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Bissell BD, Campbell J, Collins R, et al. Major Publications in the Critical Care Pharmacotherapy Literature: 2020. Crit Care Explor. 2021;3(12):e0590doi: 10.1097/CCE.0000000000000590.
Bissell, B. D., Campbell, J., Collins, R., Cook, C., Desai, D., DeWitt, J., Eche, I. M., Eche, I. J., Elsamadisi, P., Juul, J., Kim, S., Makowski, C. T., Mylvaganam, R. J., Smith, A., Stancati, J., Stonesifer, K., Tawil, J., & Smith Condeni, M. (2021). Major Publications in the Critical Care Pharmacotherapy Literature: 2020. Critical care explorations, 3(12), e0590. https://doi.org/10.1097/CCE.0000000000000590
Bissell, Brittany D, et al. "Major Publications in the Critical Care Pharmacotherapy Literature: 2020." Critical care explorations vol. 3,12 (2021): e0590. doi: https://doi.org/10.1097/CCE.0000000000000590
Bissell BD, Campbell J, Collins R, Cook C, Desai D, DeWitt J, Eche IM, Eche IJ, Elsamadisi P, Juul J, Kim S, Makowski CT, Mylvaganam RJ, Smith A, Stancati J, Stonesifer K, Tawil J, Smith Condeni M. Major Publications in the Critical Care Pharmacotherapy Literature: 2020. Crit Care Explor. 2021 Dec 09;3(12):e0590. doi: 10.1097/CCE.0000000000000590. eCollection 2021 Dec. PMID: 34909697; PMCID: PMC8663877.
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Crit Care Explor. 2021 Dec 09;3(12):e0590. doi: 10.1097/CCE.0000000000000590. eCollection 2021 Dec.

Major Publications in the Critical Care Pharmacotherapy Literature: 2020.

Critical care explorations

Brittany D Bissell, Jeannee Campbell, Reagan Collins, Charles Cook, Dharati Desai, Jessica DeWitt, Ifeoma Mary Eche, Ijeoma Julie Eche, Pansy Elsamadisi, Janelle Juul, Soyoung Kim, Courtney T Makowski, Ruben J Mylvaganam, Adam Smith, Jennifer Stancati, Katherine Stonesifer, Justin Tawil, Melanie Smith Condeni

Affiliations

  1. University of Kentucky, Lexington, KY.
  2. The University of Texas MD Anderson Cancer Center, Houston, TX.
  3. Clinical Pharmacy Specialist in Critical Care and Nutrition Support, The University of Texas MD Anderson Cancer Center, Houston, TX.
  4. Beth Israel Deaconess Medical Center, Boston, MA.
  5. Advocate Christ Medical Center, Oak Lawn, IL.
  6. OhioHealth Riverside Methodist Hospital, Columbus, OH.
  7. Froedtert and the Medical College of Wisconsin, Milwaukee, WI.
  8. UPMC Pinnacle, Harrisburg, PA.
  9. Northwestern Memorial Hospital, Chicago, IL.
  10. Northwestern McGaw Medical Center, Chicago, IL.
  11. Medical University of South Carolina, Charleston, SC.

PMID: 34909697 PMCID: PMC8663877 DOI: 10.1097/CCE.0000000000000590

Abstract

OBJECTIVES: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2020.

DATA SOURCES: The Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update group screened 36 journals monthly for impactful publications.

STUDY SELECTION: The group reviewed a total of 119 articles during 2020 according to relevance for practice.

DATA EXTRACTION: Articles were selected with consensus and importance to clinical practice from those included in the monthly Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update. The group reviewed articles according to Grading of Recommendations, Assessment, Development, and Evaluations criteria. Articles with a 1A grade were selected.

DATA SYNTHESIS: Several trials were summarized, including two meta-analyses and five original research trials. Original research trials evaluating vitamin C, hydrocortisone, and thiamine versus hydrocortisone in sepsis, the use of nonsedation strategies, dexmedetomidine in cardiac surgery, remdesivir for severe acute respiratory syndrome coronavirus 2, and thrombectomy in acute ischemic stroke. Two meta-analyses determining the impact of norepinephrine initiation in patients with septic shock and the use of corticosteroids in severe acute respiratory syndrome coronavirus 2 was included.

CONCLUSIONS: This clinical review provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2020.

Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

Keywords: coronavirus disease 2019; critical care; drug therapy; review; sedation; septic shock

Conflict of interest statement

The authors have disclosed that they do not have any potential conflicts of interest.

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