Display options
Share it on

Int J Mol Sci. 2021 Dec 21;23(1). doi: 10.3390/ijms23010042.

High-Dose Benzodiazepines Positively Modulate GABA.

International journal of molecular sciences

Na Wang, Jingjing Lian, Yanqing Cao, Alai Muheyati, Shanshan Yuan, Yujie Ma, Shuzhuo Zhang, Gang Yu, Ruibin Su

Affiliations

  1. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

PMID: 35008465 PMCID: PMC8744940 DOI: 10.3390/ijms23010042

Abstract

Benzodiazepines (BZDs) produce versatile pharmacological actions through positive modulation of GABA

Keywords: GABAA receptors; benzodiazepine; loss of righting reflex; non-classical binding site; voltage-clamp electrophysiology

References

  1. J Med Toxicol. 2013 Jun;9(2):155-62 - PubMed
  2. Eur Neuropsychopharmacol. 1999 Jan;9(1-2):45-50 - PubMed
  3. Neuropharmacology. 2005 Sep;49(3):425-9 - PubMed
  4. Anesthesiology. 2020 Sep;133(3):583-594 - PubMed
  5. Brain Sci. 2020 Mar 05;10(3): - PubMed
  6. Trends Pharmacol Sci. 2018 Jul;39(7):659-671 - PubMed
  7. Biochem Biophys Res Commun. 2017 Aug 26;490(3):1125-1131 - PubMed
  8. Psychopharmacology (Berl). 1982;78(1):8-18 - PubMed
  9. Neuropharmacology. 2015 Aug;95:459-67 - PubMed
  10. Life Sci. 2019 Dec 15;239:117033 - PubMed
  11. Nat Rev Neurosci. 2005 Mar;6(3):215-29 - PubMed
  12. Sci Rep. 2017 Nov 14;7(1):15498 - PubMed
  13. Sci Rep. 2016 May 20;6:25943 - PubMed
  14. Br J Pharmacol. 2012 Feb;165(4):965-77 - PubMed
  15. Nature. 2019 Jan;565(7740):454-459 - PubMed
  16. Adv Pharmacol. 2015;72:53-96 - PubMed
  17. Nat Rev Drug Discov. 2011 Jul 29;10(9):685-97 - PubMed
  18. Br J Anaesth. 1972 Aug;44(8):803-8 - PubMed
  19. Sci Rep. 2016 Jun 27;6:28674 - PubMed
  20. Adv Pharmacol. 2017;79:1-34 - PubMed
  21. Nature. 2020 Sep;585(7824):303-308 - PubMed
  22. Nat Neurosci. 2000 Dec;3(12):1274-81 - PubMed
  23. Curr Top Med Chem. 2002 Aug;2(8):795-816 - PubMed
  24. Anesthesiology. 2011 Dec;115(6):1338-48 - PubMed
  25. J Neurosci. 2011 Jan 19;31(3):870-7 - PubMed
  26. Neuropharmacology. 2018 Jul 1;136(Pt A):10-22 - PubMed
  27. J Pharmacol Exp Ther. 1988 Mar;244(3):912-8 - PubMed
  28. FEBS Lett. 2006 Mar 6;580(6):1616-20 - PubMed
  29. Nat Rev Neurosci. 2008 May;9(5):331-43 - PubMed
  30. J Neurochem. 2008 Sep;106(6):2353-63 - PubMed
  31. Anesth Analg. 2010 Dec;111(6):1394-9 - PubMed
  32. Nature. 2018 Jul;559(7712):67-72 - PubMed
  33. Br J Pharmacol. 2021 Dec;178(24):4842-4858 - PubMed

Publication Types