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Rice MT, von Borstel A, Chevour P, et al. Recognition of the antigen-presenting molecule MR1 by a Vδ3. Proc Natl Acad Sci U S A. 2021;118(49)doi: 10.1073/pnas.2110288118.
Rice, M. T., von Borstel, A., Chevour, P., Awad, W., Howson, L. J., Littler, D. R., Gherardin, N. A., Le Nours, J., Giles, E. M., Berry, R., Godfrey, D. I., Davey, M. S., Rossjohn, J., & Gully, B. S. (2021). Recognition of the antigen-presenting molecule MR1 by a Vδ3. Proceedings of the National Academy of Sciences of the United States of America, 118(49), . https://doi.org/10.1073/pnas.2110288118
Rice, Michael T, et al. "Recognition of the antigen-presenting molecule MR1 by a Vδ3." Proceedings of the National Academy of Sciences of the United States of America vol. 118,49 (2021). doi: https://doi.org/10.1073/pnas.2110288118
Rice MT, von Borstel A, Chevour P, Awad W, Howson LJ, Littler DR, Gherardin NA, Le Nours J, Giles EM, Berry R, Godfrey DI, Davey MS, Rossjohn J, Gully BS. Recognition of the antigen-presenting molecule MR1 by a Vδ3. Proc Natl Acad Sci U S A. 2021 Dec 07;118(49). doi: 10.1073/pnas.2110288118. PMID: 34845016; PMCID: PMC8694053.
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Proc Natl Acad Sci U S A. 2021 Dec 07;118(49). doi: 10.1073/pnas.2110288118.

Recognition of the antigen-presenting molecule MR1 by a Vδ3.

Proceedings of the National Academy of Sciences of the United States of America

Michael T Rice, Anouk von Borstel, Priyanka Chevour, Wael Awad, Lauren J Howson, Dene R Littler, Nicholas A Gherardin, Jérôme Le Nours, Edward M Giles, Richard Berry, Dale I Godfrey, Martin S Davey, Jamie Rossjohn, Benjamin S Gully

Affiliations

  1. Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
  2. Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
  3. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.
  4. Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.
  5. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC 3010, Australia.
  6. Department of Paediatrics, Monash University, Clayton, VIC 3168, Australia.
  7. Centre for Innate Immunity and Infectious Disease, Hudson Institute of Medicine, Clayton, VIC 3168, Australia.
  8. Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; [email protected] [email protected] [email protected].
  9. Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.

PMID: 34845016 PMCID: PMC8694053 DOI: 10.1073/pnas.2110288118

Abstract

Unlike conventional αβ T cells, γδ T cells typically recognize nonpeptide ligands independently of major histocompatibility complex (MHC) restriction. Accordingly, the γδ T cell receptor (TCR) can potentially recognize a wide array of ligands; however, few ligands have been described to date. While there is a growing appreciation of the molecular bases underpinning variable (V)δ1

Keywords: MR1; structural immunology; γδTCR

Conflict of interest statement

Competing interest statement: J.R. is an inventor on patents describing MR1 tetramers and MR1 ligands.

References

  1. Science. 2005 Apr 8;308(5719):227-31 - PubMed
  2. Immunity. 2016 Jan 19;44(1):32-45 - PubMed
  3. J Synchrotron Radiat. 2002 Nov 1;9(Pt 6):401-6 - PubMed
  4. J Exp Med. 1990 May 1;171(5):1597-612 - PubMed
  5. Nat Immunol. 2020 Apr;21(4):400-411 - PubMed
  6. Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501 - PubMed
  7. Nat Commun. 2017 Mar 01;8:14760 - PubMed
  8. Nature. 2014 May 15;509(7500):361-5 - PubMed
  9. Cell Mol Immunol. 2013 Jan;10(1):50-7 - PubMed
  10. Eur J Immunol. 1991 Apr;21(4):1053-9 - PubMed
  11. Nat Immunol. 2016 May;17(5):531-7 - PubMed
  12. Scand J Immunol. 1989 Jul;30(1):123-8 - PubMed
  13. Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):235-42 - PubMed
  14. J Exp Med. 2000 Sep 4;192(5):741-54 - PubMed
  15. Nature. 1998 Jan 29;391(6666):502-6 - PubMed
  16. Methods. 2011 Sep;55(1):94-106 - PubMed
  17. J Exp Med. 2008 May 12;205(5):1201-11 - PubMed
  18. Clin Exp Immunol. 1994 Oct;98(1):78-82 - PubMed
  19. PLoS One. 2013 Oct 04;8(10):e76008 - PubMed
  20. Mediators Inflamm. 1999;8(6):305-12 - PubMed
  21. Eur J Immunol. 1993 Apr;23(4):804-8 - PubMed
  22. Nat Commun. 2019 May 21;10(1):2243 - PubMed
  23. Blood. 2011 Jul 28;118(4):992-1001 - PubMed
  24. J Immunol. 1994 Nov 1;153(9):3979-88 - PubMed
  25. Nat Immunol. 2010 Aug;11(8):701-8 - PubMed
  26. Nat Immunol. 2012 Sep;13(9):872-9 - PubMed
  27. J Exp Med. 1991 Jun 1;173(6):1311-22 - PubMed
  28. Science. 1998 Mar 13;279(5357):1737-40 - PubMed
  29. Immunology. 2009 Feb;126(2):147-64 - PubMed
  30. J Clin Invest. 1999 May 15;103(10):1437-49 - PubMed
  31. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E556-65 - PubMed
  32. J Exp Med. 2013 Oct 21;210(11):2305-20 - PubMed
  33. Nat Immunol. 2013 Nov;14(11):1137-45 - PubMed
  34. Nat Rev Immunol. 2015 Nov;15(11):683-91 - PubMed
  35. Mediators Inflamm. 2001 Aug;10(4):179-89 - PubMed
  36. J Immunol. 2013 Jul 1;191(1):30-4 - PubMed
  37. Immunol Rev. 2007 Feb;215:59-76 - PubMed
  38. Nat Commun. 2018 Nov 9;9(1):4706 - PubMed
  39. Nat Immunol. 2017 Apr;18(4):402-411 - PubMed
  40. Immunity. 2014 Apr 17;40(4):490-500 - PubMed
  41. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3163-3168 - PubMed
  42. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22944-22952 - PubMed
  43. Blood. 2012 Apr 26;119(17):4013-6 - PubMed
  44. Science. 2020 Feb 7;367(6478): - PubMed
  45. Science. 2019 Dec 20;366(6472):1522-1527 - PubMed
  46. Nat Commun. 2013;4:2142 - PubMed
  47. Nat Commun. 2018 May 2;9(1):1760 - PubMed
  48. Biochem Soc Trans. 2021 Nov 1;49(5):1985-1995 - PubMed
  49. J Exp Med. 2014 Jul 28;211(8):1585-600 - PubMed
  50. Genome Res. 2004 Jun;14(6):1188-90 - PubMed
  51. Nature. 2012 Nov 29;491(7426):717-23 - PubMed
  52. Blood. 2011 Dec 22;118(26):6952-62 - PubMed
  53. Immunity. 2013 Dec 12;39(6):1032-42 - PubMed
  54. Immunity. 2012 Sep 21;37(3):524-34 - PubMed
  55. Nat Immunol. 2020 Feb;21(2):178-185 - PubMed
  56. Sci Immunol. 2018 Dec 14;3(30): - PubMed
  57. Nat Commun. 2014 May 15;5:3866 - PubMed
  58. J Invest Dermatol. 1990 Jan;94(1):37-42 - PubMed
  59. Trends Immunol. 2018 Jun;39(6):446-459 - PubMed
  60. J Biol Chem. 2020 Oct 16;295(42):14445-14457 - PubMed
  61. Int Immunol. 1999 Apr;11(4):545-52 - PubMed
  62. Nat Rev Immunol. 2013 Feb;13(2):88-100 - PubMed
  63. J Immunol. 2015 Mar 1;194(5):2390-8 - PubMed
  64. PLoS Biol. 2010 Jun 29;8(6):e1000407 - PubMed
  65. J Immunol. 2016 Feb 15;196(4):1933-42 - PubMed
  66. Blood. 2012 Sep 13;120(11):2269-79 - PubMed
  67. Nat Immunol. 2018 Apr;19(4):397-406 - PubMed
  68. Eur J Immunol. 2012 Sep;42(9):2505-10 - PubMed
  69. Nat Immunol. 2015 Mar;16(3):258-66 - PubMed

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