Display options
Cite
Kim HS, Kim HY. Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2. Cytokine. 2021;150:155754doi: 10.1016/j.cyto.2021.155754.
Kim, H. S., & Kim, H. Y. (2021). Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2. Cytokine, 150155754. https://doi.org/10.1016/j.cyto.2021.155754
Kim, Hee Sun, and Kim, Hye Young. "Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2." Cytokine vol. 150 (2021): 155754. doi: https://doi.org/10.1016/j.cyto.2021.155754
Kim HS, Kim HY. Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2. Cytokine. 2021 Nov 20;150:155754. doi: 10.1016/j.cyto.2021.155754. Epub 2021 Nov 20. PMID: 34808537.
Copy Download .nbib Format: NLM
Share it on

Cytokine. 2021 Nov 20;150:155754. doi: 10.1016/j.cyto.2021.155754. Epub 2021 Nov 20.

Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2.

Cytokine

Hee Sun Kim, Hye Young Kim

Affiliations

  1. Department of Microbiology College of Medicine, Yeungnam University, Daegu, Republic of Korea. Electronic address: [email protected].
  2. Department of Microbiology College of Medicine, Yeungnam University, Daegu, Republic of Korea.

PMID: 34808537 DOI: 10.1016/j.cyto.2021.155754

Abstract

Extracellular sulfatases (sulfatase 1 and sulfatase 2) mediate up- or down-regulatory effects of cytokines on angiotensin II (Ang II)-induced expression of hypertensive mediators in hypertensive cells. The overproduction of transforming growth factor-β1 (TGF-β1) is associated with chronic hypertension. In this study, we examined the role of extracellular sulfatases on TGF-β1-induced effects associated with the expression of mediators related to hypertension in vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR). First, TGF-β1 increased the expression of 12-lipoxygenase (12-LO) and endothelin-1 (ET-1), inhibited dimethylarginine dimethylaminohydrolase-1 (DDAH-1) expression and showed additive effects on Ang II-induced 12-LO and ET-1 expression as well as Ang II-induced inhibition of DDAH-1 expression in SHR VSMCs. However, it had no effect on the expression of 12-LO, ET-1, and DDAH-1 in VSMCs from normotensive Wistar Kyoto rats. Downregulation of sulfatase 2 (Sulf2) inhibited all of these hypertensive effects caused by TGF-β1, while sulfatase 1 (Sulf1) had no effect on these events in SHR VSMCs. All these hypertensive effects of TGF-β1 were dependent on the Ang II subtype 1 receptor (AT

Copyright © 2021. Published by Elsevier Ltd.

Keywords: Ang II subtype 1 receptor; Hypertension; Sulfatase 1; Sulfatase 2; TGF-β1; Vascular smooth muscle cells

Publication Types