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Raindi D, Rees J, Hirschfeld J, et al. Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees. Arch Oral Biol. 2021;134:105342doi: 10.1016/j.archoralbio.2021.105342.
Raindi, D., Rees, J., Hirschfeld, J., Wright, H., Dobbs, P., Moittié, S., White, K., Stahl, W., Martin, M., Redrobe, S., Hughes, F., Liptovszky, M., Baiker, K., & Grant, M. (2021). Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees. Archives of oral biology, 134105342. https://doi.org/10.1016/j.archoralbio.2021.105342
Raindi, Devan, et al. "Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees." Archives of oral biology vol. 134 (2021): 105342. doi: https://doi.org/10.1016/j.archoralbio.2021.105342
Raindi D, Rees J, Hirschfeld J, Wright H, Dobbs P, Moittié S, White K, Stahl W, Martin M, Redrobe S, Hughes F, Liptovszky M, Baiker K, Grant M. Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees. Arch Oral Biol. 2021 Dec 16;134:105342. doi: 10.1016/j.archoralbio.2021.105342. Epub 2021 Dec 16. PMID: 34942432.
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Arch Oral Biol. 2021 Dec 16;134:105342. doi: 10.1016/j.archoralbio.2021.105342. Epub 2021 Dec 16.

Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees.

Archives of oral biology

Devan Raindi, Jacqueline Rees, Josefine Hirschfeld, Helen Wright, Phillipa Dobbs, Sophie Moittié, Kate White, Wilhelm Stahl, Mike Martin, Sharon Redrobe, Francis Hughes, Matyas Liptovszky, Kerstin Baiker, Melissa Grant

Affiliations

  1. School of Dentistry, Institute of Clinical Sciences, University of Birmingham and Birmingham Dental Hospital, 5 Mill Pool Way, Edgbaston, Birmingham B5 7EG, UK.
  2. Veterinary Department, Twycross Zoo, East Midland Zoological Society, Burton road, Atherstone CV9 3PX, UK.
  3. Veterinary Department, Twycross Zoo, East Midland Zoological Society, Burton road, Atherstone CV9 3PX, UK; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD, UK.
  4. School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD, UK.
  5. Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich Heine University Düsseldorf, D-40001 Düsseldorf, Germany.
  6. Veterinary Cardiology Consultancy, Kenilworth, Warwickshire. UK.
  7. Kings College London, Guy's Tower, Guy's Hospital, Great Maze Pond, London SE1 1UL, UK.
  8. Veterinary Department, Twycross Zoo, East Midland Zoological Society, Burton road, Atherstone CV9 3PX, UK; Life Sciences Division, Perth Zoo, 20 Labouchere road, South Perth 6051, WA, Australia.
  9. School of Dentistry, Institute of Clinical Sciences, University of Birmingham and Birmingham Dental Hospital, 5 Mill Pool Way, Edgbaston, Birmingham B5 7EG, UK. Electronic address: [email protected].

PMID: 34942432 DOI: 10.1016/j.archoralbio.2021.105342

Abstract

OBJECTIVE: To investigate the association of dental and cardiac disease in a cohort of captive chimpanzees DESIGN: 12 captive chimpanzees underwent periodontal and cardiac examinations under anaesthesia during a relocation to a new enclosure. Blood samples were taken for analysis of circulating markers of cardiac health, nutritional status and isolation of neutrophils for functional assays. They were then observed for three years for signs of heart disease.

RESULTS: Although the chimpanzees displayed large quantities of supragingival plaque, they had low bleeding scores. Peripheral blood neutrophils responded to innate and adaptive immune stimuli. In the follow up period two animals died and post mortem confirmed heart disease. Levels of NT-proBNP were found to be high in chimpanzees that died from heart disease.

CONCLUSIONS: Whilst there appeared to be a correlation between probing depth and age, there appeared to be no correlation between dental data and heart data in this cohort.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Cardiac health; Chimpanzee; Periodontitis

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