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Wesołowska A, Winiarska H, Owoc J, et al. Effects of Low-Dose Atorvastatin on the Peripheral Blood Mononuclear Cell Secretion of Angiogenic Factors in Type 2 Diabetes. Biomolecules. 2021;11(12)doi: 10.3390/biom11121885.
Wesołowska, A., Winiarska, H., Owoc, J., Borowska, M., Domagała, J., Mikołajczak, P. �. �., Iskakova, S., Dworacki, G., & Dworacka, M. (2021). Effects of Low-Dose Atorvastatin on the Peripheral Blood Mononuclear Cell Secretion of Angiogenic Factors in Type 2 Diabetes. Biomolecules, 11(12), . https://doi.org/10.3390/biom11121885
Wesołowska, Anna, et al. "Effects of Low-Dose Atorvastatin on the Peripheral Blood Mononuclear Cell Secretion of Angiogenic Factors in Type 2 Diabetes." Biomolecules vol. 11,12 (2021). doi: https://doi.org/10.3390/biom11121885
Wesołowska A, Winiarska H, Owoc J, Borowska M, Domagała J, Mikołajczak PŁ, Iskakova S, Dworacki G, Dworacka M. Effects of Low-Dose Atorvastatin on the Peripheral Blood Mononuclear Cell Secretion of Angiogenic Factors in Type 2 Diabetes. Biomolecules. 2021 Dec 15;11(12). doi: 10.3390/biom11121885. PMID: 34944529; PMCID: PMC8699049.
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Biomolecules. 2021 Dec 15;11(12). doi: 10.3390/biom11121885.

Effects of Low-Dose Atorvastatin on the Peripheral Blood Mononuclear Cell Secretion of Angiogenic Factors in Type 2 Diabetes.

Biomolecules

Anna Wesołowska, Hanna Winiarska, Jakub Owoc, Magdalena Borowska, Joanna Domagała, Przemysław Łukasz Mikołajczak, Saule Iskakova, Grzegorz Dworacki, Marzena Dworacka

Affiliations

  1. Department of Pharmacology, Poznan University of Medical Sciences, 60-805 Poznan, Poland.
  2. Department of Clinical Immunology, Poznan University of Medical Sciences, 60-805 Poznan, Poland.
  3. Department of Pharmacology, Asfendiyarov Kazakh National Medical University, Tole Bi Str. 94, Almaty 050000, Kazakhstan.

PMID: 34944529 PMCID: PMC8699049 DOI: 10.3390/biom11121885

Abstract

The aim of this study was to investigate the influence of statins on the secretion of angiogenesis mediators by the peripheral blood mononuclear cells (PBMCs) derived from patients suffering from type 2 diabetes. The study group comprised 30 participants and included: 10 statin-treated patients with diabetes, 10 statin-free diabetic subjects, and 10 statin-free non-diabetic individuals. PBMCs isolated from the blood were cultured in vitro in standard conditions and in an environment mimicking hyperglycemia. Culture supernatants were evaluated for VEGF, MCP-1, Il-10, and Il-12 by flow cytometry using commercial BD

Keywords: angiogenic factors; diabetes; hyperglycemia; peripheral blood mononuclear cells; statins

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