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Shen JD, Chen SJ, Chen HY, et al. Review of Animal Models to Study Urinary Bladder Function. Biology (Basel). 2021;10(12)doi: 10.3390/biology10121316.
Shen, J. D., Chen, S. J., Chen, H. Y., Chiu, K. Y., Chen, Y. H., & Chen, W. C. (2021). Review of Animal Models to Study Urinary Bladder Function. Biology, 10(12), . https://doi.org/10.3390/biology10121316
Shen, Jing-Dung, et al. "Review of Animal Models to Study Urinary Bladder Function." Biology vol. 10,12 (2021). doi: https://doi.org/10.3390/biology10121316
Shen JD, Chen SJ, Chen HY, Chiu KY, Chen YH, Chen WC. Review of Animal Models to Study Urinary Bladder Function. Biology (Basel). 2021 Dec 11;10(12). doi: 10.3390/biology10121316. PMID: 34943231.
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Biology (Basel). 2021 Dec 11;10(12). doi: 10.3390/biology10121316.

Review of Animal Models to Study Urinary Bladder Function.

Biology

Jing-Dung Shen, Szu-Ju Chen, Huey-Yi Chen, Kun-Yuan Chiu, Yung-Hsiang Chen, Wen-Chi Chen

Affiliations

  1. Division of Urology, Department of Surgery, Taichung Armed Forces General Hospital, Taichung 41168, Taiwan.
  2. National Defense Medical Center, Taipei 11490, Taiwan.
  3. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
  4. Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
  5. Department of Obstetrics and Gynecology, Department of Medical Research, Department of Urology, China Medical University Hospital, Taichung 40447, Taiwan.
  6. Department of Psychology, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.

PMID: 34943231 DOI: 10.3390/biology10121316

Abstract

The urinary bladder (UB) serves as a storage and elimination organ for urine. UB dysfunction can cause multiple symptoms of failure to store urine or empty the bladder, e.g., incontinence, frequent urination, and urinary retention. Treatment of these symptoms requires knowledge on bladder function, which involves physiology, pathology, and even psychology. There is no ideal animal model for the study of UB function to understand and treat associated disorders, as the complexity in humans differs from that of other species. However, several animal models are available to study a variety of other bladder disorders. Such models include animals from rodents to nonhuman primates, such as mice, rats, rabbits, felines, canines, pigs, and mini pigs. For incontinence, vaginal distention might mimic birth trauma and can be measured based on leak point pressure. Using peripheral and central models, inflammation, bladder outlet obstruction, and genetic models facilitated the study of overactive bladder. However, the larger the animal model, the more difficult the study is, due to the associated animal ethics issues, laboratory facility, and budget. This review aims at facilitating adapted animal models to study bladder function according to facility, priority, and disease.

Keywords: animal model; incontinence; interstitial cystitis; overactive bladder; urinary bladder

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