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Cancer Cell. 2021 Dec 13;39(12):1549-1552. doi: 10.1016/j.ccell.2021.11.010.

Toward a better understanding of T cells in cancer.

Cancer cell

David Y Oh, Lawrence Fong, Evan W Newell, Mary Jo Turk, Hongbo Chi, Howard Y Chang, Ansuman T Satpathy, Benjamin Fairfax, Bruno Silva-Santos, Olivier Lantz

PMID: 34906313 DOI: 10.1016/j.ccell.2021.11.010

Abstract

T cells mediate anti-tumor immune responses and are the key target of immune checkpoint therapy, but they can also promote immune tolerance. A clear understanding of the specific contributions and biology of different T cell subsets is required to fully harness the curative potential of immunotherapies. Experts discuss the state of the field and key challenges for moving forward.

Copyright © 2021 Elsevier Inc. All rights reserved.

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