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Nocentini A, Bonardi A, Pratesi S, et al. Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin. J Enzyme Inhib Med Chem. 2022;37(1):487-501doi: 10.1080/14756366.2021.2020773.
Nocentini, A., Bonardi, A., Pratesi, S., Gratteri, P., Dani, C., & Supuran, C. T. (2022). Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin. Journal of enzyme inhibition and medicinal chemistry, 37(1), 487-501. https://doi.org/10.1080/14756366.2021.2020773
Nocentini, Alessio, et al. "Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin." Journal of enzyme inhibition and medicinal chemistry vol. 37,1 (2022): 487-501. doi: https://doi.org/10.1080/14756366.2021.2020773
Nocentini A, Bonardi A, Pratesi S, Gratteri P, Dani C, Supuran CT. Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin. J Enzyme Inhib Med Chem. 2022 Dec;37(1):487-501. doi: 10.1080/14756366.2021.2020773. PMID: 34986721; PMCID: PMC8741241.
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J Enzyme Inhib Med Chem. 2022 Dec;37(1):487-501. doi: 10.1080/14756366.2021.2020773.

Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin.

Journal of enzyme inhibition and medicinal chemistry

Alessio Nocentini, Alessandro Bonardi, Simone Pratesi, Paola Gratteri, Carlo Dani, Claudiu T Supuran

Affiliations

  1. Department of Neurosciences, Psychology, Drug Research and Child Health, Pharmaceutical and Nutraceutical Section, University of Florence, Florence, Italy.
  2. Department of Neurosciences, Psychology, Drug Research and Child Health, Careggi University, Hospital of Florence, Florence, Italy.
  3. Department of Neurosciences, Psychology, Drug Research and Child Health, Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modelling Cheminformatics & QSAR, University of Florence, Florence, Italy.

PMID: 34986721 PMCID: PMC8741241 DOI: 10.1080/14756366.2021.2020773

Abstract

Bilirubin (BR) is the final product of haem catabolism. Disruptions along BR metabolic/transport pathways resulting from inherited disorders can increase plasma BR concentration (hyperbilirubinaemia). Unconjugated hyperbilirubinemia may induce BR accumulation in brain, potentially causing irreversible neurological damage, a condition known as BR encephalopathy or kernicterus, to which newborns are especially vulnerable. Numerous pharmaceutical strategies, mostly based on hemoperfusion, have been proposed over the last decades to identify new valid, low-risk alternatives for BR removal from plasma. On the other hand, accumulating evidence indicates that BR produces health benefits due to its potent antioxidant, anti-inflammatory and immunomodulatory action with a significant potential for the treatment of a multitude of diseases. The present manuscript reviews both such aspects of BR pharmacology, gathering literature data on applied pharmaceutical strategies adopted to: (i) reduce the plasma BR concentration for preventing neurotoxicity; (ii) produce a therapeutic effect based on BR efficacy in the treatment of many disorders.

Keywords: Bilirubin; antioxidant; hyperbilirubinaemia; jaundice

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