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Potapov I, Kanneganti TD, Del Sol A. Fostering experimental and computational synergy to modulate hyperinflammation. Trends Immunol. 2021;43(1):4-7doi: 10.1016/j.it.2021.11.004.
Potapov, I., Kanneganti, T. D., & Del Sol, A. (2022). Fostering experimental and computational synergy to modulate hyperinflammation. Trends in immunology, 43(1), 4-7. https://doi.org/10.1016/j.it.2021.11.004
Potapov, Ilya, et al. "Fostering experimental and computational synergy to modulate hyperinflammation." Trends in immunology vol. 43,1 (2022): 4-7. doi: https://doi.org/10.1016/j.it.2021.11.004
Potapov I, Kanneganti TD, Del Sol A. Fostering experimental and computational synergy to modulate hyperinflammation. Trends Immunol. 2022 Jan;43(1):4-7. doi: 10.1016/j.it.2021.11.004. Epub 2021 Nov 26. PMID: 34844849.
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Trends Immunol. 2022 Jan;43(1):4-7. doi: 10.1016/j.it.2021.11.004. Epub 2021 Nov 26.

Fostering experimental and computational synergy to modulate hyperinflammation.

Trends in immunology

Ilya Potapov, Thirumala-Devi Kanneganti, Antonio Del Sol

Affiliations

  1. Computational Biology Group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4362 Esch-sur-Alzette, Luxembourg.
  2. Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  3. Computational Biology Group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4362 Esch-sur-Alzette, Luxembourg; Computational Biology Group, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Bizkaia Technology Park, Derio 48160, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao 48013, Spain. Electronic address: [email protected].

PMID: 34844849 DOI: 10.1016/j.it.2021.11.004

Abstract

The molecular underpinnings of the uncontrolled release of proinflammatory cytokines and chemokines ('cytokine storm'), which can cause organ damage and even mortality, are not completely understood. Furthermore, targeted therapeutic options to dampen such hyperinflammation are scarce. Here, we highlight the ways in which technological advances have set the stage for a new age of synergy between experimental and computational researchers to guide the discovery of novel therapeutic targets for modulating hyperinflammation.

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Conflict of interest statement

Declaration of interests No interests are declared.

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