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Wang Y, Wang L, Wang X, et al. Inflammatory Injury and Mitophagy in the Cock Heart Induced by the Oral Administration of Hexavalent Chromium. Biol Trace Elem Res. 2021;200(3):1312-1320doi: 10.1007/s12011-021-02715-0.
Wang, Y., Wang, L., Wang, X., Cheng, G., Xing, Y., Zhang, M., Zhang, P., & Liu, J. (2022). Inflammatory Injury and Mitophagy in the Cock Heart Induced by the Oral Administration of Hexavalent Chromium. Biological trace element research, 200(3), 1312-1320. https://doi.org/10.1007/s12011-021-02715-0
Wang, Yue, et al. "Inflammatory Injury and Mitophagy in the Cock Heart Induced by the Oral Administration of Hexavalent Chromium." Biological trace element research vol. 200,3 (2022): 1312-1320. doi: https://doi.org/10.1007/s12011-021-02715-0
Wang Y, Wang L, Wang X, Cheng G, Xing Y, Zhang M, Zhang P, Liu J. Inflammatory Injury and Mitophagy in the Cock Heart Induced by the Oral Administration of Hexavalent Chromium. Biol Trace Elem Res. 2022 Mar;200(3):1312-1320. doi: 10.1007/s12011-021-02715-0. Epub 2021 Apr 13. PMID: 33851329.
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Biol Trace Elem Res. 2022 Mar;200(3):1312-1320. doi: 10.1007/s12011-021-02715-0. Epub 2021 Apr 13.

Inflammatory Injury and Mitophagy in the Cock Heart Induced by the Oral Administration of Hexavalent Chromium.

Biological trace element research

Yue Wang, Lumei Wang, Xiaozhou Wang, Guodong Cheng, Yuxiao Xing, Meihua Zhang, Pu Zhang, Jianzhu Liu

Affiliations

  1. College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.
  2. College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, Shandong, China.
  3. Central Hospital of Tai'an City, Tai'an, 271018, Shandong, China. [email protected].
  4. College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, Shandong, China. [email protected].

PMID: 33851329 DOI: 10.1007/s12011-021-02715-0

Abstract

As a highly toxic heavy metal, chromium has caused a certain threat to public health and livestock breeding in recent years. In poultry, as one of our most commonly consumed meat product, its health issues will seriously threaten the safety of human life. As previous studies have confirmed, when cells are stimulated by the external environment, mitochondria, as an organelle that provides energy to the cells, can cause damage and autophagy. The purpose of this study is to confirm whether Cr(VI) can cause mitophagy in cock heart. We first randomly divided 32 cocks into four groups to explore the mechanism of this effect. The cocks were then separately exposed to four different dose levels, namely, the control level and 10, 30, and 50 mg/kg levels, via daily oral intake into the body through mixed feeding for 45 days. After 45 days, we sampled and detected pathological changes and the levels of inflammatory factors (IL-6, TNF-α, and IFN-γ), mitochondrial membrane potential (MMP), adenosine triphosphatases (ATPases), and mitophagy-related proteins (LC3, p62/SQTM1, TOMM20, and Parkin). We found that IL-6, TNF-α, IFN-γ, and LC3II contents increased with the increase in Cr(VI) concentration. However, MMP, ATPases, p62/SQTM1, and TOMM20 levels decreased with the increase in Cr(VI) concentration. At the same time, Cr(VI) exposure caused heart tissue damages and Parkin translocation. In conclusion, our results proved that inflammatory damage, mitochondrial function damage, and mitophagy in cock heart tissues were dependent on Cr(VI) concentration.

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords: Cock; Cr(VI); Heart; Inflammatory injury; Mitophagy

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