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An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial.

NPJ vaccines

DeZure AD, Coates EE, Hu Z, Yamshchikov GV, Zephir KL, Enama ME, Plummer SH, Gordon IJ, Kaltovich F, Andrews S, McDermott A, Crank MC, Koup RA, Schwartz RM, Bailer RT, Sun X, Mascola JR, Tumpey TM, Graham BS, Ledgerwood JE.
PMID: 29263871
NPJ Vaccines. 2017 Jun 01;2:15. doi: 10.1038/s41541-017-0016-6. eCollection 2017.

A novel avian influenza subtype, A/H7N9, emerged in 2013 and represents a public health threat with pandemic potential. We have previously shown that DNA vaccine priming increases the magnitude and quality of antibody responses to H5N1 monovalent inactivated boost....

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DeZure AD, Coates EE, Hu Z, et al. An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial. NPJ Vaccines. 2017;2:15doi: 10.1038/s41541-017-0016-6.
DeZure, A. D., Coates, E. E., Hu, Z., Yamshchikov, G. V., Zephir, K. L., Enama, M. E., Plummer, S. H., Gordon, I. J., Kaltovich, F., Andrews, S., McDermott, A., Crank, M. C., Koup, R. A., Schwartz, R. M., Bailer, R. T., Sun, X., Mascola, J. R., Tumpey, T. M., Graham, B. S., & Ledgerwood, J. E. (2017). An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial. NPJ vaccines, 215. https://doi.org/10.1038/s41541-017-0016-6
DeZure, Adam D, et al. "An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial." NPJ vaccines vol. 2 (2017): 15. doi: https://doi.org/10.1038/s41541-017-0016-6
DeZure AD, Coates EE, Hu Z, Yamshchikov GV, Zephir KL, Enama ME, Plummer SH, Gordon IJ, Kaltovich F, Andrews S, McDermott A, Crank MC, Koup RA, Schwartz RM, Bailer RT, Sun X, Mascola JR, Tumpey TM, Graham BS, Ledgerwood JE. An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial. NPJ Vaccines. 2017 Jun 01;2:15. doi: 10.1038/s41541-017-0016-6. eCollection 2017. PMID: 29263871; PMCID: PMC5627236.
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Correction for Sun et al., "Risk Assessment of Fifth-Wave H7N9 Influenza A Viruses in Mammalian Models".

Journal of virology

Sun X, Belser JA, Pappas C, Pulit-Penaloza JA, Brock N, Zeng H, Creager HM, Le S, Wilson M, Lewis A, Stark TJ, Shieh WJ, Barnes J, Tumpey TM, Maines TR.
PMID: 31201279
J Virol. 2019 Jun 14;93(13). doi: 10.1128/JVI.00476-19. Print 2019 Jul 01.

No abstract available.

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Sun X, Belser JA, Pappas C, et al. Correction for Sun et al., "Risk Assessment of Fifth-Wave H7N9 Influenza A Viruses in Mammalian Models". J Virol. 2019;93(13)doi: 10.1128/JVI.00476-19.
Sun, X., Belser, J. A., Pappas, C., Pulit-Penaloza, J. A., Brock, N., Zeng, H., Creager, H. M., Le, S., Wilson, M., Lewis, A., Stark, T. J., Shieh, W. J., Barnes, J., Tumpey, T. M., & Maines, T. R. (2019). Correction for Sun et al., "Risk Assessment of Fifth-Wave H7N9 Influenza A Viruses in Mammalian Models". Journal of virology, 93(13), . https://doi.org/10.1128/JVI.00476-19
Sun, Xiangjie, et al. "Correction for Sun et al., "Risk Assessment of Fifth-Wave H7N9 Influenza A Viruses in Mammalian Models"." Journal of virology vol. 93,13 (2019). doi: https://doi.org/10.1128/JVI.00476-19
Sun X, Belser JA, Pappas C, Pulit-Penaloza JA, Brock N, Zeng H, Creager HM, Le S, Wilson M, Lewis A, Stark TJ, Shieh WJ, Barnes J, Tumpey TM, Maines TR. Correction for Sun et al., "Risk Assessment of Fifth-Wave H7N9 Influenza A Viruses in Mammalian Models". J Virol. 2019 Jun 14;93(13). doi: 10.1128/JVI.00476-19. Print 2019 Jul 01. PMID: 31201279; PMCID: PMC6580968.
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Renewed global partnerships and redesigned roadmaps for rabies prevention and control.

Veterinary medicine international

Lembo T, Attlan M, Bourhy H, Cleaveland S, Costa P, de Balogh K, Dodet B, Fooks AR, Hiby E, Leanes F, Meslin FX, Miranda ME, Müller T, Nel LH, Rupprecht CE, Tordo N, Tumpey A, Wandeler A, Briggs DJ.
PMID: 21776359
Vet Med Int. 2011;2011:923149. doi: 10.4061/2011/923149. Epub 2011 Jun 01.

Canine rabies, responsible for most human rabies deaths, is a serious global public health concern. This zoonosis is entirely preventable, but by focusing solely upon rabies prevention in humans, this "incurable wound" persists at high costs. Although preventing human...

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Lembo T, Attlan M, Bourhy H, et al. Renewed global partnerships and redesigned roadmaps for rabies prevention and control. Vet Med Int. 2011;2011:923149doi: 10.4061/2011/923149.
Lembo, T., Attlan, M., Bourhy, H., Cleaveland, S., Costa, P., de Balogh, K., Dodet, B., Fooks, A. R., Hiby, E., Leanes, F., Meslin, F. X., Miranda, M. E., Müller, T., Nel, L. H., Rupprecht, C. E., Tordo, N., Tumpey, A., Wandeler, A., & Briggs, D. J. (2011). Renewed global partnerships and redesigned roadmaps for rabies prevention and control. Veterinary medicine international, 2011923149. https://doi.org/10.4061/2011/923149
Lembo, Tiziana, et al. "Renewed global partnerships and redesigned roadmaps for rabies prevention and control." Veterinary medicine international vol. 2011 (2011): 923149. doi: https://doi.org/10.4061/2011/923149
Lembo T, Attlan M, Bourhy H, Cleaveland S, Costa P, de Balogh K, Dodet B, Fooks AR, Hiby E, Leanes F, Meslin FX, Miranda ME, Müller T, Nel LH, Rupprecht CE, Tordo N, Tumpey A, Wandeler A, Briggs DJ. Renewed global partnerships and redesigned roadmaps for rabies prevention and control. Vet Med Int. 2011;2011:923149. doi: 10.4061/2011/923149. Epub 2011 Jun 01. PMID: 21776359; PMCID: PMC3135331.
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The Mitochondrial GTPase Gem1 Contributes to the Cell Wall Stress Response and Invasive Growth of .

Frontiers in microbiology

Koch B, Tucey TM, Lo TL, Novakovic S, Boag P, Traven A.
PMID: 29326680
Front Microbiol. 2017 Dec 20;8:2555. doi: 10.3389/fmicb.2017.02555. eCollection 2017.

The interactions of mitochondria with the endoplasmic reticulum (ER) are crucial for maintaining proper mitochondrial morphology, function and dynamics. This enables cells to utilize their mitochondria optimally for energy production and anabolism, and it further provides for metabolic control...

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Koch B, Tucey TM, Lo TL, et al. The Mitochondrial GTPase Gem1 Contributes to the Cell Wall Stress Response and Invasive Growth of . Front Microbiol. 2017;8:2555doi: 10.3389/fmicb.2017.02555.
Koch, B., Tucey, T. M., Lo, T. L., Novakovic, S., Boag, P., & Traven, A. (2017). The Mitochondrial GTPase Gem1 Contributes to the Cell Wall Stress Response and Invasive Growth of . Frontiers in microbiology, 82555. https://doi.org/10.3389/fmicb.2017.02555
Koch, Barbara, et al. "The Mitochondrial GTPase Gem1 Contributes to the Cell Wall Stress Response and Invasive Growth of ." Frontiers in microbiology vol. 8 (2017): 2555. doi: https://doi.org/10.3389/fmicb.2017.02555
Koch B, Tucey TM, Lo TL, Novakovic S, Boag P, Traven A. The Mitochondrial GTPase Gem1 Contributes to the Cell Wall Stress Response and Invasive Growth of . Front Microbiol. 2017 Dec 20;8:2555. doi: 10.3389/fmicb.2017.02555. eCollection 2017. PMID: 29326680; PMCID: PMC5742345.
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Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets.

NPJ vaccines

Music N, Tzeng WP, Liaini Gross F, Levine MZ, Xu X, Shieh WJ, Tumpey TM, Katz JM, York IA.
PMID: 31312528
NPJ Vaccines. 2019 Jul 09;4:28. doi: 10.1038/s41541-019-0123-7. eCollection 2019.

Epidemiological studies suggest that humans who receive repeated annual immunization with influenza vaccine are less well protected against influenza than those who receive vaccine in the current season only. To better understand potential mechanisms underlying these observations, we vaccinated...

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Music N, Tzeng WP, Liaini Gross F, et al. Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets. NPJ Vaccines. 2019;4:28doi: 10.1038/s41541-019-0123-7.
Music, N., Tzeng, W. P., Liaini Gross, F., Levine, M. Z., Xu, X., Shieh, W. J., Tumpey, T. M., Katz, J. M., & York, I. A. (2019). Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets. NPJ vaccines, 428. https://doi.org/10.1038/s41541-019-0123-7
Music, Nedzad, et al. "Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets." NPJ vaccines vol. 4 (2019): 28. doi: https://doi.org/10.1038/s41541-019-0123-7
Music N, Tzeng WP, Liaini Gross F, Levine MZ, Xu X, Shieh WJ, Tumpey TM, Katz JM, York IA. Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets. NPJ Vaccines. 2019 Jul 09;4:28. doi: 10.1038/s41541-019-0123-7. eCollection 2019. PMID: 31312528; PMCID: PMC6616337.
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Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost.

NPJ vaccines

Levine MZ, Holiday C, Jefferson S, Gross FL, Liu F, Li S, Friel D, Boutet P, Innis BL, Mallett CP, Tumpey TM, Stevens J, Katz JM.
PMID: 31149353
NPJ Vaccines. 2019 May 29;4:22. doi: 10.1038/s41541-019-0114-8. eCollection 2019.

Highly pathogenic avian influenza (HPAI) A(H5Nx) viruses continue to pose a pandemic threat. US national vaccine stockpiles are a cornerstone of the influenza pandemic preparedness plans. However, continual genetic and antigenic divergence of A(H5Nx) viruses requires the development of...

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Levine MZ, Holiday C, Jefferson S, et al. Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost. NPJ Vaccines. 2019;4:22doi: 10.1038/s41541-019-0114-8.
Levine, M. Z., Holiday, C., Jefferson, S., Gross, F. L., Liu, F., Li, S., Friel, D., Boutet, P., Innis, B. L., Mallett, C. P., Tumpey, T. M., Stevens, J., & Katz, J. M. (2019). Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost. NPJ vaccines, 422. https://doi.org/10.1038/s41541-019-0114-8
Levine, Min Z, et al. "Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost." NPJ vaccines vol. 4 (2019): 22. doi: https://doi.org/10.1038/s41541-019-0114-8
Levine MZ, Holiday C, Jefferson S, Gross FL, Liu F, Li S, Friel D, Boutet P, Innis BL, Mallett CP, Tumpey TM, Stevens J, Katz JM. Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost. NPJ Vaccines. 2019 May 29;4:22. doi: 10.1038/s41541-019-0114-8. eCollection 2019. PMID: 31149353; PMCID: PMC6541649.
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Inherent heterogeneity of influenza A virus stability following aerosolization.

Applied and environmental microbiology

Belser JA, Pulit-Penaloza JA, Brock N, Creager HM, Gustin KM, Tumpey TM, Maines TR.
PMID: 34985975
Appl Environ Microbiol. 2022 Jan 05;aem0227121. doi: 10.1128/aem.02271-21. Epub 2022 Jan 05.

Efficient human-to-human transmission represents a necessary adaptation for a zoonotic influenza A virus (IAV) to cause a pandemic. As such, many emerging IAVs are characterized for transmissibility phenotypes in mammalian models, with an emphasis on elucidating viral determinants of...

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Belser JA, Pulit-Penaloza JA, Brock N, et al. Inherent heterogeneity of influenza A virus stability following aerosolization. Appl Environ Microbiol. 2022;aem0227121doi: 10.1128/aem.02271-21.
Belser, J. A., Pulit-Penaloza, J. A., Brock, N., Creager, H. M., Gustin, K. M., Tumpey, T. M., & Maines, T. R. (2022). Inherent heterogeneity of influenza A virus stability following aerosolization. Applied and environmental microbiology, aem0227121. https://doi.org/10.1128/aem.02271-21
Belser, Jessica A, et al. "Inherent heterogeneity of influenza A virus stability following aerosolization." Applied and environmental microbiology vol. (2022): aem0227121. doi: https://doi.org/10.1128/aem.02271-21
Belser JA, Pulit-Penaloza JA, Brock N, Creager HM, Gustin KM, Tumpey TM, Maines TR. Inherent heterogeneity of influenza A virus stability following aerosolization. Appl Environ Microbiol. 2022 Jan 05;aem0227121. doi: 10.1128/aem.02271-21. Epub 2022 Jan 05. PMID: 34985975.
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The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals.

mSphere

Tucey TM, Verma-Gaur J, Nguyen J, Hewitt VL, Lo TL, Shingu-Vazquez M, Robertson AA, Hill JR, Pettolino FA, Beddoe T, Cooper MA, Naderer T, Traven A.
PMID: 27303738
mSphere. 2016 May 25;1(3). doi: 10.1128/mSphere.00074-16. eCollection 2016.

The pathogenic yeast Candida albicans escapes macrophages by triggering NLRP3 inflammasome-dependent host cell death (pyroptosis). Pyroptosis is inflammatory and must be tightly regulated by host and microbe, but the mechanism is incompletely defined. We characterized the C. albicans endoplasmic...

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Tucey TM, Verma-Gaur J, Nguyen J, et al. The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals. mSphere. 2016;1(3)doi: 10.1128/mSphere.00074-16.
Tucey, T. M., Verma-Gaur, J., Nguyen, J., Hewitt, V. L., Lo, T. L., Shingu-Vazquez, M., Robertson, A. A., Hill, J. R., Pettolino, F. A., Beddoe, T., Cooper, M. A., Naderer, T., & Traven, A. (2016). The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals. mSphere, 1(3), . https://doi.org/10.1128/mSphere.00074-16
Tucey, Timothy M, et al. "The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals." mSphere vol. 1,3 (2016). doi: https://doi.org/10.1128/mSphere.00074-16
Tucey TM, Verma-Gaur J, Nguyen J, Hewitt VL, Lo TL, Shingu-Vazquez M, Robertson AA, Hill JR, Pettolino FA, Beddoe T, Cooper MA, Naderer T, Traven A. The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals. mSphere. 2016 May 25;1(3). doi: 10.1128/mSphere.00074-16. eCollection 2016. PMID: 27303738; PMCID: PMC4888881.
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Physical Activity and White Matter Hyperintensities: A Systematic Review of Quantitative Studies.

Preventive medicine reports

Torres ER, Strack EF, Fernandez CE, Tumey TA, Hitchcock ME.
PMID: 26046015
Prev Med Rep. 2015;2:319-325. doi: 10.1016/j.pmedr.2015.04.013.

OBJECTIVE: White matter hyperintensities (WMH) are markers of brain white matter injury seen on magnetic resonance imaging. WMH increase with age and are associated with neuropsychiatric disorders. WMH progression can be slowed by controlling vascular risk factors in individuals...

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Torres ER, Strack EF, Fernandez CE, et al. Physical Activity and White Matter Hyperintensities: A Systematic Review of Quantitative Studies. Prev Med Rep. 2015;2:319-325doi: 10.1016/j.pmedr.2015.04.013.
Torres, E. R., Strack, E. F., Fernandez, C. E., Tumey, T. A., & Hitchcock, M. E. (2015). Physical Activity and White Matter Hyperintensities: A Systematic Review of Quantitative Studies. Preventive medicine reports, 2319-325. https://doi.org/10.1016/j.pmedr.2015.04.013
Torres, Elisa R, et al. "Physical Activity and White Matter Hyperintensities: A Systematic Review of Quantitative Studies." Preventive medicine reports vol. 2 (2015): 319-325. doi: https://doi.org/10.1016/j.pmedr.2015.04.013
Torres ER, Strack EF, Fernandez CE, Tumey TA, Hitchcock ME. Physical Activity and White Matter Hyperintensities: A Systematic Review of Quantitative Studies. Prev Med Rep. 2015;2:319-325. doi: 10.1016/j.pmedr.2015.04.013. PMID: 26046015; PMCID: PMC4450803.
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Sowing the Seeds of a Pandemic? Mammalian Pathogenicity and Transmissibility of H1 Variant Influenza Viruses from the Swine Reservoir.

Tropical medicine and infectious disease

Pulit-Penaloza JA, Belser JA, Tumpey TM, Maines TR.
PMID: 30818793
Trop Med Infect Dis. 2019 Feb 27;4(1). doi: 10.3390/tropicalmed4010041.

Emergence of genetically and antigenically diverse strains of influenza to which the human population has no or limited immunity necessitates continuous risk assessments to determine the likelihood of these viruses acquiring adaptations that facilitate sustained human-to-human transmission. As the...

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Pulit-Penaloza JA, Belser JA, Tumpey TM, et al. Sowing the Seeds of a Pandemic? Mammalian Pathogenicity and Transmissibility of H1 Variant Influenza Viruses from the Swine Reservoir. Trop Med Infect Dis. 2019;4(1)doi: 10.3390/tropicalmed4010041.
Pulit-Penaloza, J. A., Belser, J. A., Tumpey, T. M., & Maines, T. R. (2019). Sowing the Seeds of a Pandemic? Mammalian Pathogenicity and Transmissibility of H1 Variant Influenza Viruses from the Swine Reservoir. Tropical medicine and infectious disease, 4(1), . https://doi.org/10.3390/tropicalmed4010041
Pulit-Penaloza, Joanna A, et al. "Sowing the Seeds of a Pandemic? Mammalian Pathogenicity and Transmissibility of H1 Variant Influenza Viruses from the Swine Reservoir." Tropical medicine and infectious disease vol. 4,1 (2019). doi: https://doi.org/10.3390/tropicalmed4010041
Pulit-Penaloza JA, Belser JA, Tumpey TM, Maines TR. Sowing the Seeds of a Pandemic? Mammalian Pathogenicity and Transmissibility of H1 Variant Influenza Viruses from the Swine Reservoir. Trop Med Infect Dis. 2019 Feb 27;4(1). doi: 10.3390/tropicalmed4010041. PMID: 30818793; PMCID: PMC6473686.
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Showing 1 to 10 of 10 entries