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Delmas C, Roubille F, Lamblin N, et al. Baseline characteristics, management, and predictors of early mortality in cardiogenic shock: insights from the FRENSHOCK registry. ESC Heart Fail. 2021;doi: 10.1002/ehf2.13734.
Delmas, C., Roubille, F., Lamblin, N., Bonello, L., Leurent, G., Levy, B., Elbaz, M., Danchin, N., Champion, S., Lim, P., Schneider, F., Cariou, A., Khachab, H., Bourenne, J., Seronde, M. F., Schurtz, G., Harbaoui, B., Vanzetto, G., Quentin, C., Delabranche, X., Aissaoui, N., Combaret, N., Manzo-Silberman, S., Tomasevic, D., Marchandot, B., Lattuca, B., Henry, P., Gerbaud, E., Bonnefoy, E., & Puymirat, E. (2021). Baseline characteristics, management, and predictors of early mortality in cardiogenic shock: insights from the FRENSHOCK registry. ESC heart failure, . https://doi.org/10.1002/ehf2.13734
Delmas, Clement, et al. "Baseline characteristics, management, and predictors of early mortality in cardiogenic shock: insights from the FRENSHOCK registry." ESC heart failure vol. (2021). doi: https://doi.org/10.1002/ehf2.13734
Delmas C, Roubille F, Lamblin N, Bonello L, Leurent G, Levy B, Elbaz M, Danchin N, Champion S, Lim P, Schneider F, Cariou A, Khachab H, Bourenne J, Seronde MF, Schurtz G, Harbaoui B, Vanzetto G, Quentin C, Delabranche X, Aissaoui N, Combaret N, Manzo-Silberman S, Tomasevic D, Marchandot B, Lattuca B, Henry P, Gerbaud E, Bonnefoy E, Puymirat E. Baseline characteristics, management, and predictors of early mortality in cardiogenic shock: insights from the FRENSHOCK registry. ESC Heart Fail. 2021 Dec 31; doi: 10.1002/ehf2.13734. Epub 2021 Dec 31. PMID: 34973047.
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ESC Heart Fail. 2021 Dec 31; doi: 10.1002/ehf2.13734. Epub 2021 Dec 31.

Baseline characteristics, management, and predictors of early mortality in cardiogenic shock: insights from the FRENSHOCK registry.

ESC heart failure

Clement Delmas, François Roubille, Nicolas Lamblin, Laurent Bonello, Guillaume Leurent, Bruno Levy, Meyer Elbaz, Nicolas Danchin, Sebastien Champion, Pascal Lim, Francis Schneider, Alain Cariou, Hadi Khachab, Jeremy Bourenne, Marie-France Seronde, Guillaume Schurtz, Brahim Harbaoui, Gerald Vanzetto, Charlotte Quentin, Xavier Delabranche, Nadia Aissaoui, Nicolas Combaret, Stephane Manzo-Silberman, Danka Tomasevic, Benjamin Marchandot, Benoit Lattuca, Patrick Henry, Edouard Gerbaud, Eric Bonnefoy, Etienne Puymirat

Affiliations

  1. Intensive Cardiac Care Unit, Rangueil University Hospital/Institute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), 1 Avenue Jean Poulhes, Toulouse, 31059, France.
  2. PhyMedExp, Université de Montpellier, INSERM, CNRS, Cardiology Department, CHU de Montpellier, Montpellier, France.
  3. Urgences et Soins Intensifs de Cardiologie, CHU Lille, University of Lille, Inserm U1167, Lille, France.
  4. Aix-Marseille Université; Intensive Care Unit, Department of Cardiology, Assistance Publique-Hôpitaux de Marseille, Hôpital Nord; Mediterranean Association for Research and Studies in Cardiology (MARS Cardio), Marseille, France.
  5. Department of Cardiology, CHU Rennes, Inserm, LTSI-UMR 1099, Univ Rennes 1, Rennes, France.
  6. Réanimation Médicale Brabois, CHRU Nancy, Nancy, France.
  7. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, Department of Cardiology, Université de Paris, Paris, France.
  8. Clinique de Parly 2, Ramsay Générale de Santé, Le Chesnay, France.
  9. Univ Paris Est Créteil, INSERM, IMRB; AP-HP, Hôpital Universitaire Henri-Mondor, Service de Cardiologie, Créteil, France.
  10. Médecine Intensive-Réanimation, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
  11. Medical Intensive Care Unit, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris, Medical School, Paris, France.
  12. Intensive Cardiac Care Unit, Department of Cardiology, CH d'Aix en Provence, Aix-en-Provence, France.
  13. Aix Marseille Université, Service de Réanimation des Urgences, CHU La Timone 2, Marseille, France.
  14. Service de Cardiologie, CHU Besançon, Besançon, France.
  15. Cardiology Department, Hôpital Croix-Rousse and Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France, University of Lyon, CREATIS UMR5220; INSERM U1044; INSA-15, Lyon, France.
  16. Department of Cardiology, Hôpital de Grenoble, Grenoble, France.
  17. Service de Reanimation Polyvalente, Centre Hospitalier Broussais St Malo, Saint-Malo, France.
  18. Réanimation Chirurgicale Polyvalente, Pôle Anesthésie-Réanimation chirurgicale-Médecine Péri-opératoire, Les Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil 1, Porte de l'Hôpital, Strasbourg, France.
  19. Médecine Intensive Réanimation, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France.
  20. Department of Cardiology, CHU Clermont-Ferrand, CNRS, Université Clermont Auvergne, Clermont-Ferrand, France.
  21. Department of Cardiology, Université de Paris, Hôpital Lariboisière, AP-HP, Paris, France.
  22. Intensive Cardiac Care Unit, Lyon Brom University Hospital, Lyon, France.
  23. Université de Strasbourg, Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Strasbourg, France.
  24. Department of Cardiology, Nîmes University Hospital, Montpellier University, Nîmes, France.
  25. Cardiology Intensive Care Unit and Interventional Cardiology, Hôpital Cardiologique du Haut Lévêque, Bordeaux Cardio-Thoracic Research Centre, U1045, Bordeaux University, Hôpital Xavier Arnozan, Pessac, France.

PMID: 34973047 DOI: 10.1002/ehf2.13734

Abstract

AIMS: Published data on cardiogenic shock (CS) are scarce and are mostly focused on small registries of selected populations. The aim of this study was to examine the current CS picture and define the independent correlates of 30 day mortality in a large non-selected cohort.

METHODS AND RESULTS: FRENSHOCK is a prospective multicentre observational survey conducted in metropolitan French intensive care units and intensive cardiac care units between April and October 2016. There were 772 patients enrolled (mean age 65.7 ± 14.9 years; 71.5% male). Of these patients, 280 (36.3%) had ischaemic CS. Organ replacement therapies (respiratory support, circulatory support or renal replacement therapy) were used in 58.3% of patients. Mortality at 30 days was 26.0% in the overall population (16.7% to 48.0% depending on the main cause and first place of admission). Multivariate analysis showed that six independent factors were associated with a higher 30 day mortality: age [per year, odds ratio (OR) 1.06, 95% confidence interval (CI): 1.04-1.08], diuretics (OR 1.74, 95% CI: 1.05-2.88), circulatory support (OR 1.92, 95% CI: 1.12-3.29), left ventricular ejection fraction <30% (OR 2.15, 95% CI: 1.40-3.29), norepinephrine (OR 2.55, 95% CI: 1.69-3.84), and renal replacement therapy (OR 2.72, 95% CI: 1.65-4-49).

CONCLUSIONS: Non-ischaemic CS accounted for more than 60% of all cases of CS. CS is still associated with significant but variable short-term mortality according to the cause and first place of admission, despite frequent use of haemodynamic support, and organ replacement therapies.

© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

Keywords: Cardiogenic shock; Epidemiology; Mortality; Organ support

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