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Shen Y, Laue HE, Shrubsole MJ, et al. Associations of Childhood and Perinatal Blood Metals with Children's Gut Microbiomes in a Canadian Gestation Cohort. Environ Health Perspect. 2022;130(1):17007doi: 10.1289/EHP9674.
Shen, Y., Laue, H. E., Shrubsole, M. J., Wu, H., Bloomquist, T. R., Larouche, A., Zhao, K., Gao, F., Boivin, A., Prada, D., Hunting, D. J., Gillet, V., Takser, L., & Baccarelli, A. A. (2022). Associations of Childhood and Perinatal Blood Metals with Children's Gut Microbiomes in a Canadian Gestation Cohort. Environmental health perspectives, 130(1), 17007. https://doi.org/10.1289/EHP9674
Shen, Yike, et al. "Associations of Childhood and Perinatal Blood Metals with Children's Gut Microbiomes in a Canadian Gestation Cohort." Environmental health perspectives vol. 130,1 (2022): 17007. doi: https://doi.org/10.1289/EHP9674
Shen Y, Laue HE, Shrubsole MJ, Wu H, Bloomquist TR, Larouche A, Zhao K, Gao F, Boivin A, Prada D, Hunting DJ, Gillet V, Takser L, Baccarelli AA. Associations of Childhood and Perinatal Blood Metals with Children's Gut Microbiomes in a Canadian Gestation Cohort. Environ Health Perspect. 2022 Jan;130(1):17007. doi: 10.1289/EHP9674. Epub 2022 Jan 17. PMID: 35037767.
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Environ Health Perspect. 2022 Jan;130(1):17007. doi: 10.1289/EHP9674. Epub 2022 Jan 17.

Associations of Childhood and Perinatal Blood Metals with Children's Gut Microbiomes in a Canadian Gestation Cohort.

Environmental health perspectives

Yike Shen, Hannah E Laue, Martha J Shrubsole, Haotian Wu, Tessa R Bloomquist, Annie Larouche, Kankan Zhao, Feng Gao, Amélie Boivin, Diddier Prada, Darel J Hunting, Virginie Gillet, Larissa Takser, Andrea A Baccarelli

Affiliations

  1. Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.
  2. Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
  3. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  4. Département de Pédiatrie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.
  5. Institute of Soil and Water Resources and Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
  6. Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
  7. Department of Basic Science, Instituto Nacional de Cancerologia, Ciudad de México, México.
  8. Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Sherbrooke, Québec, Canada.
  9. Departement de Psychiatrie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.

PMID: 35037767 DOI: 10.1289/EHP9674

Abstract

BACKGROUND: The gut microbiome is important in modulating health in childhood. Metal exposures affect multiple health outcomes, but their ability to modify bacterial communities in children is poorly understood.

OBJECTIVES: We assessed the associations of childhood and perinatal blood metal levels with childhood gut microbiome diversity, structure, species, gene family-inferred species, and potential pathway alterations.

METHODS: We assessed the gut microbiome using 16S rRNA gene amplicon sequencing and shotgun metagenomic sequencing in stools collected from 6- to 7-year-old children participating in the GESTation and Environment (GESTE) cohort study. We assessed blood metal concentrations [cadmium (Cd), manganese (Mn), mercury (Hg), lead (Pb), selenium (Se)] at two time points, namely, perinatal exposures at delivery (

RESULTS: Children's blood Mn and Se significantly associated with microbiome phylum [e.g., Verrucomicrobiota (

DISCUSSION: Our findings suggest both long- and short-term associations between metal exposure and the childhood gut microbiome, with stronger associations observed with more recent exposure. Future epidemiologic analyses may elucidate whether the observed changes in the microbiome relate to children's health. https://doi.org/10.1289/EHP9674.

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