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Xie Z, Wei L, Chen J, et al. Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury. Bioengineered. 2022;13(2):2816-2826doi: 10.1080/21655979.2021.2024394.
Xie, Z., Wei, L., Chen, J., & Chen, Z. (2022). Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury. Bioengineered, 13(2), 2816-2826. https://doi.org/10.1080/21655979.2021.2024394
Xie, Zhijuan, et al. "Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury." Bioengineered vol. 13,2 (2022): 2816-2826. doi: https://doi.org/10.1080/21655979.2021.2024394
Xie Z, Wei L, Chen J, Chen Z. Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury. Bioengineered. 2022 Feb;13(2):2816-2826. doi: 10.1080/21655979.2021.2024394. PMID: 35038964.
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Bioengineered. 2022 Feb;13(2):2816-2826. doi: 10.1080/21655979.2021.2024394.

Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury.

Bioengineered

Zhijuan Xie, Lanji Wei, Jianying Chen, Zhong Chen

Affiliations

  1. Department of Nephrology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
  2. Department of Health Management Center, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
  3. Department of Rheumatology and Immunology, Hunan Provincial People's Hospital, Changsha, Hunan, China.
  4. Department of Nuclear Medicine, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

PMID: 35038964 DOI: 10.1080/21655979.2021.2024394

Abstract

Acute kidney injury (AKI) is a serious complication of sepsis that increases mortality and the risk of progression to chronic kidney disease. Oxidative stress and apoptosis are reported to exert critical function in the pathogenesis of sepsis-associated AKI. Calcium dobesilate (CaD) was reported to play a protective role in renal diseases. Therefore, we explored the antioxidant effect and potential mechanism of CaD in lipopolysaccharide (LPS)-induced AKI in mice. We evaluated renal function (blood urea nitrogen (BUN) and serum creatinine (SCr)), histopathology, oxidative stress (superoxide dismutase (SOD) and malondialdehyde (MDA)), inflammation cytokines, and apoptosis in kidneys of mice. The effect of CaD on NF-κB signaling was evaluated by Western blot. Our findings showed that CaD alleviated renal dysfunction and kidney injury, and also reversed upregulated MDA concentration and reduced SOD enzyme activity in AKI mice. Moreover, LPS-induced inflammatory response was attenuated by CaD. CaD treatment also reduced the apoptosis evoked by LPS. Additionally, CaD downregulated phosphorylation of nuclear factor kappa B (NF-κB) signaling components in LPS mice. Conclusively, CaD alleviates renal dysfunction and inflammation by targeting NF-κB signaling in sepsis-associated AKI.

Keywords: Calcium dobesilate; NF-κB signaling; acute kidney injury; sepsis

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