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Zhang Y, Lu Y, Wang S, et al. Excessive Vitamin A Supplementation Increased the Incidence of Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis. Nutrients. 2021;13(12)doi: 10.3390/nu13124251.
Zhang, Y., Lu, Y., Wang, S., Yang, L., Xia, H., & Sun, G. (2021). Excessive Vitamin A Supplementation Increased the Incidence of Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis. Nutrients, 13(12), . https://doi.org/10.3390/nu13124251
Zhang, Yihan, et al. "Excessive Vitamin A Supplementation Increased the Incidence of Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis." Nutrients vol. 13,12 (2021). doi: https://doi.org/10.3390/nu13124251
Zhang Y, Lu Y, Wang S, Yang L, Xia H, Sun G. Excessive Vitamin A Supplementation Increased the Incidence of Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis. Nutrients. 2021 Nov 26;13(12). doi: 10.3390/nu13124251. PMID: 34959803; PMCID: PMC8706818.
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Nutrients. 2021 Nov 26;13(12). doi: 10.3390/nu13124251.

Excessive Vitamin A Supplementation Increased the Incidence of Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis.

Nutrients

Yihan Zhang, Yifei Lu, Shaokang Wang, Ligang Yang, Hui Xia, Guiju Sun

Affiliations

  1. Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

PMID: 34959803 PMCID: PMC8706818 DOI: 10.3390/nu13124251

Abstract

(1) Background: vitamin A deficiency (VAD) is highly prevalent in children living in poor conditions. It has been suggested that vitamin A supplementation (VAS) may reduce the risk of acute respiratory tract infections (ARTI). Our study provides updates on the effects of oral VAS (alone) in children on ARTI and further explores the effect on interesting subgroups. (2) Methods: eight databases were systematically searched from their inception until 5 July 2021. The assessments of inclusion criteria, extraction of data, and data synthesis were carried out independently by two reviewers. (3) Results: a total of 26 randomized trials involving 50,944 participants fulfilled the inclusion criteria. There was no significant association of VAS with the incidence of ARTI compared with the placebo (RR 1.03, 95% CI 0.92 to 1.15). Subgroup analyses showed that VAS higher than WHO recommendations increased the incidence of ARTI by 13% (RR 1.13, 95% CI 1.07 to 1.20), and in the high-dose intervention group, the incidence rate among well-nourished children rose by 66% (RR 1.66, 95% CI 1.30 to 2.11). (4) Conclusions: no more beneficial effects were seen with VAS in children in the prevention or recovery of acute respiratory infections. Excessive VAS may increase the incidence of ARTI in children with normal nutritional status.

Keywords: acute respiratory tract infections; meta-analysis; subgroups; vitamin A supplementation

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