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Vedhara K, Ayling K, Jia R, et al. Relationship between Anxiety, Depression and Susceptibility to SARS-CoV-2 Infection: Proof of Concept. J Infect Dis. 2022;doi: 10.1093/infdis/jiac006.
Vedhara, K., Ayling, K., Jia, R., Fairclough, L., Morling, J. R., Ball, J. K., Knight, H., Blake, H., Corner, J., Denning, C., Bolton, K., Jackson, H., Coupland, C., & Tighe, P. (2022). Relationship between Anxiety, Depression and Susceptibility to SARS-CoV-2 Infection: Proof of Concept. The Journal of infectious diseases, . https://doi.org/10.1093/infdis/jiac006
Vedhara, Kavita, et al. "Relationship between Anxiety, Depression and Susceptibility to SARS-CoV-2 Infection: Proof of Concept." The Journal of infectious diseases vol. (2022). doi: https://doi.org/10.1093/infdis/jiac006
Vedhara K, Ayling K, Jia R, Fairclough L, Morling JR, Ball JK, Knight H, Blake H, Corner J, Denning C, Bolton K, Jackson H, Coupland C, Tighe P. Relationship between Anxiety, Depression and Susceptibility to SARS-CoV-2 Infection: Proof of Concept. J Infect Dis. 2022 Jan 12; doi: 10.1093/infdis/jiac006. Epub 2022 Jan 12. PMID: 35022740.
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J Infect Dis. 2022 Jan 12; doi: 10.1093/infdis/jiac006. Epub 2022 Jan 12.

Relationship between Anxiety, Depression and Susceptibility to SARS-CoV-2 Infection: Proof of Concept.

The Journal of infectious diseases

Kavita Vedhara, Kieran Ayling, Ru Jia, Lucy Fairclough, Joanne R Morling, Jonathan K Ball, Holly Knight, Holly Blake, Jessica Corner, Chris Denning, Kirsty Bolton, Hannah Jackson, Carol Coupland, Patrick Tighe

Affiliations

  1. School of Medicine, University of Nottingham, UK.
  2. School of Life Sciences, University of Nottingham, UK.
  3. NIHR Nottingham Biomedical Research Centre, University of Nottingham, UK.
  4. Biodiscovery Institute, University of Nottingham, UK.
  5. School of Health Sciences, University of Nottingham, UK.
  6. University Executive Board, University of Nottingham, UK.
  7. School of Mathematical Sciences, University of Nottingham, UK.

PMID: 35022740 DOI: 10.1093/infdis/jiac006

Abstract

Psychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in SARS-CoV-2 infection. Participants (n=102) completed measures of anxiety, depression, positive mood and loneliness and provided a blood sample for the measurement of antibodies to the SARS-CoV-2 spike and nucleocapsid proteins. SARS-CoV-2 seropositivity was significantly associated with anxiety and significantly positively associated with depression. The model remained significant after adjustment for age and gender, although anxiety and depression were no longer significant independent predictors. These findings offer early support for the hypothesis that psychological factors may influence susceptibility to SARS-CoV-2 infection.

© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Keywords: COVID-19; SARS-CoV-2; antibodies; anxiety; depression; seropositivity

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