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Yano Y, Abnet CC, Poustchi H, et al. Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study from a High-risk Region: Golestan Cohort Study. Cancer Prev Res (Phila). 2021;14(7):709-718doi: 10.1158/1940-6207.CAPR-20-0577.
Yano, Y., Abnet, C. C., Poustchi, H., Roshandel, G., Pourshams, A., Islami, F., Khoshnia, M., Amiriani, T., Norouzi, A., Kamangar, F., Boffetta, P., Brennan, P., Dawsey, S. M., Vogtmann, E., Malekzadeh, R., & Etemadi, A. (2021). Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study from a High-risk Region: Golestan Cohort Study. Cancer prevention research (Philadelphia, Pa.), 14(7), 709-718. https://doi.org/10.1158/1940-6207.CAPR-20-0577
Yano, Yukiko, et al. "Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study from a High-risk Region: Golestan Cohort Study." Cancer prevention research (Philadelphia, Pa.) vol. 14,7 (2021): 709-718. doi: https://doi.org/10.1158/1940-6207.CAPR-20-0577
Yano Y, Abnet CC, Poustchi H, Roshandel G, Pourshams A, Islami F, Khoshnia M, Amiriani T, Norouzi A, Kamangar F, Boffetta P, Brennan P, Dawsey SM, Vogtmann E, Malekzadeh R, Etemadi A. Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study from a High-risk Region: Golestan Cohort Study. Cancer Prev Res (Phila). 2021 Jul;14(7):709-718. doi: 10.1158/1940-6207.CAPR-20-0577. Epub 2021 Mar 17. PMID: 33731409; PMCID: PMC8295188.
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Cancer Prev Res (Phila). 2021 Jul;14(7):709-718. doi: 10.1158/1940-6207.CAPR-20-0577. Epub 2021 Mar 17.

Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study from a High-risk Region: Golestan Cohort Study.

Cancer prevention research (Philadelphia, Pa.)

Yukiko Yano, Christian C Abnet, Hossein Poustchi, Gholamreza Roshandel, Akram Pourshams, Farhad Islami, Masoud Khoshnia, Taghi Amiriani, Alireza Norouzi, Farin Kamangar, Paolo Boffetta, Paul Brennan, Sanford M Dawsey, Emily Vogtmann, Reza Malekzadeh, Arash Etemadi

Affiliations

  1. Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland. [email protected] [email protected].
  2. Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
  3. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  4. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  5. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
  6. Data Science Program, American Cancer Society, Atlanta, Georgia.
  7. Department of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, Maryland.
  8. Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York.
  9. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  10. Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France.

PMID: 33731409 PMCID: PMC8295188 DOI: 10.1158/1940-6207.CAPR-20-0577

Abstract

Tooth loss and periodontal disease have been associated with several cancers, and poor oral health may be an important risk factor for upper gastrointestinal (UGI, i.e., esophageal and gastric) cancers. We assessed the relationship between oral health and UGI cancers using a large prospective study of over 50,000 adults living in Golestan Province, Iran, a high-incidence area for these cancers. Hazard ratios (HRs) and 95% confidence intervals (CI) were estimated for the association between three different measures of oral health [frequency of tooth brushing; number of missing teeth; and the sum of decayed, missing, and filled teeth (DMFT)] and UGI cancers. During a median follow-up duration of 13 years, there were 794 incident UGI cancers (396 esophageal and 398 gastric cancers). Daily tooth brushing was associated with a decreased risk of developing both esophageal (HR = 0.670; 95% CI: 0.486-0.924) and gastric (HR = 0.741; 95% CI: 0.544-1.01) cancers (combined UGI cancer HR = 0.697; 95% CI: 0.558-0.871) compared with never brushing. Tooth loss in excess of the loess smoothed, age- and sex-specific median number of teeth lost was significantly associated with esophageal (HR = 1.64; 95% CI: 1.08-2.47) and gastric cancers (HR = 1.58; 95% CI: 1.05-2.38). There were some adverse associations between DMFT and UGI cancers but most were not statistically significant. These results suggest increased risk of developing UGI cancers among individuals with poor oral health, and those who do not perform regular oral hygiene. PREVENTION RELEVANCE: Poor oral health is associated with the risk of upper gastrointestinal cancers, and oral hygiene practices may help prevent these cancers.

©2021 American Association for Cancer Research.

References

  1. Lancet Gastroenterol Hepatol. 2020 Jan;5(1):42-54 - PubMed
  2. J Natl Cancer Inst. 2001 Feb 7;93(3):226-33 - PubMed
  3. Gastroenterology. 2019 Apr;156(5):1416-1427 - PubMed
  4. Crit Rev Toxicol. 1996;26(2):149-61 - PubMed
  5. Int J Epidemiol. 2017 Dec 1;46(6):2028-2035 - PubMed
  6. Oral Oncol. 2013 Oct;49(10):1010-7 - PubMed
  7. Cancer Lett. 1995 Jun 29;93(1):17-48 - PubMed
  8. Br J Cancer. 2012 Aug 21;107(5):888-94 - PubMed
  9. Cancer Causes Control. 2001 Nov;12(9):847-54 - PubMed
  10. J Natl Cancer Inst. 2003 Sep 17;95(18):1404-13 - PubMed
  11. Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3062-8 - PubMed
  12. Br J Cancer. 2005 Jan 17;92(1):176-81 - PubMed
  13. Periodontol 2000. 2020 Jun;83(1):213-233 - PubMed
  14. United European Gastroenterol J. 2019 Nov;7(9):1241-1249 - PubMed
  15. Cancer Prev Res (Phila). 2013 May;6(5):477-82 - PubMed
  16. Periodontol 2000. 2011 Feb;55(1):9-15 - PubMed
  17. PLoS One. 2010 Jun 17;5(6):e11183 - PubMed
  18. Eur J Cancer. 2009 Dec;45(18):3156-65 - PubMed
  19. Gastroenterology. 2018 Jan;154(2):360-373 - PubMed
  20. Thorac Cancer. 2019 Apr;10(4):966-974 - PubMed
  21. Br J Cancer. 2004 Apr 5;90(7):1402-6 - PubMed
  22. Int J Cancer. 2017 Feb 1;140(3):646-652 - PubMed
  23. Middle East J Dig Dis. 2016 Oct;8(4):249-266 - PubMed
  24. Arch Iran Med. 2007 Jan;10(1):70-82 - PubMed
  25. Scand J Gastroenterol. 2005 Jun;40(6):681-7 - PubMed
  26. Cancer Causes Control. 2008 Nov;19(9):895-907 - PubMed
  27. Environ Sci Pollut Res Int. 2016 Mar;23(6):5077-98 - PubMed
  28. Int J Cancer. 2018 Jun 1;142(11):2244-2253 - PubMed
  29. Cancer Res. 2015 Nov 15;75(22):4876-83 - PubMed
  30. Int J Cancer. 2018 Nov 1;143(9):2281-2288 - PubMed
  31. Int J Epidemiol. 2010 Feb;39(1):52-9 - PubMed
  32. Infect Agent Cancer. 2016 Jan 19;11:3 - PubMed
  33. Am J Epidemiol. 2007 Nov 15;166(10):1159-73 - PubMed
  34. Lancet Oncol. 2008 Jun;9(6):550-8 - PubMed
  35. Periodontol 2000. 2016 Oct;72(1):142-52 - PubMed
  36. Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):1068-70 - PubMed
  37. Int J Epidemiol. 2005 Apr;34(2):467-74 - PubMed
  38. BMJ. 2012 Apr 17;344:e2502 - PubMed
  39. Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1222-7 - PubMed
  40. Microorganisms. 2019 Jan 13;7(1): - PubMed
  41. Cancer Causes Control. 2012 Mar;23(3):399-404 - PubMed
  42. CA Cancer J Clin. 2018 Nov;68(6):394-424 - PubMed
  43. Epidemiol Rev. 2017 Jan 1;39(1):49-58 - PubMed
  44. BMC Oral Health. 2007 Jul 17;7:10 - PubMed
  45. Br J Cancer. 2018 Feb 6;118(3):428-434 - PubMed
  46. Int J Epidemiol. 2009 Aug;38(4):978-88 - PubMed
  47. J Clin Periodontol. 2020 Jul;47(7):796-808 - PubMed
  48. Int J Cancer. 2020 Jan 1;146(1):18-25 - PubMed
  49. Sci Rep. 2015 Oct 14;5:15203 - PubMed
  50. Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):337-347 - PubMed

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