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Testa G, Mora-Maltas B, Camacho-Barcia L, et al. Transdiagnostic Perspective of Impulsivity and Compulsivity in Obesity: From Cognitive Profile to Self-Reported Dimensions in Clinical Samples with and without Diabetes. Nutrients. 2021;13(12)doi: 10.3390/nu13124426.
Testa, G., Mora-Maltas, B., Camacho-Barcia, L., Granero, R., Lucas, I., Agüera, Z., Jiménez-Murcia, S., Baños, R., Bertaina-Anglade, V., Botella, C., Bulló, M., Casanueva, F. F., Dalsgaard, S., Fernández-Real, J. M., Franke, B., Frühbeck, G., Fitó, M., Gómez-Martínez, C., Pintó, X., Poelmans, G., Tinahones, F. J., Torre, R., Salas-Salvadó, J., Serra-Majem, L., Vos, S., Wimberley, T., & Fernández-Aranda, F. (2021). Transdiagnostic Perspective of Impulsivity and Compulsivity in Obesity: From Cognitive Profile to Self-Reported Dimensions in Clinical Samples with and without Diabetes. Nutrients, 13(12), . https://doi.org/10.3390/nu13124426
Testa, Giulia, et al. "Transdiagnostic Perspective of Impulsivity and Compulsivity in Obesity: From Cognitive Profile to Self-Reported Dimensions in Clinical Samples with and without Diabetes." Nutrients vol. 13,12 (2021). doi: https://doi.org/10.3390/nu13124426
Testa G, Mora-Maltas B, Camacho-Barcia L, Granero R, Lucas I, Agüera Z, Jiménez-Murcia S, Baños R, Bertaina-Anglade V, Botella C, Bulló M, Casanueva FF, Dalsgaard S, Fernández-Real JM, Franke B, Frühbeck G, Fitó M, Gómez-Martínez C, Pintó X, Poelmans G, Tinahones FJ, Torre R, Salas-Salvadó J, Serra-Majem L, Vos S, Wimberley T, Fernández-Aranda F. Transdiagnostic Perspective of Impulsivity and Compulsivity in Obesity: From Cognitive Profile to Self-Reported Dimensions in Clinical Samples with and without Diabetes. Nutrients. 2021 Dec 10;13(12). doi: 10.3390/nu13124426. PMID: 34959979; PMCID: PMC8707121.
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Nutrients. 2021 Dec 10;13(12). doi: 10.3390/nu13124426.

Transdiagnostic Perspective of Impulsivity and Compulsivity in Obesity: From Cognitive Profile to Self-Reported Dimensions in Clinical Samples with and without Diabetes.

Nutrients

Giulia Testa, Bernat Mora-Maltas, Lucía Camacho-Barcia, Roser Granero, Ignacio Lucas, Zaida Agüera, Susana Jiménez-Murcia, Rosa Baños, Valerie Bertaina-Anglade, Cristina Botella, Mònica Bulló, Felipe F Casanueva, Søren Dalsgaard, José-Manuel Fernández-Real, Barbara Franke, Gema Frühbeck, Montserrat Fitó, Carlos Gómez-Martínez, Xavier Pintó, Geert Poelmans, Francisco J Tinahones, Rafael de la Torre, Jordi Salas-Salvadó, Lluis Serra-Majem, Stephanie Vos, Theresa Wimberley, Fernando Fernández-Aranda

Affiliations

  1. Department of Psychiatry, University Hospital of Bellvitge, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
  2. Psychiatry and Mental Health Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
  3. Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
  4. Department of Psychobiology and Methodology, Autonomous University of Barcelona, 08193 Barcelona, Spain.
  5. Department of Public Health, Mental Health and Perinatal Nursing, School of Nursing, University of Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
  6. Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
  7. Instituto Polibienestar, Universitat de Valencia, 46010 Valencia, Spain.
  8. Core Lab Department, Biotrial Neurosciences, 35000 Rennes, France.
  9. Department of Basic Psychology Clinic and Psychobiology, Universitat Jaume I, Castellón de la Plana, 12071 Castellón, Spain.
  10. Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Rovira i Virgili (URV), 43201 Reus, Spain.
  11. Institut d'Investigació Sanitaria Pere Virgili (IISPV), Hospital Universitari de Sant Joan de Reus, 43204 Reus, Spain.
  12. Molecular and Cellular Endocrinology Group, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago de Compostela University (USC) and Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad Y Nutricion (Ciberobn), 15705 Santiago de Compostela A Coruña, Spain.
  13. National Centre for Register-Based Research, Department of Economics and Business Economics, Business and Social Sciences, Aarhus University and iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research (Copenhagen-Aarhus), DK-8210 Aarhus, Denmark.
  14. Department of Medical Sciences, School of Medicine, Hospital of Girona Dr. Josep Trueta, University of Girona, 17004 Girona, Spain.
  15. Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  16. Department of Endocrinology, Instituto de Investigación Sanitaria de Navarra, University of Navarra (IdiSNA), 31008 Pamplona, Spain.
  17. Unit of Cardiovascular Risk and Nutrition, Hospital del Mar Institute for Medical Research (IMIM), 08003 Barcelona, Spain.
  18. Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, 43201 Reus, Spain.
  19. Lipids and Vascular Risk Unit, Internal Medicine, University Hospital of Bellvitge (IDIBELL), L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
  20. Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  21. Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, Institute of Biomedical Research in Malaga (IBIMA), University of Malaga, 29016 Málaga, Spain.
  22. Integrative Pharmacology and Systems Neurosciences Research Group, Institut Hospital del Mar de Investigaciones Médicas Municipal d'Investigació Mèdica (IMIM), 08003 Barcelona, Spain.
  23. IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (DCEXS-UPF), 08003 Barcelona, Spain.
  24. Nutrition Unit, University Hospital of Sant Joan de Reus, 43204 Reus, Spain.
  25. Nutrition Research Group, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, 35001 Las Palmas de Gran Canaria, Spain.
  26. Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, 6211 LK Maastricht, The Netherlands.
  27. National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus University, DK-8000 Aarhus, Denmark.

PMID: 34959979 PMCID: PMC8707121 DOI: 10.3390/nu13124426

Abstract

Impulsive and compulsive behaviors have both been observed in individuals with obesity. The co-occurrence of obesity and type 2 diabetes (T2D) is more strongly associated with impulsivity, although there are no conclusive results yet. A multidimensional assessment of impulsivity and compulsivity was conducted in individuals with obesity in the absence or presence of T2D, compared with healthy, normal-weight individuals, with highly impulsive patients (gambling disorders), and with highly compulsive patients (anorexia nervosa). Decision making and novelty seeking were used to measure impulsivity, and cognitive flexibility and harm avoidance were used for compulsivity. For impulsivity, patients with obesity and T2D showed poorer decision-making ability compared with healthy individuals. For compulsivity, individuals with only obesity presented less cognitive flexibility and high harm avoidance; these dimensions were not associated with obesity with T2D. This study contributes to the knowledge of the mechanisms associated with diabetes and its association with impulsive-compulsive behaviors, confirming the hypothesis that patients with obesity and T2D would be characterized by higher levels of impulsivity.

Keywords: cognitive flexibility; compulsivity; decision making; harm avoidance; impulsivity; novelty seeking; type 2 diabetes

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