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Quaglia F, Mészáros B, Salladini E, et al. DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. Nucleic Acids Res. 2022;50:D480-D487doi: 10.1093/nar/gkab1082.
Quaglia, F., Mészáros, B., Salladini, E., Hatos, A., Pancsa, R., Chemes, L. B., Pajkos, M., Lazar, T., Peña-Díaz, S., Santos, J., Ács, V., Farahi, N., Fichó, E., Aspromonte, M. C., Bassot, C., Chasapi, A., Davey, N. E., Davidović, R., Dobson, L., Elofsson, A., Erdős, G., Gaudet, P., Giglio, M., Glavina, J., Iserte, J., Iglesias, V., Kálmán, Z., Lambrughi, M., Leonardi, E., Longhi, S., Macedo-Ribeiro, S., Maiani, E., Marchetti, J., Marino-Buslje, C., Mészáros, A., Monzon, A. M., Minervini, G., Nadendla, S., Nilsson, J. F., Novotný, M., Ouzounis, C. A., Palopoli, N., Papaleo, E., Pereira, P. J. B., Pozzati, G., Promponas, V. J., Pujols, J., Rocha, A. C. S., Salas, M., Sawicki, L. R., Schad, E., Shenoy, A., Szaniszló, T., Tsirigos, K. D., Veljkovic, N., Parisi, G., Ventura, S., Dosztányi, Z., Tompa, P., Tosatto, S. C. E., & Piovesan, D. (2022). DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. Nucleic acids research, 50D480-D487. https://doi.org/10.1093/nar/gkab1082
Quaglia, Federica, et al. "DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation." Nucleic acids research vol. 50 (2022): D480-D487. doi: https://doi.org/10.1093/nar/gkab1082
Quaglia F, Mészáros B, Salladini E, Hatos A, Pancsa R, Chemes LB, Pajkos M, Lazar T, Peña-Díaz S, Santos J, Ács V, Farahi N, Fichó E, Aspromonte MC, Bassot C, Chasapi A, Davey NE, Davidović R, Dobson L, Elofsson A, Erdős G, Gaudet P, Giglio M, Glavina J, Iserte J, Iglesias V, Kálmán Z, Lambrughi M, Leonardi E, Longhi S, Macedo-Ribeiro S, Maiani E, Marchetti J, Marino-Buslje C, Mészáros A, Monzon AM, Minervini G, Nadendla S, Nilsson JF, Novotný M, Ouzounis CA, Palopoli N, Papaleo E, Pereira PJB, Pozzati G, Promponas VJ, Pujols J, Rocha ACS, Salas M, Sawicki LR, Schad E, Shenoy A, Szaniszló T, Tsirigos KD, Veljkovic N, Parisi G, Ventura S, Dosztányi Z, Tompa P, Tosatto SCE, Piovesan D. DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. Nucleic Acids Res. 2022 Jan 07;50:D480-D487. doi: 10.1093/nar/gkab1082. PMID: 34850135; PMCID: PMC8728214.
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Nucleic Acids Res. 2022 Jan 07;50:D480-D487. doi: 10.1093/nar/gkab1082.

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation.

Nucleic acids research

Federica Quaglia, Bálint Mészáros, Edoardo Salladini, András Hatos, Rita Pancsa, Lucía B Chemes, Mátyás Pajkos, Tamas Lazar, Samuel Peña-Díaz, Jaime Santos, Veronika Ács, Nazanin Farahi, Erzsébet Fichó, Maria Cristina Aspromonte, Claudio Bassot, Anastasia Chasapi, Norman E Davey, Radoslav Davidović, Laszlo Dobson, Arne Elofsson, Gábor Erdős, Pascale Gaudet, Michelle Giglio, Juliana Glavina, Javier Iserte, Valentín Iglesias, Zsófia Kálmán, Matteo Lambrughi, Emanuela Leonardi, Sonia Longhi, Sandra Macedo-Ribeiro, Emiliano Maiani, Julia Marchetti, Cristina Marino-Buslje, Attila Mészáros, Alexander Miguel Monzon, Giovanni Minervini, Suvarna Nadendla, Juliet F Nilsson, Marian Novotný, Christos A Ouzounis, Nicolás Palopoli, Elena Papaleo, Pedro José Barbosa Pereira, Gabriele Pozzati, Vasilis J Promponas, Jordi Pujols, Alma Carolina Sanchez Rocha, Martin Salas, Luciana Rodriguez Sawicki, Eva Schad, Aditi Shenoy, Tamás Szaniszló, Konstantinos D Tsirigos, Nevena Veljkovic, Gustavo Parisi, Salvador Ventura, Zsuzsanna Dosztányi, Peter Tompa, Silvio C E Tosatto, Damiano Piovesan

Affiliations

  1. Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM), Bari, Italy.
  2. Department of Biomedical Sciences, University of Padova, Padova, Italy.
  3. Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.
  4. Institute of Enzymology, Research Centre for Natural Sciences, Budapest 1117, Hungary.
  5. Instituto de Investigaciones Biotecnológicas (IIBiO-CONICET), Universidad Nacional de San Martín, Av. 25 de Mayo y Francia, CP1650 Buenos Aires, Argentina.
  6. Department of Biochemistry, Eötvös Loránd University, Pázmány Péter stny 1/c, Budapest H-1117, Hungary.
  7. VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnology, Brussels, Belgium.
  8. Structural Biology Brussels (SBB), Bioengineering Sciences Department, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  9. Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
  10. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain.
  11. Cytocast Kft., Vecsés, Hungary.
  12. Department of Woman and Child Health, University of Padova, Padova, Italy.
  13. Pediatric Research Institute, Città della Speranza, Padova, Italy.
  14. Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 171 21 Solna, Sweden.
  15. Biological Computation & Process Laboratory, Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, Thermi, Thessalonica 57001, Greece.
  16. Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd, Chelsea, London, UK.
  17. Laboratory for Bioinformatics and Computational Chemistry, Vin?a Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000Belgrade, Serbia.
  18. Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland.
  19. Institute for Genome Sciences, University of Maryland School of Medicine 670 W. Baltimore St., Baltimore, MD 21201, USA.
  20. Bioinformatics Unit, Fundación Instituto Leloir, Buenos Aires, C1405BWE, Argentina.
  21. Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50/A, 1083 Budapest, Hungary.
  22. Cancer Structural Biology, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark.
  23. Lab. Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Aix Marseille University and Centre National de la Recherche Scientifique (CNRS), 163 Avenue de Luminy, Case 932, 13288, Marseille, France.
  24. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4200-135 Porto, Portugal.
  25. Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, 4200-135 Porto, Portugal.
  26. Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina.
  27. Dep. of Cell Biology, Faculty of Science, Vinicna 7, 128 43, Prague, Czech Republic.
  28. Biological Computation & Computational Biology Group, Artificial Intelligence & Information Analysis Lab, Department of Computer Science, Aristotle University of Thessalonica, Thessalonica 54124, Greece.
  29. Cancer Systems Biology, Section for Bioinformatics, Department of Health and Technology, Technical University of Denmark, Lyngby, Denmark.
  30. Bioinformatics Research Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus.
  31. Department of Cell Biology, Faculty of Science, Charles University, BIOCEV, Prague , Czech Republic.
  32. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.
  33. ICREA, Barcelona, Spain.

PMID: 34850135 PMCID: PMC8728214 DOI: 10.1093/nar/gkab1082

Abstract

The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

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