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Matory AL, Alkhachroum A, Chiu WT, et al. Electrocerebral Signature of Cardiac Death. Neurocrit Care. 2021;35(3):853-861doi: 10.1007/s12028-021-01233-0.
Matory, A. L., Alkhachroum, A., Chiu, W. T., Eliseyev, A., Doyle, K., Rohaut, B., Egbebike, J. A., Velazquez, A. G., Der-Nigoghossian, C., Paniker, L., Prager, K. M., Agarwal, S., Roh, D., Park, S., & Claassen, J. (2021). Electrocerebral Signature of Cardiac Death. Neurocritical care, 35(3), 853-861. https://doi.org/10.1007/s12028-021-01233-0
Matory, Adu L, et al. "Electrocerebral Signature of Cardiac Death." Neurocritical care vol. 35,3 (2021): 853-861. doi: https://doi.org/10.1007/s12028-021-01233-0
Matory AL, Alkhachroum A, Chiu WT, Eliseyev A, Doyle K, Rohaut B, Egbebike JA, Velazquez AG, Der-Nigoghossian C, Paniker L, Prager KM, Agarwal S, Roh D, Park S, Claassen J. Electrocerebral Signature of Cardiac Death. Neurocrit Care. 2021 Dec;35(3):853-861. doi: 10.1007/s12028-021-01233-0. Epub 2021 Jun 28. PMID: 34184175.
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Neurocrit Care. 2021 Dec;35(3):853-861. doi: 10.1007/s12028-021-01233-0. Epub 2021 Jun 28.

Electrocerebral Signature of Cardiac Death.

Neurocritical care

Adu L Matory, Ayham Alkhachroum, Wei-Ting Chiu, Andrey Eliseyev, Kevin Doyle, Benjamin Rohaut, Jennifer A Egbebike, Angela G Velazquez, Caroline Der-Nigoghossian, Lucy Paniker, Kenneth M Prager, Sachin Agarwal, David Roh, Soojin Park, Jan Claassen

Affiliations

  1. Department of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
  2. Bernstein Center for Computational Neuroscience, Berlin, Germany.
  3. Department of Neurology, University of Miami, Miami, FL, USA.
  4. Department of Neurology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
  5. Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
  6. Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan.
  7. Division of Critical Care Medicine, Department of Emergency and Critical Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
  8. Brain institute - ICM, Inserm U1127, CNRS UMR 7225, Sorbonne Université, Paris, France.
  9. Department of Neurology, Neuro-ICU, Groupe Hospitalier Universitaire APHP, Pitié-Salpêtrière, Sorbonne Université, Paris, France.
  10. Sorbonne Université, Paris, France.
  11. Pharmacy, Columbia University Irving Medical Center, New York, NY, USA.
  12. Clinical Ethics, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
  13. Department of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA. [email protected].

PMID: 34184175 DOI: 10.1007/s12028-021-01233-0

Abstract

BACKGROUND: Electroencephalography (EEG) findings following cardiovascular collapse in death are uncertain. We aimed to characterize EEG changes immediately preceding and following cardiac death.

METHODS: We retrospectively analyzed EEGs of patients who died from cardiac arrest while undergoing standard EEG monitoring in an intensive care unit. Patients with brain death preceding cardiac death were excluded. Three events during fatal cardiovascular failure were investigated: (1) last recorded QRS complex on electrocardiogram (QRS

RESULTS: Among 19 patients who died while undergoing EEG monitoring, seven (37%) had a comfort-measures-only status and 18 (95%) had a do-not-resuscitate status in place at the time of death. EEG

CONCLUSIONS: Rarely may patients have transient electrocerebral activity following the last recorded QRS (less than 5 min) and estimated cessation of cerebral blood flow. These results may have implications for discussions around cardiopulmonary resuscitation and organ donation.

© 2021. Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society.

Keywords: Brain hypoxia; Cardiac arrest; Consciousness; Death; Encephalography; Hypotension

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