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Lunardi A, Gaboli M, Giorgio M, et al. A Role for PML in Innate Immunity. Genes Cancer. 2011;2(1):10-9doi: 10.1177/1947601911402682.
Lunardi, A., Gaboli, M., Giorgio, M., Rivi, R., Bygrave, A., Antoniou, M., Drabek, D., Dzierzak, E., Fagioli, M., Salmena, L., Botto, M., Cordon-Cardo, C., Luzzatto, L., Pelicci, P. G., Grosveld, F., & Pandolfi, P. P. (2011). A Role for PML in Innate Immunity. Genes & cancer, 2(1), 10-9. https://doi.org/10.1177/1947601911402682
Lunardi, Andrea, et al. "A Role for PML in Innate Immunity." Genes & cancer vol. 2,1 (2011): 10-9. doi: https://doi.org/10.1177/1947601911402682
Lunardi A, Gaboli M, Giorgio M, Rivi R, Bygrave A, Antoniou M, Drabek D, Dzierzak E, Fagioli M, Salmena L, Botto M, Cordon-Cardo C, Luzzatto L, Pelicci PG, Grosveld F, Pandolfi PP. A Role for PML in Innate Immunity. Genes Cancer. 2011 Jan;2(1):10-9. doi: 10.1177/1947601911402682. PMID: 21779477; PMCID: PMC3111006.
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Genes Cancer. 2011 Jan;2(1):10-9. doi: 10.1177/1947601911402682.

A Role for PML in Innate Immunity.

Genes & cancer

Andrea Lunardi, Mirella Gaboli, Marco Giorgio, Roberta Rivi, Anne Bygrave, Michael Antoniou, Dubravka Drabek, Elaine Dzierzak, Marta Fagioli, Leonardo Salmena, Marina Botto, Carlos Cordon-Cardo, Lucio Luzzatto, Pier Giuseppe Pelicci, Frank Grosveld, Pier Paolo Pandolfi

Affiliations

  1. Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

PMID: 21779477 PMCID: PMC3111006 DOI: 10.1177/1947601911402682

Abstract

The promyelocytic leukemia gene (PML) of acute promyelocytic leukemia is an established tumor suppressor gene with critical functions in growth suppression, induction of apoptosis, and cellular senescence. Interestingly, although less studied, PML seems to play a key role also in immune response to viral infection. Herein, we report that Pml(-/-) mice spontaneously develop an atypical invasive and lethal granulomatous lesion known as botryomycosis (BTM). In Pml(-/-) mice, BTM is the result of impaired function of macrophages, whereby they fail to become activated and are thus unable to clear pathogenic microorganisms. Accordingly, Pml(-/-) mice are resistant to lipopolysaccharide (LPS)-induced septic shock as a result of an ineffective production of cytokines and chemokines, suggesting a role for PML in the innate immune Toll-like receptor (TLR)/NF-κB prosurvival pathway. These results not only shed light on a new fundamental function of PML in innate immunity, but they also point to a proto-oncogenic role for PML in certain cellular and pathological contexts.

Keywords: PML; botryomycosis; innate immunity

References

  1. Cancer Cell. 2009 Aug 4;16(2):91-102 - PubMed
  2. Nat Neurosci. 2009 Feb;12(2):132-40 - PubMed
  3. Am J Med. 1970 Sep;49(3):322-7 - PubMed
  4. Oncogene. 2008 Oct 20;27(48):6299-312 - PubMed
  5. Nature. 2006 Aug 17;442(7104):779-85 - PubMed
  6. Curr Opin Genet Dev. 2008 Feb;18(1):19-26 - PubMed
  7. Mol Cell Biol. 1998 Feb;18(2):1084-93 - PubMed
  8. Mol Cell. 2006 Nov 3;24(3):331-9 - PubMed
  9. FASEB J. 2007 Nov;21(13):3763-70 - PubMed
  10. Blood. 2009 Apr 2;113(14):3139-46 - PubMed
  11. Biochimie. 2007 Jun-Jul;89(6-7):819-30 - PubMed
  12. J Clin Oncol. 2009 Jul 20;27(21):3437-44 - PubMed
  13. Clin Microbiol Rev. 1993 Jan;6(1):34-56 - PubMed
  14. Blood. 1995 Apr 1;85(7):1871-80 - PubMed
  15. Cell. 2004 Aug 6;118(3):285-96 - PubMed
  16. Sci Signal. 2010 Sep 07;3(138):pe29 - PubMed
  17. Immunol Rev. 1987 Jun;97:5-27 - PubMed
  18. Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a000141 - PubMed
  19. J Interferon Cytokine Res. 2011 Jan;31(1):145-58 - PubMed
  20. Immunobiology. 1994 Oct;191(4-5):509-19 - PubMed
  21. Cell. 2009 Nov 13;139(4):693-706 - PubMed
  22. Cell. 2002 Jan 25;108(2):165-70 - PubMed
  23. Blood. 1990 May 15;75(10):1920-3 - PubMed
  24. Cell. 2007 Jan 12;128(1):141-56 - PubMed
  25. Cell. 2006 Feb 24;124(4):823-35 - PubMed
  26. Cutis. 1995 Mar;55(3):149-52 - PubMed
  27. Leukemia. 2005 May;19(5):841-6 - PubMed
  28. Nat Rev Mol Cell Biol. 2007 Dec;8(12):1006-16 - PubMed
  29. Annu Rev Med. 1992;43:117-24 - PubMed
  30. Nature. 2006 May 25;441(7092):523-7 - PubMed
  31. Cell. 2006 Jul 28;126(2):269-83 - PubMed
  32. Nat Genet. 1995 Feb;9(2):202-9 - PubMed
  33. Biochem J. 2009 Jul 29;422(1):1-10 - PubMed
  34. Nature. 2004 Sep 9;431(7005):205-11 - PubMed
  35. Science. 1998 Mar 6;279(5356):1547-51 - PubMed
  36. J Immunol. 1988 Oct 1;141(7):2407-12 - PubMed
  37. Nature. 2008 Jun 19;453(7198):1072-8 - PubMed
  38. Nat Cell Biol. 2004 Jul;6(7):665-72 - PubMed
  39. Nat Rev Microbiol. 2005 Oct;3(10):799-808 - PubMed
  40. Cell. 1995 Jan 27;80(2):353-61 - PubMed
  41. Mol Cell Biol. 2010 Apr;30(8):2046-56 - PubMed
  42. J Natl Cancer Inst. 2004 Feb 18;96(4):269-79 - PubMed
  43. Nature. 2004 Sep 23;431(7007):461-6 - PubMed
  44. Nature. 1988 Mar 3;332(6159):83-5 - PubMed

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