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Li S, Shi S, Luo B, et al. Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea. Exp Eye Res. 2021;215:108900doi: 10.1016/j.exer.2021.108900.
Li, S., Shi, S., Luo, B., Xia, F., Ha, Y., Merkley, K. H., Motamedi, M., Zhang, W., & Liu, H. (2021). Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea. Experimental eye research, 215108900. https://doi.org/10.1016/j.exer.2021.108900
Li, Shengguo, et al. "Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea." Experimental eye research vol. 215 (2021): 108900. doi: https://doi.org/10.1016/j.exer.2021.108900
Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H. Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea. Exp Eye Res. 2021 Dec 18;215:108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 18. PMID: 34929160.
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Exp Eye Res. 2021 Dec 18;215:108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 18.

Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea.

Experimental eye research

Shengguo Li, Shuizhen Shi, Ban Luo, Fan Xia, Yonju Ha, Kevin H Merkley, Massoud Motamedi, Wenbo Zhang, Hua Liu

Affiliations

  1. Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China; Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, TX, USA.
  2. Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, TX, USA.
  3. Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, TX, USA; Departments of Neuroscience, Cell Biology & Anatomy, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: [email protected].
  4. Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: [email protected].

PMID: 34929160 DOI: 10.1016/j.exer.2021.108900

Abstract

The cornea is transparent and innervated by a dense collection of sensory nerves originating from the ocular branch of the trigeminal nerve. This study was designed to comprehensively analyze alterations of corneal sub-basal nerve plexus in a mouse model of tauopathy (P301L transgenic mice) to test the possibility of using corneal nerves as a biomarker for tauopathy. Corneal sensitivity, thickness and epithelial wound healing were measured non-invasively by aeshesiometer, optical coherence tomography and fluorescein staining, respectively. Tau, corneal nerves and immune cells were examined by immunohistochemistry or Western blot. At the early stage of tauopathy, although corneal sensitivity, thickness and nerve fiber density were not greatly altered, corneal nerve abnormalities were observed in the peripheral region of young P301L mice. With aging, the density of abnormal nerves increased, while corneal sensitivity, epithelial thickness, nerve fiber density and length decreased in middle-aged P301L mice compared with WT mice. After corneal epithelial injury in young mice, no difference in reepithelialization was observed between two groups of mice, however, the regeneration of corneal nerves in P301L mice lagged behind WT mice, which was reflected by delayed recovery of corneal sensitivity, decreased corneal nerve density and length and density of CD45

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Keywords: Cornea; Nerve degeneration; Nerve regeneration; Tauopathy; Wound healing

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