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Cappon D, den Boer T, Jordan C, et al. Transcranial magnetic stimulation (TMS) for geriatric depression. Ageing Res Rev. 2021;74:101531doi: 10.1016/j.arr.2021.101531.
Cappon, D., den Boer, T., Jordan, C., Yu, W., Metzger, E., & Pascual-Leone, A. (2021). Transcranial magnetic stimulation (TMS) for geriatric depression. Ageing research reviews, 74101531. https://doi.org/10.1016/j.arr.2021.101531
Cappon, Davide, et al. "Transcranial magnetic stimulation (TMS) for geriatric depression." Ageing research reviews vol. 74 (2021): 101531. doi: https://doi.org/10.1016/j.arr.2021.101531
Cappon D, den Boer T, Jordan C, Yu W, Metzger E, Pascual-Leone A. Transcranial magnetic stimulation (TMS) for geriatric depression. Ageing Res Rev. 2021 Nov 25;74:101531. doi: 10.1016/j.arr.2021.101531. Epub 2021 Nov 25. PMID: 34839043.
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Ageing Res Rev. 2021 Nov 25;74:101531. doi: 10.1016/j.arr.2021.101531. Epub 2021 Nov 25.

Transcranial magnetic stimulation (TMS) for geriatric depression.

Ageing research reviews

Davide Cappon, Tim den Boer, Caleb Jordan, Wanting Yu, Eran Metzger, Alvaro Pascual-Leone

Affiliations

  1. Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
  2. Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
  3. Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA, USA.
  4. Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
  5. Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA; Guttmann Brain Health Institut, Guttmann Institut, Spain.

PMID: 34839043 DOI: 10.1016/j.arr.2021.101531

Abstract

BACKGROUND: The prevalence of treatment-resistant geriatric depression (GD) highlights the need for treatments that preserve cognitive functions and recognize polypharmacy in elderly, yet effectively reduce symptom burden. Transcranial magnetic stimulation (TMS) is a proven intervention for treatment-resistant depression in younger adults but the efficacy of TMS to treat depressed older adults is still unclear. This review provides an updated view on the efficacy of TMS treatment for GD, discusses methodological differences between trials in TMS application, and explores avenues for optimization of TMS treatment in the context of the ageing brain.

METHODS: A systematic review was conducted to identify published literature on the antidepressant efficacy of TMS for GD. Databases PubMed, Embase, and PsycINFO were searched for English language articles in peer-reviewed journals in March 2021.

RESULTS: Seven randomized controlled trials (RCTs) (total n = 260, active n = 148, control n = 112) and seven uncontrolled trials (total n = 160) were included. Overall, we found substantial variability in the clinical response, ranging from 6.7% to 54.3%.

CONCLUSIONS: The reviewed literature highlights large heterogeneity among studies both in terms of the employed TMS dosage and the observed clinical efficacy. This highlights the need for optimizing TMS dosage by recognizing the unique clinical features of GD. We showcase a set of novel approaches for the optimization of the TMS protocol for depression and discuss the possibility for a standardized TMS protocol tailored for the treatment of GD.

Copyright © 2021. Published by Elsevier B.V.

Keywords: Geriatric depression (GD); Non-invasive brain stimulation; Nonpharmacological intervention; Polypharmacy; Transcranial magnetic stimulation (TMS)

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