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Li C, Li J, Loreno EG, et al. Protective Effect of Low-Dose Alcohol Consumption against Post-Ischemic Neuronal Apoptosis: Role of L-PGDS. Int J Mol Sci. 2021;23(1)doi: 10.3390/ijms23010133.
Li, C., Li, J., Loreno, E. G., Miriyala, S., Panchatcharam, M., & Sun, H. (2021). Protective Effect of Low-Dose Alcohol Consumption against Post-Ischemic Neuronal Apoptosis: Role of L-PGDS. International journal of molecular sciences, 23(1), . https://doi.org/10.3390/ijms23010133
Li, Chun, et al. "Protective Effect of Low-Dose Alcohol Consumption against Post-Ischemic Neuronal Apoptosis: Role of L-PGDS." International journal of molecular sciences vol. 23,1 (2021). doi: https://doi.org/10.3390/ijms23010133
Li C, Li J, Loreno EG, Miriyala S, Panchatcharam M, Sun H. Protective Effect of Low-Dose Alcohol Consumption against Post-Ischemic Neuronal Apoptosis: Role of L-PGDS. Int J Mol Sci. 2021 Dec 23;23(1). doi: 10.3390/ijms23010133. PMID: 35008575.
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Int J Mol Sci. 2021 Dec 23;23(1). doi: 10.3390/ijms23010133.

Protective Effect of Low-Dose Alcohol Consumption against Post-Ischemic Neuronal Apoptosis: Role of L-PGDS.

International journal of molecular sciences

Chun Li, Jiyu Li, Ethyn G Loreno, Sumitra Miriyala, Manikandan Panchatcharam, Hong Sun

Affiliations

  1. Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA.

PMID: 35008575 DOI: 10.3390/ijms23010133

Abstract

Ischemic stroke is one of the leading causes of permanent disability and death in adults worldwide. Apoptosis is a major element contributing to post-ischemic neuronal death. We previously found that low-dose alcohol consumption (LAC) protects against neuronal apoptosis in the peri-infarct cortex following transient focal cerebral ischemia. Lipocalin-type prostaglandin D2 synthase (L-PGDS), which is mainly localized in the central nervous system (CNS), was previously shown to inhibit neuronal apoptosis. Therefore, we determined whether L-PGDS is involved in the protective effect of LAC against post-ischemic neuronal apoptosis. Wild-type (WT), CaMKIIα

Keywords: L-PGDS; apoptosis; brain; ethanol; ischemic stroke

Publication Types

Grant support