Display options
Cite
Ho AFW, Lim MJR, Zheng H, et al. Association of ambient air pollution with risk of hemorrhagic stroke: A time-stratified case crossover analysis of the Singapore stroke registry. Int J Hyg Environ Health. 2021;240:113908doi: 10.1016/j.ijheh.2021.113908.
Ho, A. F. W., Lim, M. J. R., Zheng, H., Leow, A. S., Tan, B. Y., Pek, P. P., Raju, Y., Seow, W. J., Yeo, T. T., Sharma, V. K., Aik, J., & Ong, M. E. H. (2021). Association of ambient air pollution with risk of hemorrhagic stroke: A time-stratified case crossover analysis of the Singapore stroke registry. International journal of hygiene and environmental health, 240113908. https://doi.org/10.1016/j.ijheh.2021.113908
Ho, Andrew Fu Wah, et al. "Association of ambient air pollution with risk of hemorrhagic stroke: A time-stratified case crossover analysis of the Singapore stroke registry." International journal of hygiene and environmental health vol. 240 (2021): 113908. doi: https://doi.org/10.1016/j.ijheh.2021.113908
Ho AFW, Lim MJR, Zheng H, Leow AS, Tan BY, Pek PP, Raju Y, Seow WJ, Yeo TT, Sharma VK, Aik J, Ong MEH. Association of ambient air pollution with risk of hemorrhagic stroke: A time-stratified case crossover analysis of the Singapore stroke registry. Int J Hyg Environ Health. 2021 Dec 30;240:113908. doi: 10.1016/j.ijheh.2021.113908. Epub 2021 Dec 30. PMID: 34974273.
Copy Download .nbib Format: NLM
Share it on

Int J Hyg Environ Health. 2021 Dec 30;240:113908. doi: 10.1016/j.ijheh.2021.113908. Epub 2021 Dec 30.

Association of ambient air pollution with risk of hemorrhagic stroke: A time-stratified case crossover analysis of the Singapore stroke registry.

International journal of hygiene and environmental health

Andrew Fu Wah Ho, Mervyn Jun Rui Lim, Huili Zheng, Aloysius Sheng-Ting Leow, Benjamin Yong-Qiang Tan, Pin Pin Pek, Yogeswari Raju, Wei-Jie Seow, Tseng Tsai Yeo, Vijay K Sharma, Joel Aik, Marcus Eng Hock Ong

Affiliations

  1. Department of Emergency Medicine, Singapore General Hospital, Singapore; Pre-hospital and Emergency Research Centre, Health Services and Systems Research, Duke-NUS Medical School, Singapore. Electronic address: [email protected].
  2. Division of Neurosurgery, Department of Surgery, National University Hospital, Singapore.
  3. Division of Neurology, Department of Medicine, National University Health System, Singapore.
  4. Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  5. Pre-hospital and Emergency Research Centre, Health Services and Systems Research, Duke-NUS Medical School, Singapore.
  6. Environmental Quality Monitoring Department, Environmental Monitoring and Modelling Division, National Environment Agency, Singapore.
  7. National Registry of Diseases Office, Health Promotion Board, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
  8. Division of Neurology, Department of Medicine, National University Health System, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  9. Pre-hospital and Emergency Research Centre, Health Services and Systems Research, Duke-NUS Medical School, Singapore; Environmental Epidemiology and Toxicology Division, National Environment Agency, Singapore.
  10. Department of Emergency Medicine, Singapore General Hospital, Singapore; Pre-hospital and Emergency Research Centre, Health Services and Systems Research, Duke-NUS Medical School, Singapore.

PMID: 34974273 DOI: 10.1016/j.ijheh.2021.113908

Abstract

BACKGROUND: Haemorrhagic stroke (HS) is a major cause of mortality and disability. Previous studies reported inconsistent associations between ambient air pollutants and HS risk.

OBJECTIVE: We evaluated the association between air pollutant exposure and the risk of HS in a cosmopolitan city in the tropics.

METHODS: We performed a nationwide, population-based, time-stratified case-crossover analysis on all HS cases reported to the Singapore Stroke Registry from 2009 to 2018 (n = 12,636). We estimated the risk of HS across tertiles of air pollutant concentrations in conditional Poisson models, adjusting for meteorological confounders. We stratified our analysis by age, atrial fibrillation and smoking status, and investigated the lagged effects of each pollutant on the risk of HS up to 5 days.

RESULTS: All 12,636 episodes of HS were included. The median (1st-to 3rd-quartile) daily pollutant levels from 22 remote stations deployed across the island were as follows: (PM

CONCLUSION: Short-term exposure to ambient CO levels was associated with an increased risk of HS. A reduction in CO emissions may reduce the burden of HS in the population.

Copyright © 2021 Elsevier GmbH. All rights reserved.

Keywords: Air pollution; Epidemiology; Haze; Hemorrhagic stroke

Publication Types