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Luu BR, Nance RM, Delaney JAC, et al. Insomnia and Risk of Myocardial Infarction Among People with HIV. J Acquir Immune Defic Syndr. 2022;doi: 10.1097/QAI.0000000000002910.
Luu, B. R., Nance, R. M., Delaney, J. A. C., Ruderman, S. A., Heckbert, S. R., Budoff, M. J., Mathews, W. C., Moore, R. D., Feinstein, M. J., Burkholder, G. A., Eron, J. J., Mugavero, M. J., Saag, M. S., Kitahata, M. M., Crane, H. M., & Whitney, B. M. (2022). Insomnia and Risk of Myocardial Infarction Among People with HIV. Journal of acquired immune deficiency syndromes (1999), . https://doi.org/10.1097/QAI.0000000000002910
Luu, Brandon R, et al. "Insomnia and Risk of Myocardial Infarction Among People with HIV." Journal of acquired immune deficiency syndromes (1999) vol. (2022). doi: https://doi.org/10.1097/QAI.0000000000002910
Luu BR, Nance RM, Delaney JAC, Ruderman SA, Heckbert SR, Budoff MJ, Mathews WC, Moore RD, Feinstein MJ, Burkholder GA, Eron JJ, Mugavero MJ, Saag MS, Kitahata MM, Crane HM, Whitney BM. Insomnia and Risk of Myocardial Infarction Among People with HIV. J Acquir Immune Defic Syndr. 2022 Jan 06; doi: 10.1097/QAI.0000000000002910. Epub 2022 Jan 06. PMID: 35001042.
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J Acquir Immune Defic Syndr. 2022 Jan 06; doi: 10.1097/QAI.0000000000002910. Epub 2022 Jan 06.

Insomnia and Risk of Myocardial Infarction Among People with HIV.

Journal of acquired immune deficiency syndromes (1999)

Brandon R Luu, Robin M Nance, Joseph A C Delaney, Stephanie A Ruderman, Susan R Heckbert, Matthew J Budoff, William C Mathews, Richard D Moore, Matthew J Feinstein, Greer A Burkholder, Joseph J Eron, Michael J Mugavero, Michael S Saag, Mari M Kitahata, Heidi M Crane, Bridget M Whitney

Affiliations

  1. Northern Ontario School of Medicine, Thunder Bay, ON, Canada University of Washington, Seattle, WA, USA University of Manitoba, Winnipeg, MB, Canada University of California Los Angeles, Los Angeles, CA, USA University of California San Diego, San Diego, CA, USA Johns Hopkins University, Baltimore, MD, USA Northwestern University, Chicago, IL, USA University of Alabama at Birmingham, Birmingham, AL, USA University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

PMID: 35001042 DOI: 10.1097/QAI.0000000000002910

Abstract

BACKGROUND: Insomnia is common among people with HIV (PWH) and may be associated with increased risk of myocardial infarction (MI). This study examines the association between insomnia and MI by MI type among PWH.

SETTING: Longitudinal cohort study of PWH at five Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) sites.

METHODS: Clinical data and patient-reported measures and outcomes (PROs) from PWH in care between 2005-2018 were utilized in this study. Insomnia, measured at baseline, was defined as having difficulty falling or staying asleep with bothersome symptoms. CNICS centrally adjudicates MIs using expert reviewers, with distinction between type 1 (T1MI) and type 2 MIs (T2MI). Associations between insomnia and first incident MI by MI type were measured using separate Cox proportional hazard models adjusted for age, sex, race/ethnicity, traditional cardiovascular disease risk factors (hypertension, dyslipidemia, poor kidney function, diabetes, smoking), HIV markers (antiretroviral therapy, viral suppression, CD4 cell count), and stimulant use (cocaine/crack, methamphetamine).

RESULTS: Among 12,448 PWH, 48% reported insomnia. Over a median of 4.4 years of follow-up, 158 T1MIs and 109 T2MIs were identified; approximately half of T2MIs were attributed to sepsis or stimulant use. After adjustment for potential confounders, we found no association between insomnia and T1MI (HR=1.05, 95%CI:0.76-1.45) and a 65% increased risk of T2MI among PWH reporting insomnia compared to PWH without insomnia (HR=1.65, 95%CI:1.11-2.45).

CONCLUSIONS: PWH reporting insomnia are at an increased risk of T2MI, but not T1MI, compared to PWH without insomnia, highlighting the importance of distinguishing MI types among PWH.

Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Conflict of interest statement

Conflicts of interest and source of funding: The authors report no potential conflicts of interest, including relevant financial interests, activities, relationships, and affiliations. This work was s

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