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Simone D, Penkava F, Ridley A, et al. Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates. Commun Biol. 2021;4(1):1395doi: 10.1038/s42003-021-02931-3.
Simone, D., Penkava, F., Ridley, A., Sansom, S., Al-Mossawi, M. H., & Bowness, P. (2021). Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates. Communications biology, 4(1), 1395. https://doi.org/10.1038/s42003-021-02931-3
Simone, Davide, et al. "Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates." Communications biology vol. 4,1 (2021): 1395. doi: https://doi.org/10.1038/s42003-021-02931-3
Simone D, Penkava F, Ridley A, Sansom S, Al-Mossawi MH, Bowness P. Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates. Commun Biol. 2021 Dec 14;4(1):1395. doi: 10.1038/s42003-021-02931-3. PMID: 34907325; PMCID: PMC8671562.
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Commun Biol. 2021 Dec 14;4(1):1395. doi: 10.1038/s42003-021-02931-3.

Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates.

Communications biology

Davide Simone, Frank Penkava, Anna Ridley, Stephen Sansom, M Hussein Al-Mossawi, Paul Bowness

Affiliations

  1. Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK. [email protected].
  2. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. [email protected].
  3. Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.
  4. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
  5. Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK. [email protected].

PMID: 34907325 PMCID: PMC8671562 DOI: 10.1038/s42003-021-02931-3

Abstract

Regulatory T cells (Tregs) play an important role in controlling inflammation and limiting autoimmunity, but their phenotypes at inflammatory sites in human disease are poorly understood. We here analyze the single-cell transcriptome of >16,000 Tregs obtained from peripheral blood and synovial fluid of two patients with HLA-B27+ ankylosing spondylitis and three patients with psoriatic arthritis, closely related forms of inflammatory spondyloarthritis. We identify multiple Treg clusters with distinct transcriptomic profiles, including, among others, a regulatory CD8

© 2021. The Author(s).

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