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Oteng AB, Higuchi S, Banks AS, et al. Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage. Mol Metab. 2021;53:101326doi: 10.1016/j.molmet.2021.101326.
Oteng, A. B., Higuchi, S., Banks, A. S., & Haeusler, R. A. (2021). Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage. Molecular metabolism, 53101326. https://doi.org/10.1016/j.molmet.2021.101326
Oteng, Antwi-Boasiako, et al. "Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage." Molecular metabolism vol. 53 (2021): 101326. doi: https://doi.org/10.1016/j.molmet.2021.101326
Oteng AB, Higuchi S, Banks AS, Haeusler RA. Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage. Mol Metab. 2021 Nov;53:101326. doi: 10.1016/j.molmet.2021.101326. Epub 2021 Aug 24. PMID: 34438105; PMCID: PMC8449133.
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Mol Metab. 2021 Nov;53:101326. doi: 10.1016/j.molmet.2021.101326. Epub 2021 Aug 24.

Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage.

Molecular metabolism

Antwi-Boasiako Oteng, Sei Higuchi, Alexander S Banks, Rebecca A Haeusler

Affiliations

  1. Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, NY, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  2. Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
  3. Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, NY, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA. Electronic address: [email protected].

PMID: 34438105 PMCID: PMC8449133 DOI: 10.1016/j.molmet.2021.101326

Abstract

OBJECTIVE: Murine-specific muricholic acids (MCAs) are reported to protect against obesity and associated metabolic disorders. However, the response of mice with genetic depletion of MCA to an obesogenic diet has not been evaluated. We used Cyp2c-deficient (Cyp2c

METHODS: Male and female Cyp2c

RESULTS: Cyp2c-deficiency depleted MCAs and caused other changes in BA composition, namely a decrease in the ratio of 12α-hydroxylated (12α-OH) BAs to non-12α-OH BAs, without altering the total BA levels. While WT male mice became obese after HFD feeding, Cyp2c

CONCLUSIONS: MCA does not protect against diet-induced obesity but may protect against liver injury. Reduced lipid absorption in Cyp2c-deficient male mice is potentially due to a reduced ratio of 12α-OH/non-12α-OH BAs.

Copyright © 2021 The Author(s). Published by Elsevier GmbH.. All rights reserved.

Keywords: Bile acid; Glucose homeostasis; Lipid absorption; Liver fibrosis; Muricholic acid; Obesity

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