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Belser JA, Pulit-Penaloza JA, Brock N, et al. Inherent heterogeneity of influenza A virus stability following aerosolization. Appl Environ Microbiol. 2022;aem0227121doi: 10.1128/aem.02271-21.
Belser, J. A., Pulit-Penaloza, J. A., Brock, N., Creager, H. M., Gustin, K. M., Tumpey, T. M., & Maines, T. R. (2022). Inherent heterogeneity of influenza A virus stability following aerosolization. Applied and environmental microbiology, aem0227121. https://doi.org/10.1128/aem.02271-21
Belser, Jessica A, et al. "Inherent heterogeneity of influenza A virus stability following aerosolization." Applied and environmental microbiology vol. (2022): aem0227121. doi: https://doi.org/10.1128/aem.02271-21
Belser JA, Pulit-Penaloza JA, Brock N, Creager HM, Gustin KM, Tumpey TM, Maines TR. Inherent heterogeneity of influenza A virus stability following aerosolization. Appl Environ Microbiol. 2022 Jan 05;aem0227121. doi: 10.1128/aem.02271-21. Epub 2022 Jan 05. PMID: 34985975.
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Appl Environ Microbiol. 2022 Jan 05;aem0227121. doi: 10.1128/aem.02271-21. Epub 2022 Jan 05.

Inherent heterogeneity of influenza A virus stability following aerosolization.

Applied and environmental microbiology

Jessica A Belser, Joanna A Pulit-Penaloza, Nicole Brock, Hannah M Creager, Kortney M Gustin, Terrence M Tumpey, Taronna R Maines

Affiliations

  1. Influenza Division, Centers for Disease Control Prevention, Atlanta, GA 30329.

PMID: 34985975 DOI: 10.1128/aem.02271-21

Abstract

Efficient human-to-human transmission represents a necessary adaptation for a zoonotic influenza A virus (IAV) to cause a pandemic. As such, many emerging IAVs are characterized for transmissibility phenotypes in mammalian models, with an emphasis on elucidating viral determinants of transmission and the role host immune responses contribute to mammalian adaptation. Investigations of virus infectivity and stability in aerosols concurrent with transmission assessments have increased in recent years, enhancing our understanding of this dynamic process. Here, we employ a diverse panel of 17 human and zoonotic IAVs, inclusive of seasonally circulating H1N1 and H3N2 viruses, and avian and swine viruses associated with human infection, to evaluate differences in spray factor (a value that assesses efficiency of the aerosolization process), stability, and infectivity following aerosolization. While most seasonal influenza viruses did not exhibit substantial variability within these parameters, there was more heterogeneity among zoonotic influenza viruses, which possess a diverse range of transmission phenotypes. Aging of aerosols at different relative humidities identified strain-specific levels of stability with different profiles identified between zoonotic H3, H5, and H7 subtype viruses associated with human infection. As studies continue to elucidate the complex components governing virus transmissibility, notably aerosol matrices and environmental parameters, considering the relative role of subtype- and strain-specific factors to modulate these parameters will improve our understanding of the pandemic potential of zoonotic influenza A viruses.

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