Cytokine. 2022 Jan;149:155726. doi: 10.1016/j.cyto.2021.155726. Epub 2021 Oct 16.

Host characteristics associated with serologic inflammatory biomarkers in women.

Cytokine

Sophia S Wang, Charlie Zhong, Marta Epeldegui, Sarah Nunes, Larry Magpantay, Jessica Clague DeHart, Susan Hurley, Debbie Goldberg, Elena Martinez, James V Lacey, Otoniel Martinez-Maza, Peggy Reynolds

Affiliations

  1. Division of Health Analytics, City of Hope, Duarte, CA, USA. Electronic address: [email protected].
  2. Eugene and Ruth Roberts Academy, City of Hope, Duarte, CA, USA.
  3. University of California, Los Angeles, CA, USA.
  4. Eugene and Ruth Roberts Academy, City of Hope, Duarte, CA, USA; Chapman University, Orange, CA, USA.
  5. Claremont College, Claremont, CA, USA.
  6. University of California San Francisco, CA, USA; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, CA, USA.
  7. University of California San Francisco, CA, USA.
  8. University of California San Diego, CA, USA.
  9. Division of Health Analytics, City of Hope, Duarte, CA, USA.

PMID: 34666235 PMCID: PMC8680201 DOI: 10.1016/j.cyto.2021.155726

Abstract

BACKGROUND: There is growing evidence that exposure to low-grade inflammation may be associated with adverse health outcomes.

METHODS: We conducted a cross-sectional study within the California Teachers Study prospective cohort, among female participants who had completed a questionnaire that asked about their health behaviors (e.g., diabetes, physical activity, body mass index, medication use) and who had donated blood within a year of their questionnaire. 822 women with stored serum were evaluated for 16 immune biomarkers. In addition, four immune pathways were constructed: Th1, pro-inflammatory/macrophage activation, B-cell activation, and T-cell activation. Odds ratios (ORs) and 95% confidence intervals (CI) for the association between host characteristics and immune biomarkers were assessed using logistic regression models.

RESULT: Compared to women of a normal BMI, obese women (>30 kg/m

CONCLUSIONS: Several host characteristics were associated with circulating levels of immune biomarkers, including markers of inflammation. Further understanding of associations between immune marker profiles with human disease are warranted.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Blood; Circulating markers; Cross-sectional; Diabetes; Epidemiology; Human; Inflammation; Obesity; Physical activity; Statins

References

  1. Eur J Appl Physiol. 2014 Aug;114(8):1737-48 - PubMed
  2. J Obes. 2020 Jan 30;2020:5076858 - PubMed
  3. J Am Coll Cardiol. 2009 Dec 1;54(23):2129-38 - PubMed
  4. Endocr Relat Cancer. 2010 Oct 29;17(4):1007-19 - PubMed
  5. Lancet. 2001 Feb 17;357(9255):539-45 - PubMed
  6. Clin Biochem. 2013 Oct;46(15):1353-71 - PubMed
  7. Nature. 2002 Dec 19-26;420(6917):860-7 - PubMed
  8. Cytokine. 2012 Jan;57(1):136-42 - PubMed
  9. Diabetes. 2003 Jul;52(7):1799-805 - PubMed
  10. Cytokine. 2016 Oct;86:100-109 - PubMed
  11. Cancer Causes Control. 2010 Aug;21(8):1323-33 - PubMed
  12. Cancer Causes Control. 2002 Sep;13(7):625-35 - PubMed
  13. PeerJ. 2015 Feb 05;3:e764 - PubMed
  14. Gerontology. 2009;55(4):379-86 - PubMed
  15. PLoS One. 2015 Mar 17;10(3):e0121971 - PubMed
  16. Cancer Res. 2012 Sep 15;72(18):4733-43 - PubMed
  17. Nature. 2004 Sep 23;431(7007):405-6 - PubMed
  18. Cytokine. 2016 Sep;85:71-9 - PubMed
  19. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  20. Front Physiol. 2020 Jan 29;10:1607 - PubMed
  21. Cancer Epidemiol Biomarkers Prev. 2011 May;20(5):799-810 - PubMed
  22. Surg Obes Relat Dis. 2010 Sep-Oct;6(5):538-41 - PubMed
  23. Front Biosci (Elite Ed). 2013 Jan 01;5:461-78 - PubMed
  24. Annu Rev Immunol. 2011;29:415-45 - PubMed
  25. Clin Transl Med. 2014 Jun 14;3:14 - PubMed
  26. Health Psychol. 2019 Oct;38(10):866-877 - PubMed
  27. EBioMedicine. 2020 Nov;61:103062 - PubMed
  28. Clin Endocrinol (Oxf). 2013 Feb;78(2):232-41 - PubMed
  29. Circulation. 2000 Apr 18;101(15):1767-72 - PubMed
  30. Cancer Epidemiol Biomarkers Prev. 2014 Feb;23(2):343-9 - PubMed
  31. Clin Cancer Res. 2016 Jan 15;22(2):328-36 - PubMed
  32. Age (Dordr). 2011 Jun;33(2):209-17 - PubMed
  33. Int J Cancer. 2018 Apr 1;142(7):1332-1342 - PubMed
  34. Cytokine. 2011 Dec;56(3):769-78 - PubMed
  35. Cytokine. 2007 Nov;40(2):75-81 - PubMed
  36. Cell. 2010 Mar 19;140(6):883-99 - PubMed
  37. Afr Health Sci. 2013 Dec;13(4):857-63 - PubMed
  38. Am J Epidemiol. 2013 Apr 15;177(8):787-99 - PubMed
  39. Endocr Metab Immune Disord Drug Targets. 2018;18(3):260-267 - PubMed
  40. JAMA. 1999 Dec 8;282(22):2131-5 - PubMed
  41. Diabetes. 2003 Mar;52(3):812-7 - PubMed

Publication Types

Grant support