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Mahajnah M, Suchi AT, Zahakah H, et al. Multidomain Cognitive Impairment in Children With Pseudotumor Cerebri Syndrome. J Neuroophthalmol. 2022;doi: 10.1097/WNO.0000000000001420.
Mahajnah, M., Suchi, A. T., Zahakah, H., Sharkia, R., Shuhaiber, S. R., Srugo, I., & Genizi, J. (2022). Multidomain Cognitive Impairment in Children With Pseudotumor Cerebri Syndrome. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, . https://doi.org/10.1097/WNO.0000000000001420
Mahajnah, Muhammad, et al. "Multidomain Cognitive Impairment in Children With Pseudotumor Cerebri Syndrome." Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society vol. (2022). doi: https://doi.org/10.1097/WNO.0000000000001420
Mahajnah M, Suchi AT, Zahakah H, Sharkia R, Shuhaiber SR, Srugo I, Genizi J. Multidomain Cognitive Impairment in Children With Pseudotumor Cerebri Syndrome. J Neuroophthalmol. 2022 Jan 04; doi: 10.1097/WNO.0000000000001420. Epub 2022 Jan 04. PMID: 34999654.
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J Neuroophthalmol. 2022 Jan 04; doi: 10.1097/WNO.0000000000001420. Epub 2022 Jan 04.

Multidomain Cognitive Impairment in Children With Pseudotumor Cerebri Syndrome.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

Muhammad Mahajnah, Ariel T Suchi, Hazar Zahakah, Rajech Sharkia, Shaden R Shuhaiber, Isaac Srugo, Jacob Genizi

Affiliations

  1. Child Neurology and Development Center (MM, ATS, HZ, SSR), Hillel-Yaffe Medical Center, Hadera, Israel; Child Neurology Unit (JG), Bnai-Zion Medical Center, Haifa, Israel; Pediatric Department (IS, JG), Bnai-Zion Medical Center, Haifa, Israel; The Ruth and Bruce Rappaport Faculty of Medicine (MM, IS, JG), Technion, Haifa, Israel; The Triangle Regional Research and Development Center (RS), Kfar Qara, Israel; and Beit Berl Academic College (RS), Israel.

PMID: 34999654 DOI: 10.1097/WNO.0000000000001420

Abstract

BACKGROUND: Although prompt and suitable treatment of pseudotumor cerebri syndrome (PTCS) leads to an excellent prognosis and can prevent optic nerve atrophy, adults show long-lasting neurocognitive deficits even with prompt treatment. The purpose of our study was to evaluate cognitive outcomes in pediatric patients with PTCS.

METHODS: We performed a prospective study on children diagnosed with PTCS and a healthy control group. Children with pre-existing neurological conditions or psychiatric drug use were excluded. Both groups underwent a neurocognitive evaluation, using the NeuroTrax computerized battery of tests. The PTCS group were tested 3 months after the initial diagnosis.

RESULTS: We evaluated 82 children (49 females [60%], 6.5-16 years old, mean age 13.3), including 26 diagnosed with idiopathic PTC and 56 controls. Global cognitive score (P < 0.001), verbal memory (P < 0.001), executive function (P < 0.001), attention (P< 0.003), and information processing speed (P < 0.004) were all significantly lower in the PTCS group. No differences were found between children currently being treated and those whose symptoms had resolved and treatment was stopped.

CONCLUSIONS: Children with PTCS experience comprehensive cognitive decline that persists after the resolution of the symptoms and treatment.

Copyright © 2022 by North American Neuro-Ophthalmology Society.

Conflict of interest statement

The authors report no conflicts of interest.

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