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Wu Y, Jia H, Zhou H, et al. Immune and stromal related genes in colon cancer: Analysis of tumour microenvironment based on the cancer genome atlas (TCGA) and gene expression omnibus (GEO) databases. Scand J Immunol. 2021;95(2):e13119doi: 10.1111/sji.13119.
Wu, Y., Jia, H., Zhou, H., Liu, X., Sun, J., Zhou, X., & Zhao, H. (2022). Immune and stromal related genes in colon cancer: Analysis of tumour microenvironment based on the cancer genome atlas (TCGA) and gene expression omnibus (GEO) databases. Scandinavian journal of immunology, 95(2), e13119. https://doi.org/10.1111/sji.13119
Wu, Yue, et al. "Immune and stromal related genes in colon cancer: Analysis of tumour microenvironment based on the cancer genome atlas (TCGA) and gene expression omnibus (GEO) databases." Scandinavian journal of immunology vol. 95,2 (2022): e13119. doi: https://doi.org/10.1111/sji.13119
Wu Y, Jia H, Zhou H, Liu X, Sun J, Zhou X, Zhao H. Immune and stromal related genes in colon cancer: Analysis of tumour microenvironment based on the cancer genome atlas (TCGA) and gene expression omnibus (GEO) databases. Scand J Immunol. 2022 Feb;95(2):e13119. doi: 10.1111/sji.13119. Epub 2021 Dec 26. PMID: 34796980.
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Scand J Immunol. 2022 Feb;95(2):e13119. doi: 10.1111/sji.13119. Epub 2021 Dec 26.

Immune and stromal related genes in colon cancer: Analysis of tumour microenvironment based on the cancer genome atlas (TCGA) and gene expression omnibus (GEO) databases.

Scandinavian journal of immunology

Yue Wu, Haowei Jia, Hangyuan Zhou, Xinyu Liu, Junfeng Sun, Xiaoyan Zhou, Hongchao Zhao

Affiliations

  1. Department of Gastrointestinal Surgery, The First affiliated hospital of Zhengzhou University, Zhengzhou, China.
  2. Pharmacy Intravenous Admixture Services, The First affiliated hospital of Zhengzhou University, Zhengzhou, China.

PMID: 34796980 DOI: 10.1111/sji.13119

Abstract

The incidence of colon cancer is amongst the top three in the world. The tumour microenvironment plays an important role in the occurrence and development of colon cancer. Stromal cells and immune cells are the main components of the tumour microenvironment. Our study detected genes, which affected the infiltration of stromal, immune cells and the way they affected the prognosis of colon cancer patients. We found that the colon's immune system had a special way to affect the tumour microenvironment. Moderate infiltration of stromal and immune cells was proved to be important protective factors for colon cancer patients, which has not been found in other tumours. C3, C5, CXCL12, GNAI1, LPAR1, PENK, PYY, SAA1 and SST were the differential expression hub genes of moderate-stromal and immune score group. They had a more significant correlation with tumour purity and infiltration of B cells, CD8

© 2021 The Scandinavian Foundation for Immunology.

Keywords: ESTIMATE algorithm; colon cancer; database; immune infiltration; prognosis; tumour microenvironment

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