Display options
Cite
Yalcin AD, Bisgin A, Erbay RH, et al. Trimetazidine effect on burn-induced intestinal mucosal injury and kidney damage in rats. Int J Burns Trauma. 2012;2(2):110-7
Yalcin, A. D., Bisgin, A., Erbay, R. H., Oguz, O., Demir, S., Yilmaz, M., & Gumuslu, S. (2012). Trimetazidine effect on burn-induced intestinal mucosal injury and kidney damage in rats. International journal of burns and trauma, 2(2), 110-7.
Yalcin, Arzu Didem, et al. "Trimetazidine effect on burn-induced intestinal mucosal injury and kidney damage in rats." International journal of burns and trauma vol. 2,2 (2012): 110-7.
Yalcin AD, Bisgin A, Erbay RH, Oguz O, Demir S, Yilmaz M, Gumuslu S. Trimetazidine effect on burn-induced intestinal mucosal injury and kidney damage in rats. Int J Burns Trauma. 2012;2(2):110-7. Epub 2012 Sep 15. PMID: 23071909; PMCID: PMC3462527.
Copy Download .nbib Format: NLM
Share it on

Int J Burns Trauma. 2012;2(2):110-7. Epub 2012 Sep 15.

Trimetazidine effect on burn-induced intestinal mucosal injury and kidney damage in rats.

International journal of burns and trauma

Arzu Didem Yalcin, Atil Bisgin, Riza Hakan Erbay, Oguzhan Oguz, Suleyman Demir, Mustafa Yilmaz, Saadet Gumuslu

Affiliations

  1. Allergy and Clinical Immunology Unit, Antalya Education and Training Hospital Antalya, Turkey.

PMID: 23071909 PMCID: PMC3462527

Abstract

BACKGROUND: Trimetazidine (TMZ) has been used in cardiology practice for protection from ischemiareperfusion injury. But its effects on intestinal mucosa are not well known. Our aim was to investigate the protective effect of TMZ on intestinal mucosa and on damaged kidney due to thermal injury in rats.

MATERIAL AND METHODS: Total of 30 male Sprague-Dawley rats were used in the study of intestinal mucosa damage and 24 female Sprague-Dawley rats in renal injury model. Back regions were shaved and taken into 99°C water for about 10 seconds in order to have a thermal injury. All rats were sacrificed 5 hours after the burn injury. Tissue malondialdehyde (MDA), myeloperoxidase (MPO) and glutathione (GSH) levels were measured. In order to show the tissue edema resulting from microvascular circulatory impairment, unbiased stereological technique, Cavalieri's volume estimation applied to each kidney.

RESULT: TMZ decreased MPO levels, but no effect on GSH/oxidized glutathione (GSSG) and MDA levels. MPO levels were significantly lower in TMZ group than burnt-control group (p<0.05). There were statistically significant differences in the kidney volumes between TMZ group and sham group (p<0.05).

CONCLUSION: In this study, TMZ seems to be protective on intestinal mucosa and prevented kidney damage originated from thermal injury.

Keywords: Cavalieri's volume estimation; Oxidative stress; intestinal and kidney damage; thermal injury; trimetazidine

References

  1. Am J Cardiol. 1995 Aug 24;76(6):25B-30B - PubMed
  2. Chem Pharm Bull (Tokyo). 1981 Oct;29(10):2910-4 - PubMed
  3. Crit Care Med. 1993 Feb;21(2 Suppl):S92-102 - PubMed
  4. Anal Biochem. 1979 Jun;95(2):351-8 - PubMed
  5. J Immunol. 1992 Sep 1;149(5):1723-8 - PubMed
  6. J Trauma. 1975 Aug;15(8):697-703 - PubMed
  7. World J Surg. 1992 Jan-Feb;16(1):30-6 - PubMed
  8. Gastroenterology. 1994 Mar;106(3):629-36 - PubMed
  9. Mol Cell Biochem. 1993 Jul 7;124(1):59-66 - PubMed
  10. J Trauma. 1986 Nov;26(11):995-8 - PubMed
  11. J Trauma. 1983 Feb;23(2):102-5 - PubMed
  12. Cardiovasc Drugs Ther. 1988 Mar;1(6):677-86 - PubMed
  13. Science. 1982 Jul 9;217(4555):121-9 - PubMed
  14. Burns Incl Therm Inj. 1987 Apr;13(2):103-9 - PubMed
  15. N Engl J Med. 1985 Nov 28;313(22):1389-98 - PubMed
  16. Arch Surg. 1988 Dec;123(12):1519-24 - PubMed
  17. Acta Physiol Scand. 1985 Aug;124(4):581-9 - PubMed
  18. Am J Surg. 1987 Dec;154(6):623-7 - PubMed
  19. Br J Clin Pharmacol. 1985 Aug;20(2):148-51 - PubMed
  20. Am J Physiol. 1984 Aug;247(2 Pt 1):G167-70 - PubMed
  21. Ann Surg. 1992 Dec;216(6):677-83 - PubMed
  22. J Burn Care Rehabil. 1986 Nov-Dec;7(6):469-74 - PubMed
  23. Am J Surg. 1993 Nov;166(5):557-62 - PubMed
  24. Surgery. 1987 Nov;102(5):808-12 - PubMed
  25. Burns. 1997 Mar;23(2):114-6 - PubMed
  26. Biochem Pharmacol. 2002 May 1;63(9):1691-7 - PubMed
  27. Surgery. 1983 Feb;93(2):289-96 - PubMed
  28. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
  29. Surgery. 1989 May;105(5):593-7 - PubMed
  30. Am J Pathol. 1965 Apr;46:589-620 - PubMed

Publication Types