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Shams S, Martinez JM, Dawson JRD, et al. The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions. Front Pharmacol. 2021;12:680043doi: 10.3389/fphar.2021.680043.
Shams, S., Martinez, J. M., Dawson, J. R. D., Flores, J., Gabriel, M., Garcia, G., Guevara, A., Murray, K., Pacifici, N., Vargas, M. V., Voelker, T., Hell, J. W., & Ashouri, J. F. (2021). The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions. Frontiers in pharmacology, 12680043. https://doi.org/10.3389/fphar.2021.680043
Shams, Shahin, et al. "The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions." Frontiers in pharmacology vol. 12 (2021): 680043. doi: https://doi.org/10.3389/fphar.2021.680043
Shams S, Martinez JM, Dawson JRD, Flores J, Gabriel M, Garcia G, Guevara A, Murray K, Pacifici N, Vargas MV, Voelker T, Hell JW, Ashouri JF. The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions. Front Pharmacol. 2021 May 28;12:680043. doi: 10.3389/fphar.2021.680043. eCollection 2021. PMID: 34122106; PMCID: PMC8194305.
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Front Pharmacol. 2021 May 28;12:680043. doi: 10.3389/fphar.2021.680043. eCollection 2021.

The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions.

Frontiers in pharmacology

Shahin Shams, Joseph M Martinez, John R D Dawson, Juan Flores, Marina Gabriel, Gustavo Garcia, Amanda Guevara, Kaitlin Murray, Noah Pacifici, Maxemiliano V Vargas, Taylor Voelker, Johannes W Hell, Judith F Ashouri

Affiliations

  1. Department of Biomedical Engineering, University of California, Davis, Davis, CA, United States.
  2. Department of Pharmacology, University of California, Davis, Davis, CA, United States.
  3. Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, United States.
  4. Center for Neuroscience, University of California, Davis, Davis, CA, United States.
  5. Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, Davis, CA, United States.
  6. Department of Chemistry, University of California, Davis, Davis, CA, United States.
  7. Rosalind Russell and Ephraim R. Engleman Rheumatology Research Center, Department of Medicine, University of California, San Francisco, CA, United States.

PMID: 34122106 PMCID: PMC8194305 DOI: 10.3389/fphar.2021.680043

Abstract

Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many patients with RA continue to have inadequate response to therapies, or intolerable side effects, with resultant progression of their disease. In this review, we detail multiple biomolecular pathways involved in RA disease pathogenesis to elucidate and highlight pathways that have been therapeutic targets in managing this systemic autoimmune disease. Here we present an up-to-date accounting of both emerging and approved pharmacological treatments for RA, detailing their discovery, mechanisms of action, efficacy, and limitations. Finally, we turn to the emerging fields of bioengineering and cell therapy to illuminate possible future targeted therapeutic options that combine material and biological sciences for localized therapeutic action with the potential to greatly reduce side effects seen in systemically applied treatment modalities.

Copyright © 2021 Shams, Martinez, Dawson, Flores, Gabriel, Garcia, Guevara, Murray, Pacifici, Vargas, Voelker, Hell and Ashouri.

Keywords: JAK-STAT signaling; adenosine receptor; autoimmune disease; biological therapies; disease modifying anti-rheumatic drugs; inflammatory cytokines and chemokines; nanoparticles; rheumatoid arthritis

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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