Display options
Cite
Dyson RM, Palliser HK, Lakkundi A, et al. Early microvascular changes in the preterm neonate: a comparative study of the human and guinea pig. Physiol Rep. 2014;2(9)doi: 10.14814/phy2.12145.
Dyson, R. M., Palliser, H. K., Lakkundi, A., de Waal, K., Latter, J. L., Clifton, V. L., & Wright, I. M. (2014). Early microvascular changes in the preterm neonate: a comparative study of the human and guinea pig. Physiological reports, 2(9), . https://doi.org/10.14814/phy2.12145
Dyson, Rebecca M, et al. "Early microvascular changes in the preterm neonate: a comparative study of the human and guinea pig." Physiological reports vol. 2,9 (2014). doi: https://doi.org/10.14814/phy2.12145
Dyson RM, Palliser HK, Lakkundi A, de Waal K, Latter JL, Clifton VL, Wright IM. Early microvascular changes in the preterm neonate: a comparative study of the human and guinea pig. Physiol Rep. 2014 Sep 17;2(9). doi: 10.14814/phy2.12145. PMID: 25350751; PMCID: PMC4270232.
Copy Download .nbib Format: NLM
Share it on

Physiol Rep. 2014 Sep 17;2(9). doi: 10.14814/phy2.12145.

Early microvascular changes in the preterm neonate: a comparative study of the human and guinea pig.

Physiological reports

Rebecca M Dyson, Hannah K Palliser, Anil Lakkundi, Koert de Waal, Joanna L Latter, Vicki L Clifton, Ian M R Wright

Affiliations

  1. Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW, Australia (R.M.D., H.K.P., J.L.L., I.R.W.) Discipline of Paediatrics and Child Health, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia (R.M.D., J.L.L., I.R.W.) Graduate School of Medicine and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia (R.M.D., I.R.W.).
  2. Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW, Australia (R.M.D., H.K.P., J.L.L., I.R.W.) School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia (H.K.P.).
  3. Kaleidoscope Neonatal Intensive Care Unit, John Hunter Children's Hospital, Newcastle, NSW, Australia (A.L., K.W., I.R.W.).
  4. Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW, Australia (R.M.D., H.K.P., J.L.L., I.R.W.) Discipline of Paediatrics and Child Health, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia (R.M.D., J.L.L., I.R.W.).
  5. Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA, Australia (V.L.C.).
  6. Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW, Australia (R.M.D., H.K.P., J.L.L., I.R.W.) Discipline of Paediatrics and Child Health, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia (R.M.D., J.L.L., I.R.W.) Graduate School of Medicine and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia (R.M.D., I.R.W.) Kaleidoscope Neonatal Intensive Care Unit, John Hunter Children's Hospital, Newcastle, NSW, Australia (A.L., K.W., I.R.W.).

PMID: 25350751 PMCID: PMC4270232 DOI: 10.14814/phy2.12145

Abstract

Dysfunction of the transition from fetal to neonatal circulatory systems may be a major contributor to poor outcome following preterm birth. Evidence exists in the human for both a period of low flow between 5 and 11 h and a later period of increased flow, suggesting a hypoperfusion-reperfusion cycle over the first 24 h following birth. Little is known about the regulation of peripheral blood flow during this time. The aim of this study was to conduct a comparative study between the human and guinea pig to characterize peripheral microvascular behavior during circulatory transition. Very preterm (≤28 weeks GA), preterm (29-36 weeks GA), and term (≥37 weeks GA) human neonates underwent laser Doppler analysis of skin microvascular blood flow at 6 and 24 h from birth. Guinea pig neonates were delivered prematurely (62 day GA) or at term (68-71 day GA) and laser Doppler analysis of skin microvascular blood flow was assessed every 2 h from birth. In human preterm neonates, there is a period of high microvascular flow at 24 h after birth. No period of low flow was observed at 6 h. In preterm animals, microvascular flow increased after birth, reaching a peak at 10 h postnatal age. Blood flow then steadily decreased, returning to delivery levels by 24 h. Preterm birth was associated with higher baseline microvascular flow throughout the study period in both human and guinea pig neonates. The findings do not support a hypoperfusion-reperfusion cycle in the microcirculation during circulatory transition. The guinea pig model of preterm birth will allow further investigation of the mechanisms underlying microvascular function and dysfunction during the initial extrauterine period.

© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Keywords: Guinea pig; hypoperfusion–reperfusion; microvascular blood flow; preterm neonate

References

  1. J Pediatr. 2010 Feb;156(2):191-6 - PubMed
  2. Pediatr Res. 2012 Jul;72(1):86-9 - PubMed
  3. Acta Anat (Basel). 1953;19(4):353-65 - PubMed
  4. Lancet. 2003 May 24;361(9371):1789-91 - PubMed
  5. Pediatr Res. 1987 May;21(5):427-31 - PubMed
  6. Semin Fetal Neonatal Med. 2006 Jun;11(3):166-73 - PubMed
  7. Arch Dis Child Fetal Neonatal Ed. 1996 Mar;74(2):F88-94 - PubMed
  8. Pediatr Cardiol. 1997 Mar-Apr;18(2):112-7 - PubMed
  9. J Pharmacol Toxicol Methods. 2006 Jul-Aug;54(1):1-25 - PubMed
  10. Pediatr Res. 2008 Nov;64(5):567-71 - PubMed
  11. Early Hum Dev. 2014 Aug;90(8):409-12 - PubMed
  12. Pediatrics. 2012 Jan;129(1):124-31 - PubMed
  13. Biochem Pharmacol. 2002 Aug 1;64(3):425-31 - PubMed
  14. Arch Dis Child Fetal Neonatal Ed. 2013 May;98(3):F212-7 - PubMed
  15. J Clin Endocrinol Metab. 2002 Jun;87(6):2838-42 - PubMed
  16. Pediatr Res. 2007 Mar;61(3):335-40 - PubMed
  17. Pediatrics. 2012 Jul;130(1):e115-25 - PubMed
  18. J Matern Fetal Neonatal Med. 2011 Oct;24(10):1215-20 - PubMed
  19. Anaesth Intensive Care. 2009 Sep;37(5):733-9 - PubMed
  20. Pediatr Res. 2012 Jan;71(1):20-4 - PubMed
  21. Acta Paediatr. 2002;91(4):434-9 - PubMed
  22. Acta Paediatr. 2010 Jan;99(1):135-9 - PubMed
  23. Arch Dis Child Fetal Neonatal Ed. 2008 Jul;93(4):F271-4 - PubMed
  24. Early Hum Dev. 2006 Dec;82(12):803-10 - PubMed
  25. Reprod Sci. 2010 Aug;17(8):776-82 - PubMed
  26. Adv Neonatal Care. 2009 Apr;9(2):77-81 - PubMed
  27. Arch Dis Child Fetal Neonatal Ed. 2008 Sep;93(5):F368-71 - PubMed
  28. Lancet. 1999 Apr 24;353(9162):1404-7 - PubMed
  29. Arch Dis Child Fetal Neonatal Ed. 2000 May;82(3):F188-94 - PubMed
  30. Trends Neurosci. 2001 Feb;24(2):91-8 - PubMed
  31. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 1;303(7):R769-77 - PubMed
  32. Neonatology. 2011;100(2):162-8 - PubMed
  33. Pediatr Res. 2013 Aug;74(2):186-90 - PubMed
  34. Am J Respir Cell Mol Biol. 1996 Jul;15(1):9-19 - PubMed
  35. Arch Dis Child Fetal Neonatal Ed. 2002 Nov;87(3):F181-4 - PubMed
  36. Pediatrics. 2009 Jul;124(1):277-84 - PubMed
  37. J Appl Physiol (1985). 2008 Jul;105(1):370-2 - PubMed
  38. Pediatr Res. 2008 Apr;63(4):415-9 - PubMed

Publication Types