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Biagiotti G, Angeli A, Giacomini A, et al. Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells. ACS Appl Nano Mater. 2021;4(12):14153-14160doi: 10.1021/acsanm.1c03603.
Biagiotti, G., Angeli, A., Giacomini, A., Toniolo, G., Landini, L., Salerno, G., Di Cesare Mannelli, L., Ghelardini, C., Mello, T., Mussi, S., Ravelli, C., Marelli, M., Cicchi, S., Menna, E., Ronca, R., Supuran, C. T., & Richichi, B. (2021). Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells. ACS applied nano materials, 4(12), 14153-14160. https://doi.org/10.1021/acsanm.1c03603
Biagiotti, Giacomo, et al. "Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells." ACS applied nano materials vol. 4,12 (2021): 14153-14160. doi: https://doi.org/10.1021/acsanm.1c03603
Biagiotti G, Angeli A, Giacomini A, Toniolo G, Landini L, Salerno G, Di Cesare Mannelli L, Ghelardini C, Mello T, Mussi S, Ravelli C, Marelli M, Cicchi S, Menna E, Ronca R, Supuran CT, Richichi B. Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells. ACS Appl Nano Mater. 2021 Dec 24;4(12):14153-14160. doi: 10.1021/acsanm.1c03603. Epub 2021 Nov 17. PMID: 34970641; PMCID: PMC8713163.
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ACS Appl Nano Mater. 2021 Dec 24;4(12):14153-14160. doi: 10.1021/acsanm.1c03603. Epub 2021 Nov 17.

Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells.

ACS applied nano materials

Giacomo Biagiotti, Andrea Angeli, Arianna Giacomini, Gianluca Toniolo, Luca Landini, Gianluca Salerno, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Tommaso Mello, Silvia Mussi, Cosetta Ravelli, Marcello Marelli, Stefano Cicchi, Enzo Menna, Roberto Ronca, Claudiu T Supuran, Barbara Richichi

Affiliations

  1. Department of Chemistry "Ugo Schiff", University of Firenze, Via della Lastruccia 13, Sesto Fiorentino, 50019 Florence, Italy.
  2. Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM, Via G. Giusti, 9, 50121 Firenze, Florence, Italy.
  3. Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA, Section of Pharmaceutical Chemistry, University of Firenze, Via Ugo Schiff 7, Sesto Fiorentino, 50019 Florence, Italy.
  4. Department of Molecular and translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
  5. Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Firenze, V.le Pieraccini 6, 50139 Firenze, Florence, Italy.
  6. Department of Clinical and Experimental Biomedical Sciences "Mario Serio"-Gastroenterology Unit, University of Firenze, V.le Pieraccini 6, 50139 Firenze, Florence, Italy.
  7. Istituto di scienze e tecnologie chimiche "Giulio Natta", CNR-SCITEC, Sede Fantoli, Via Fantoli 16/15, 20138 Milano Italy.
  8. Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy.
  9. Centre for Mechanics of Biological Materials-CMBM, Via Marzolo 9, 35131 Padova, Italy.

PMID: 34970641 PMCID: PMC8713163 DOI: 10.1021/acsanm.1c03603

Abstract

The bioimaging of cancer cells by the specific targeting of overexpressed biomarkers is an approach that holds great promise in the identification of selective diagnostic tools. Tumor-associated human carbonic anhydrase (hCA) isoforms IX and XII have been considered so far as well-defined biomarkers, with their expression correlating with cancer progression and aggressiveness. Therefore, the availability of highly performant fluorescent tools tailored for their targeting and able to efficiently visualize such key targets is in high demand. We report here on the design and synthesis of a kind of quantum dot (QD)-based fluorescent glyconanoprobe coated with a binary mixture of ligands, which, according to the structure of the terminal domains, impart specific property sets to the fluorescent probe. Specifically, monosaccharide residues ensured the dispersibility in the biological medium, CA inhibitor residues provided specific targeting of membrane-anchored hCA IX overexpressed on bladder cancer cells, and the quantum dots imparted the optical/fluorescence properties.

© 2021 The Authors. Published by American Chemical Society.

Conflict of interest statement

The authors declare no competing financial interest.

References

  1. Metabolites. 2020 Oct 14;10(10): - PubMed
  2. Bioorg Med Chem. 2017 Jul 1;25(13):3567-3573 - PubMed
  3. J Am Chem Soc. 2018 Feb 7;140(5):1617-1621 - PubMed
  4. ACS Nano. 2008 Aug;2(8):1514-6 - PubMed
  5. Chem Commun (Camb). 2020 Apr 25;56(32):4444-4447 - PubMed
  6. Bioconjug Chem. 2011 May 18;22(5):825-58 - PubMed
  7. Nat Rev Drug Discov. 2008 Feb;7(2):168-81 - PubMed
  8. Gastroenterology. 2019 Sep;157(3):823-837 - PubMed
  9. J Biol Chem. 1971 Apr 25;246(8):2561-73 - PubMed
  10. J Am Chem Soc. 2006 Jun 28;128(25):8329-35 - PubMed
  11. Eur J Med Chem. 2020 Sep 15;202:112509 - PubMed
  12. J Exp Pharmacol. 2020 Dec 15;12:603-617 - PubMed
  13. Beilstein J Org Chem. 2017 May 24;13:1008-1021 - PubMed
  14. Mol Cancer Ther. 2019 Sep;18(9):1544-1554 - PubMed
  15. Nanoscale. 2018 Nov 1;10(42):19720-19732 - PubMed
  16. PLoS One. 2012;7(11):e50860 - PubMed
  17. J Med Chem. 2005 Jul 28;48(15):4834-41 - PubMed
  18. Radiother Oncol. 2009 Sep;92(3):423-8 - PubMed
  19. J Am Chem Soc. 2008 Dec 3;130(48):16130-1 - PubMed
  20. Bioorg Med Chem. 2010 Jul 15;18(14):5234-40 - PubMed
  21. Small. 2009 Feb;5(2):154-68 - PubMed
  22. Analyst. 2016 Dec 19;142(1):11-29 - PubMed
  23. Chem Soc Rev. 2015 Jul 21;44(14):4792-834 - PubMed
  24. Clin Exp Metastasis. 2021 May 17;: - PubMed
  25. Nanomedicine (Lond). 2017 Jan;12(1):13-23 - PubMed
  26. Anal Chem. 2011 Dec 1;83(23):8826-37 - PubMed
  27. Chem Soc Rev. 2013 Jun 7;42(11):4728-45 - PubMed
  28. Nat Rev Drug Discov. 2011 Sep 16;10(10):767-77 - PubMed
  29. ACS Omega. 2020 Sep 30;5(40):26077-26083 - PubMed
  30. Bioconjug Chem. 2019 Jan 16;30(1):54-62 - PubMed
  31. Chemistry. 2015 Jul 13;21(29):10306-9 - PubMed
  32. ACS Med Chem Lett. 2018 Aug 29;9(9):947-951 - PubMed
  33. Trends Cancer. 2016 Dec;2(12):758-770 - PubMed
  34. Exp Cell Res. 2017 Jul 15;356(2):116-121 - PubMed
  35. Am J Clin Oncol. 2020 Jul;43(7):484-490 - PubMed

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