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Showing 1 to 12 of 113 entries
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Pulmonary lobe separation in expiration chest CT scans based on subject-specific priors derived from inspiration scans.

Journal of medical imaging (Bellingham, Wash.)

Bauer C, Eberlein M, Beichel RR.
PMID: 29487878
J Med Imaging (Bellingham). 2018 Jan;5(1):014003. doi: 10.1117/1.JMI.5.1.014003. Epub 2018 Feb 09.

Segmentation of pulmonary lobes in inspiration and expiration chest CT scan pairs is an important prerequisite for lobe-based quantitative disease assessment. Conventional methods process each CT scan independently, resulting typically in lower segmentation performance at expiration compared to inspiration....

Donor to recipient sizing in thoracic organ transplantation.

World journal of transplantation

Eberlein M, Reed RM.
PMID: 27011913
World J Transplant. 2016 Mar 24;6(1):155-64. doi: 10.5500/wjt.v6.i1.155.

Donor-to-recipient organ size matching is a critical aspect of thoracic transplantation. In the United States potential recipients for lung transplant and heart transplant are listed with limitations on donor height and weight ranges, respectively. Height is used as a...

Intrapulmonary Versus Nasal Transduction of Murine Airways With GP64-pseudotyped Viral Vectors.

Molecular therapy. Nucleic acids

Oakland M, Maury W, McCray PB, Sinn PL.
PMID: 23360952
Mol Ther Nucleic Acids. 2013 Jan 29;2:e69. doi: 10.1038/mtna.2012.60.

Persistent viral vector-mediated transgene expression in the airways requires delivery to cells with progenitor capacity and avoidance of immune responses. Previously, we observed that GP64-pseudotyped feline immunodeficiency virus (FIV)-mediated gene transfer was more efficient in the nasal airways than...

Lung transplantation: chronic rejection and stem cell depletion.

Journal of thoracic disease

Lynch TJ, Ahlers BA, Parekh KR.
PMID: 30233912
J Thorac Dis. 2018 Aug;10(8):E666-E668. doi: 10.21037/jtd.2018.07.70.

No abstract available.

Is Total Pancreatectomy with Islet Autotransplantation A Reasonable Choice for Pediatric Pancreatitis?.

JOP : Journal of the pancreas

Azhari H, Rahhal R, Uc A.
PMID: 26523129
JOP. 2015;16(4):335-41. Epub 2015 Jul 08.

Chronic pancreatitis is an emerging and poorly understood disease in childhood. Total pancreatectomy with islet cell autotransplantation is being proposed as a treatment for chronic pancreatitis and recent studies report a more favorable outcome in children compared to adults....

Cystic fibrosis related diabetes: Pathophysiology, screening and diagnosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Granados A, Chan CL, Ode KL, Moheet A, Moran A, Holl R.
PMID: 31679726
J Cyst Fibros. 2019 Oct;18:S3-S9. doi: 10.1016/j.jcf.2019.08.016.

Cystic fibrosis related diabetes (CFRD) is a distinct form of diabetes that is associated with significantly increased morbidity and mortality in the CF population. The primary etiology is relative insulin insufficiency secondary to destruction of pancreatic islets, and to...

Regional Gas Transport During Conventional and Oscillatory Ventilation Assessed by Xenon-Enhanced Computed Tomography.

Annals of biomedical engineering

Herrmann J, Gerard SE, Reinhardt JM, Hoffman EA, Kaczka DW.
PMID: 33948747
Ann Biomed Eng. 2021 Sep;49(9):2377-2388. doi: 10.1007/s10439-021-02767-2. Epub 2021 May 04.

Enhanced intrapulmonary gas transport enables oscillatory ventilation modalities to support gas exchange using extremely low tidal volumes at high frequencies. However, it is unknown whether gas transport rates can be improved by combining multiple frequencies of oscillation simultaneously. The...

Extracorporeal photopheresis to attenuate decline in lung function due to refractory obstructive allograft dysfunction.

Transfusion medicine (Oxford, England)

, Hage CA, Klesney-Tait J, Wille K, Arcasoy S, Yung G, Hertz M, Chan KM, Morrell M, Goldberg H, Vedantham S, Derfler MC, Commean P, Berman K, Spitznagel E, Atkinson J, Despotis G.
PMID: 33955079
Transfus Med. 2021 Aug;31(4):292-302. doi: 10.1111/tme.12779. Epub 2021 May 05.

BACKGROUND: This study was designed to prospectively evaluate the efficacy of extracorporeal photopheresis (ECP) to attenuate the rate of decline of FEVSTUDY DESIGN AND METHODS: Subjects from 10 lung transplant centres were assigned to ECP treatment or to observation...

Soluble Suppression of Tumorigenicity-2 Associates With Ventilator Dependence in Coronavirus Disease 2019 Respiratory Failure.

Critical care explorations

Alladina JW, Giacona FL, White EB, Brait KL, Abe EA, Michelhaugh SA, Hibbert KA, Januzzi JL, Thompson BT, Cho JL, Medoff BD.
PMID: 34235459
Crit Care Explor. 2021 Jun 29;3(7):e0480. doi: 10.1097/CCE.0000000000000480. eCollection 2021 Jul.

OBJECTIVES: We hypothesize that elevated soluble suppression of tumorigenicity-2 concentrations, a marker of pulmonary epithelial injury, reflect ongoing lung injury in acute hypoxemic respiratory failure due to coronavirus disease 2019 and associate with continued ventilator dependence.DESIGN: We associated serial...

Reconsidering the Utility of Race-Specific Lung Function Prediction Equations.

American journal of respiratory and critical care medicine

Baugh AD, Shiboski S, Hansel NN, Ortega V, Barjakteravic I, Barr RG, Bowler R, Comellas AP, Cooper CB, Couper D, Criner G, Curtis JL, Dransfield M, Ejike C, Han M, Hoffman E, Krishnan J, Krishnan JA, Mannino D, Paine Iii R, Parekh T, Peters S, Putcha N, Rennard S, Thakur N, Woodruff PG.
PMID: 34913855
Am J Respir Crit Care Med. 2021 Dec 16; doi: 10.1164/rccm.202105-1246OC. Epub 2021 Dec 16.

RATIONALE: African Americans have worse outcomes in chronic obstructive pulmonary disease (COPD).OBJECTIVE: Assess whether race-specific approaches for estimating lung function contribute to racial inequities by failing to recognize pathological decrements and considering them normal.METHODS: In a cohort with and...

Differential gene expression analysis for multi-subject single cell RNA sequencing studies with aggregateBioVar.

Bioinformatics (Oxford, England)

Thurman AL, Ratcliff JA, Chimenti MS, Pezzulo AA.
PMID: 33970215
Bioinformatics. 2021 May 10; doi: 10.1093/bioinformatics/btab337. Epub 2021 May 10.

MOTIVATION: Single cell RNA sequencing (scRNA-seq) studies provide more granular biological information than bulk RNA sequencing, but bulk RNA sequencing has remained popular due to relatively lower costs per sample, which has allowed investigators to process more biological replicates...

Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors.

Nucleic acids research

Krishnamurthy S, Traore S, Cooney AL, Brommel CM, Kulhankova K, Sinn PL, Newby GA, Liu DR, McCray PB.
PMID: 34520545
Nucleic Acids Res. 2021 Oct 11;49(18):10558-10572. doi: 10.1093/nar/gkab788.

Mutations in the CFTR gene that lead to premature stop codons or splicing defects cause cystic fibrosis (CF) and are not amenable to treatment by small-molecule modulators. Here, we investigate the use of adenine base editor (ABE) ribonucleoproteins (RNPs)...

Showing 1 to 12 of 113 entries