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, Hage CA, Klesney-Tait J, et al. Extracorporeal photopheresis to attenuate decline in lung function due to refractory obstructive allograft dysfunction. Transfus Med. 2021;31(4):292-302doi: 10.1111/tme.12779.
, Hage, C. A., Klesney-Tait, J., Wille, K., Arcasoy, S., Yung, G., Hertz, M., Chan, K. M., Morrell, M., Goldberg, H., Vedantham, S., Derfler, M. C., Commean, P., Berman, K., Spitznagel, E., Atkinson, J., & Despotis, G. (2021). Extracorporeal photopheresis to attenuate decline in lung function due to refractory obstructive allograft dysfunction. Transfusion medicine (Oxford, England), 31(4), 292-302. https://doi.org/10.1111/tme.12779
, et al. "Extracorporeal photopheresis to attenuate decline in lung function due to refractory obstructive allograft dysfunction." Transfusion medicine (Oxford, England) vol. 31,4 (2021): 292-302. doi: https://doi.org/10.1111/tme.12779
, Hage CA, Klesney-Tait J, Wille K, Arcasoy S, Yung G, Hertz M, Chan KM, Morrell M, Goldberg H, Vedantham S, Derfler MC, Commean P, Berman K, Spitznagel E, Atkinson J, Despotis G. Extracorporeal photopheresis to attenuate decline in lung function due to refractory obstructive allograft dysfunction. Transfus Med. 2021 Aug;31(4):292-302. doi: 10.1111/tme.12779. Epub 2021 May 05. PMID: 33955079; PMCID: PMC8453798.
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Transfus Med. 2021 Aug;31(4):292-302. doi: 10.1111/tme.12779. Epub 2021 May 05.

Extracorporeal photopheresis to attenuate decline in lung function due to refractory obstructive allograft dysfunction.

Transfusion medicine (Oxford, England)

Chadi A Hage, Julia Klesney-Tait, Keith Wille, Selim Arcasoy, Gordon Yung, Marshall Hertz, Kevin M Chan, Matt Morrell, Hilary Goldberg, Suresh Vedantham, Mary Clare Derfler, Paul Commean, Keith Berman, Ed Spitznagel, Jeff Atkinson, George Despotis

Affiliations

  1. Department of Medicine, Division of Pulmonology, Indiana University, Bloomington, Indiana, USA.
  2. Department of Medicine, Division of Pulmonology, University of Iowa, Iowa City, Iowa, USA.
  3. Department of Medicine, Division of Pulmonology, University of Alabama, Tuscaloosa, Alabama, USA.
  4. Department of Medicine, Division of Pulmonology, Columbia University of Alabama, Orange Beach, Alabama, USA.
  5. Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, USA.
  6. Department of Medicine, Division of Pulmonology, University of Minnesota, Minneapolis, Minnesota, USA.
  7. Department of Medicine, Division of Pulmonology, University of Michigan, Ann Arbor, Michigan, USA.
  8. Department of Medicine, Division of Pulmonology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  9. Harvard Medical School, Department of Medicine, Division of Pulmonology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  10. Clinical Coordinating Center, Washington University School of Medicine, Mallinckrodt Institute of Radiology, St. Louis, Missouri, USA.
  11. Data Coordinating Center, Washington University School of Medicine, Mallinckrodt Institute of Radiology, St. Louis, Missouri, USA.
  12. Health Research Associates, Mountlake Terrace, Washington, USA.
  13. Department of Mathematics, Washington University, St. Louis, Missouri, USA.
  14. Department of Internal Medicine, Division of Pulmonary Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
  15. Department of Pathology & Immunology, Division of Laboratory & Genomic Medicine, Department of Anesthesiology, Division of Cardiothoracic Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.

PMID: 33955079 PMCID: PMC8453798 DOI: 10.1111/tme.12779

Abstract

BACKGROUND: This study was designed to prospectively evaluate the efficacy of extracorporeal photopheresis (ECP) to attenuate the rate of decline of FEV

STUDY DESIGN AND METHODS: Subjects from 10 lung transplant centres were assigned to ECP treatment or to observation based on spirometric criteria, with potential crossover for those under observation. The primary endpoint of this study was to assess response to ECP (i.e., greater than a 50% decrease in the rate of FEV

RESULTS: Of 44 enrolled subjects, 31 were assigned to ECP treatment while 13 were initially assigned to observation on a non-random basis using specific spirometric inclusion criteria (seven of the observation patients subsequently crossed over to receive ECP). Of evaluable patients, 95% of patients initially assigned to treatment responded to ECP with rates of FEV

CONCLUSIONS: These analyses suggest that earlier detection and treatment of BOS should be considered to appreciate improved outcomes with ECP.

© 2021 The Authors. Transfusion Medicine published by John Wiley & Sons Ltd on behalf of British Blood Transfusion Society.

Keywords: bronchiolitis obliterans syndrome; extracorporeal photopheresis; forced expiratory volume in 1 s; lung transplantation

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